valproic acid-458 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the valproic acid-458 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
AFF1 AF4/FMR2 family, member 1
AHI1 Abelson helper integration site 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
AP3M2 adaptor-related protein complex 3, mu 2 subunit
APAF1 apoptotic peptidase activating factor 1
ARL4C ADP-ribosylation factor-like 4C
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASB13 ankyrin repeat and SOCS box containing 13
BEX4 brain expressed, X-linked 4
BIN1 bridging integrator 1
BTG3 BTG family, member 3
C6ORF62 chromosome 6 open reading frame 62
CDH3 cadherin 3, type 1, P-cadherin (placental)
CNTD2 cyclin N-terminal domain containing 2
COBL cordon-bleu WH2 repeat protein
COX5B cytochrome c oxidase subunit Vb
CPE carboxypeptidase E
CREB3L1 cAMP responsive element binding protein 3-like 1
CREBL2 cAMP responsive element binding protein-like 2
CSRP2 cysteine and glycine-rich protein 2
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DSTYK dual serine/threonine and tyrosine protein kinase
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFNB3 ephrin-B3
EMC9 ER membrane protein complex subunit 9
ENG endoglin
EXOC6B exocyst complex component 6B
FAM188A family with sequence similarity 188, member A
FYN FYN proto-oncogene, Src family tyrosine kinase
GANAB glucosidase, alpha; neutral AB
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPR161 G protein-coupled receptor 161
GSK3A glycogen synthase kinase 3 alpha
HLA-C major histocompatibility complex, class I, C
HMOX2 heme oxygenase 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
INPP5K inositol polyphosphate-5-phosphatase K
LRRC42 leucine rich repeat containing 42
MAPKBP1 mitogen-activated protein kinase binding protein 1
MAST3 microtubule associated serine/threonine kinase 3
METTL7A methyltransferase like 7A
MRPS12 mitochondrial ribosomal protein S12
NELL2 NEL-like 2 (chicken)
NKIRAS2 NFKB inhibitor interacting Ras-like 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PHF1 PHD finger protein 1
PIGV phosphatidylinositol glycan anchor biosynthesis, class V
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G16 phospholipase A2, group XVI
PMM1 phosphomannomutase 1
PUS3 pseudouridylate synthase 3
RAB29 RAB29, member RAS oncogene family
RPL13 ribosomal protein L13
RPL14 ribosomal protein L14
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
SCAMP1 secretory carrier membrane protein 1
SCD5 stearoyl-CoA desaturase 5
SERBP1 SERPINE1 mRNA binding protein 1
SGMS1 sphingomyelin synthase 1
SH3GL1 SH3-domain GRB2-like 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
STX2 syntaxin 2
STXBP5L syntaxin binding protein 5-like
SYNGR1 synaptogyrin 1
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBPL1 TBP-like 1
TMCO6 transmembrane and coiled-coil domains 6
TMEM161A transmembrane protein 161A
TPT1 tumor protein, translationally-controlled 1
TRADD TNFRSF1A-associated via death domain
TREX1 three prime repair exonuclease 1
TRPS1 trichorhinophalangeal syndrome I
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
ULK1 unc-51 like autophagy activating kinase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR19 WD repeat domain 19
ZEB1 zinc finger E-box binding homeobox 1
ZNF211 zinc finger protein 211
ZNF253 zinc finger protein 253
ZNF287 zinc finger protein 287

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADRA2B adrenoceptor alpha 2B
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANAPC10 anaphase promoting complex subunit 10
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2
BCAR3 breast cancer anti-estrogen resistance 3
CASC3 cancer susceptibility candidate 3
CCDC176 coiled-coil domain containing 176
CD82 CD82 molecule
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CTRB2 chymotrypsinogen B2
DCAF4 DDB1 and CUL4 associated factor 4
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELAVL4 ELAV like neuron-specific RNA binding protein 4
ERCC4 excision repair cross-complementation group 4
ERCC6L excision repair cross-complementation group 6-like
ERMP1 endoplasmic reticulum metallopeptidase 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1L ERO1-like (S. cerevisiae)
FAN1 FANCD2/FANCI-associated nuclease 1
FIP1L1 factor interacting with PAPOLA and CPSF1
FJX1 four jointed box 1 (Drosophila)
FST follistatin
FZD8 frizzled class receptor 8
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GALR3 galanin receptor 3
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GFOD1 glucose-fructose oxidoreductase domain containing 1
GPKOW G patch domain and KOW motifs
GRIP2 glutamate receptor interacting protein 2
GRWD1 glutamate-rich WD repeat containing 1
HAS2 hyaluronan synthase 2
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HMGA2 high mobility group AT-hook 2
INHBB inhibin, beta B
IP6K2 inositol hexakisphosphate kinase 2
KCTD15 potassium channel tetramerization domain containing 15
KEAP1 kelch-like ECH-associated protein 1
KLHL21 kelch-like family member 21
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LINC00339 long intergenic non-protein coding RNA 339
LOC100127972 uncharacterized LOC100127972
MAD2L1BP MAD2L1 binding protein
MARC1 mitochondrial amidoxime reducing component 1
MPV17 MpV17 mitochondrial inner membrane protein
MRPL35 mitochondrial ribosomal protein L35
NABP2 nucleic acid binding protein 2
NAT10 N-acetyltransferase 10 (GCN5-related)
NCS1 neuronal calcium sensor 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME6 NME/NM23 nucleoside diphosphate kinase 6
NR3C2 nuclear receptor subfamily 3, group C, member 2
OR2C1 olfactory receptor, family 2, subfamily C, member 1
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PAGR1 PAXIP1 associated glutamate-rich protein 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCNT pericentrin
PEX13 peroxisomal biogenesis factor 13
PF4 platelet factor 4
PHC1 polyhomeotic homolog 1 (Drosophila)
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLAU plasminogen activator, urokinase
PPCS phosphopantothenoylcysteine synthetase
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PUS1 pseudouridylate synthase 1
RABGGTA Rab geranylgeranyltransferase, alpha subunit
RABL6 RAB, member RAS oncogene family-like 6
RBM4B RNA binding motif protein 4B
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RIN2 Ras and Rab interactor 2
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SIRT6 sirtuin 6
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SNX5 sorting nexin 5
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like
SREBF1 sterol regulatory element binding transcription factor 1
SSUH2 ssu-2 homolog (C. elegans)
SUSD4 sushi domain containing 4
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMED1 transmembrane emp24 protein transport domain containing 1
TMEM184C transmembrane protein 184C
TMEM185B transmembrane protein 185B
TRIM58 tripartite motif containing 58
TTC27 tetratricopeptide repeat domain 27
TYK2 tyrosine kinase 2
U2AF1 U2 small nuclear RNA auxiliary factor 1
UPK2 uroplakin 2
YEATS2 YEATS domain containing 2
YPEL1 yippee-like 1 (Drosophila)
ZNF532 zinc finger protein 532