valproic acid-5569 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the valproic acid-5569 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ACSL5 acyl-CoA synthetase long-chain family member 5
ACSL6 acyl-CoA synthetase long-chain family member 6
AFF2 AF4/FMR2 family, member 2
AMPD3 adenosine monophosphate deaminase 3
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARHGAP4 Rho GTPase activating protein 4
ATF6B activating transcription factor 6 beta
ATP10B ATPase, class V, type 10B
C5AR1 complement component 5a receptor 1
C8A complement component 8, alpha polypeptide
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCDC64 coiled-coil domain containing 64
CD247 CD247 molecule
CDC14A cell division cycle 14A
CYHR1 cysteine/histidine-rich 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DGAT1 diacylglycerol O-acyltransferase 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DRD1 dopamine receptor D1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FADS3 fatty acid desaturase 3
FAM182B family with sequence similarity 182, member B
FAM46C family with sequence similarity 46, member C
FGF18 fibroblast growth factor 18
FRS3 fibroblast growth factor receptor substrate 3
FST follistatin
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GAS1 growth arrest-specific 1
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GNAS GNAS complex locus
GPR176 G protein-coupled receptor 176
GSK3A glycogen synthase kinase 3 alpha
GZMK granzyme K (granzyme 3; tryptase II)
HIPK2 homeodomain interacting protein kinase 2
HIST1H2BN histone cluster 1, H2bn
HSF1 heat shock transcription factor 1
ICOSLG inducible T-cell co-stimulator ligand
IDI2-AS1 IDI2 antisense RNA 1
IGF2-AS IGF2 antisense RNA
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITM2C integral membrane protein 2C
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KHK ketohexokinase (fructokinase)
KIAA0319L KIAA0319-like
KLHL29 kelch-like family member 29
MAPK14 mitogen-activated protein kinase 14
MARK4 MAP/microtubule affinity-regulating kinase 4
METTL7A methyltransferase like 7A
MFGE8 milk fat globule-EGF factor 8 protein
MLANA melan-A
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NCKIPSD NCK interacting protein with SH3 domain
NID1 nidogen 1
NOP14-AS1 NOP14 antisense RNA 1
NRG2 neuregulin 2
OLFM1 olfactomedin 1
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OTUD7B OTU deubiquitinase 7B
PCDHGA3 protocadherin gamma subfamily A, 3
PCNX pecanex homolog (Drosophila)
PDPN podoplanin
PHF20L1 PHD finger protein 20-like 1
PIP prolactin-induced protein
PRB1 proline-rich protein BstNI subfamily 1
PRB3 proline-rich protein BstNI subfamily 3
PRM1 protamine 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REEP2 receptor accessory protein 2
RUNX1 runt-related transcription factor 1
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SERGEF secretion regulating guanine nucleotide exchange factor
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIRT5 sirtuin 5
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPTBN1 spectrin, beta, non-erythrocytic 1
STATH statherin
SYN2 synapsin II
TBC1D22B TBC1 domain family, member 22B
TG thyroglobulin
TIMP3 TIMP metallopeptidase inhibitor 3
TRIM29 tripartite motif containing 29
UNC13A unc-13 homolog A (C. elegans)
VPRBP Vpr (HIV-1) binding protein
WIPF1 WAS/WASL interacting protein family, member 1
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF37BP zinc finger protein 37B, pseudogene
ZNF440 zinc finger protein 440
ZNF500 zinc finger protein 500

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACBD4 acyl-CoA binding domain containing 4
ACYP2 acylphosphatase 2, muscle type
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ANKRD36 ankyrin repeat domain 36
ATP10D ATPase, class V, type 10D
AXIN1 axin 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B9D2 B9 protein domain 2
BAHCC1 BAH domain and coiled-coil containing 1
BTBD3 BTB (POZ) domain containing 3
C11ORF30 chromosome 11 open reading frame 30
C1QTNF3 C1q and tumor necrosis factor related protein 3
C2ORF54 chromosome 2 open reading frame 54
C8ORF60 chromosome 8 open reading frame 60
CA5BP1 carbonic anhydrase VB pseudogene 1
CCDC132 coiled-coil domain containing 132
CDK20 cyclin-dependent kinase 20
CLEC16A C-type lectin domain family 16, member A
CRY2 cryptochrome circadian clock 2
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DNA2 DNA replication helicase/nuclease 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOCK4 dedicator of cytokinesis 4
FAAH fatty acid amide hydrolase
FAM214B family with sequence similarity 214, member B
FBXO31 F-box protein 31
FLJ11710 uncharacterized protein FLJ11710
GLS2 glutaminase 2 (liver, mitochondrial)
GPATCH2L G patch domain containing 2-like
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HCFC2 host cell factor C2
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2AJ histone cluster 1, H2aj
HIST1H2AL histone cluster 1, H2al
HIST1H3B histone cluster 1, H3b
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOXB2 homeobox B2
IPO8 importin 8
IQCC IQ motif containing C
IRS2 insulin receptor substrate 2
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KLHL21 kelch-like family member 21
KRT15 keratin 15, type I
LIME1 Lck interacting transmembrane adaptor 1
MANBA mannosidase, beta A, lysosomal
MB myoglobin
MECR mitochondrial trans-2-enoyl-CoA reductase
MFAP2 microfibrillar-associated protein 2
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MOSPD3 motile sperm domain containing 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEK11 NIMA-related kinase 11
NHEJ1 nonhomologous end-joining factor 1
NTF3 neurotrophin 3
OSGIN1 oxidative stress induced growth inhibitor 1
OSMR oncostatin M receptor
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PLK3 polo-like kinase 3
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
PPT2 palmitoyl-protein thioesterase 2
PROS1 protein S (alpha)
PTPRS protein tyrosine phosphatase, receptor type, S
RAB33B RAB33B, member RAS oncogene family
RASAL1 RAS protein activator like 1 (GAP1 like)
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RFPL3 ret finger protein-like 3
ROM1 retinal outer segment membrane protein 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
STARD5 StAR-related lipid transfer (START) domain containing 5
STK25 serine/threonine kinase 25
TBX19 T-box 19
TMEM120B transmembrane protein 120B
TMEM132A transmembrane protein 132A
TMEM209 transmembrane protein 209
TMEM39B transmembrane protein 39B
TPK1 thiamin pyrophosphokinase 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TUBA3C tubulin, alpha 3c
VIM vimentin
VPS9D1 VPS9 domain containing 1
WLS wntless Wnt ligand secretion mediator
ZC3H3 zinc finger CCCH-type containing 3
ZNF747 zinc finger protein 747
ZNF767P zinc finger family member 767, pseudogene
ZNF778 zinc finger protein 778
ZNF862 zinc finger protein 862