valproic acid-5237 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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200 genes differentially expressed following the valproic acid-5237 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APP amyloid beta (A4) precursor protein
BAX BCL2-associated X protein
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BMP7 bone morphogenetic protein 7
C19ORF66 chromosome 19 open reading frame 66
C22ORF46 chromosome 22 open reading frame 46
CCRL2 chemokine (C-C motif) receptor-like 2
CD1A CD1a molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CDON cell adhesion associated, oncogene regulated
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
COL1A1 collagen, type I, alpha 1
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DFNB31 deafness, autosomal recessive 31
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EFNB3 ephrin-B3
EGFL7 EGF-like-domain, multiple 7
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP10 FK506 binding protein 10, 65 kDa
FOXN3 forkhead box N3
FXR2 fragile X mental retardation, autosomal homolog 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAP43 growth associated protein 43
GATAD2A GATA zinc finger domain containing 2A
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GNRHR gonadotropin-releasing hormone receptor
GYG2 glycogenin 2
HIRA histone cell cycle regulator
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
IMPG2 interphotoreceptor matrix proteoglycan 2
ITM2C integral membrane protein 2C
KIF3C kinesin family member 3C
KLF13 Kruppel-like factor 13
KRT15 keratin 15, type I
KRT8 keratin 8, type II
LHX2 LIM homeobox 2
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARK4 MAP/microtubule affinity-regulating kinase 4
MAST3 microtubule associated serine/threonine kinase 3
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDFI MyoD family inhibitor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED25 mediator complex subunit 25
NCR2 natural cytotoxicity triggering receptor 2
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOL10 nucleolar protein 10
NOP16 NOP16 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
PBX2 pre-B-cell leukemia homeobox 2
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLAT plasminogen activator, tissue
PLCD1 phospholipase C, delta 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PORCN porcupine homolog (Drosophila)
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTGIS prostaglandin I2 (prostacyclin) synthase
PTRF polymerase I and transcript release factor
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAI2 retinoic acid induced 2
REST RE1-silencing transcription factor
RGS12 regulator of G-protein signaling 12
RIMS2 regulating synaptic membrane exocytosis 2
RIMS3 regulating synaptic membrane exocytosis 3
SAA3P serum amyloid A3 pseudogene
SARM1 sterile alpha and TIR motif containing 1
SDC3 syndecan 3
SH3BP2 SH3-domain binding protein 2
SLC35E2 solute carrier family 35, member E2
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SMG7 SMG7 nonsense mediated mRNA decay factor
SP100 SP100 nuclear antigen
SPAG4 sperm associated antigen 4
SPON2 spondin 2, extracellular matrix protein
ST20 suppressor of tumorigenicity 20
STK16 serine/threonine kinase 16
STK4 serine/threonine kinase 4
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCEAL2 transcription elongation factor A (SII)-like 2
TMC6 transmembrane channel-like 6
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TRH thyrotropin-releasing hormone
TSC22D2 TSC22 domain family, member 2
TUBA3C tubulin, alpha 3c
WSCD1 WSC domain containing 1
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF204P zinc finger protein 204, pseudogene
ZNF419 zinc finger protein 419
ZNF528 zinc finger protein 528
ZNF821 zinc finger protein 821
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AHR aryl hydrocarbon receptor
ALPK1 alpha-kinase 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANP32A-IT1 ANP32A intronic transcript 1
ARPIN actin-related protein 2/3 complex inhibitor
ARRB1 arrestin, beta 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CIDEC cell death-inducing DFFA-like effector c
CLDN15 claudin 15
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUZD1 CUB and zona pellucida-like domains 1
CXADR coxsackie virus and adenovirus receptor
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
ERCC4 excision repair cross-complementation group 4
EXO5 exonuclease 5
FBXO31 F-box protein 31
FRS2 fibroblast growth factor receptor substrate 2
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GDAP1 ganglioside induced differentiation associated protein 1
GID4 GID complex subunit 4
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPR27 G protein-coupled receptor 27
GSTTP1 glutathione S-transferase theta pseudogene 1
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H4F histone cluster 1, H4f
HIST2H2AA3 histone cluster 2, H2aa3
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA4 homeobox A4
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL22 interleukin 22
IPP intracisternal A particle-promoted polypeptide
LENEP lens epithelial protein
LIME1 Lck interacting transmembrane adaptor 1
LMAN1 lectin, mannose-binding, 1
LRRC37A3 leucine rich repeat containing 37, member A3
MAPKBP1 mitogen-activated protein kinase binding protein 1
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MMP3 matrix metallopeptidase 3
MOCS3 molybdenum cofactor synthesis 3
MVP major vault protein
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PADI1 peptidyl arginine deiminase, type I
PCDHA9 protocadherin alpha 9
PCDHB8 protocadherin beta 8
PDE8B phosphodiesterase 8B
PRODH proline dehydrogenase (oxidase) 1
QSER1 glutamine and serine rich 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RGS2 regulator of G-protein signaling 2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
ROM1 retinal outer segment membrane protein 1
S100A7 S100 calcium binding protein A7
SENP7 SUMO1/sentrin specific peptidase 7
SEPP1 selenoprotein P, plasma, 1
SKI SKI proto-oncogene
SLC22A14 solute carrier family 22, member 14
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SNAI2 snail family zinc finger 2
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPRYD7 SPRY domain containing 7
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STON1 stonin 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYTL2 synaptotagmin-like 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TEP1 telomerase-associated protein 1
TMEM212 transmembrane protein 212
TMEM53 transmembrane protein 53
TMPRSS3 transmembrane protease, serine 3
TRIM16 tripartite motif containing 16
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
UBQLN4 ubiquilin 4
UBXN8 UBX domain protein 8
VEZT vezatin, adherens junctions transmembrane protein
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
YAF2 YY1 associated factor 2
ZNF408 zinc finger protein 408
ZNF430 zinc finger protein 430
ZNF446 zinc finger protein 446
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721
ZNF747 zinc finger protein 747
ZNF770 zinc finger protein 770