valproic acid-5582 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the valproic acid-5582 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADRB1 adrenoceptor beta 1
ALDOB aldolase B, fructose-bisphosphate
ASCL1 achaete-scute family bHLH transcription factor 1
ATP10B ATPase, class V, type 10B
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BEND5 BEN domain containing 5
BST2 bone marrow stromal cell antigen 2
C3AR1 complement component 3a receptor 1
CA1 carbonic anhydrase I
CADM3 cell adhesion molecule 3
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CD226 CD226 molecule
CD4 CD4 molecule
CD7 CD7 molecule
CDC42 cell division cycle 42
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN2A cyclin-dependent kinase inhibitor 2A
CENPO centromere protein O
CLCA1 chloride channel accessory 1
CLEC4E C-type lectin domain family 4, member E
COL11A2 collagen, type XI, alpha 2
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
CYHR1 cysteine/histidine-rich 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DGCR8 DGCR8 microprocessor complex subunit
DPF1 D4, zinc and double PHD fingers family 1
DTX2 deltex 2, E3 ubiquitin ligase
EFR3B EFR3 homolog B (S. cerevisiae)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ELL elongation factor RNA polymerase II
FBXO21 F-box protein 21
FCAR Fc fragment of IgA receptor
FN1 fibronectin 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GGT1 gamma-glutamyltransferase 1
GJA9 gap junction protein, alpha 9, 59kDa
HEXIM1 hexamethylene bis-acetamide inducible 1
HHAT hedgehog acyltransferase
HNF4A hepatocyte nuclear factor 4, alpha
IFFO1 intermediate filament family orphan 1
IFI6 interferon, alpha-inducible protein 6
IFNG interferon, gamma
IGSF6 immunoglobulin superfamily, member 6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IZUMO4 IZUMO family member 4
KANK1 KN motif and ankyrin repeat domains 1
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KRT14 keratin 14, type I
KRT31 keratin 31, type I
KRTAP2-4 keratin associated protein 2-4
LEFTY2 left-right determination factor 2
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LTBP4 latent transforming growth factor beta binding protein 4
MAPK11 mitogen-activated protein kinase 11
MBNL2 muscleblind-like splicing regulator 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFSD7 major facilitator superfamily domain containing 7
MIP major intrinsic protein of lens fiber
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MPPE1 metallophosphoesterase 1
MTSS1L metastasis suppressor 1-like
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NOVA1 neuro-oncological ventral antigen 1
OMG oligodendrocyte myelin glycoprotein
PCDH9 protocadherin 9
PCDHB11 protocadherin beta 11
PCDHB12 protocadherin beta 12
PDCD6 programmed cell death 6
PEG3 paternally expressed 3
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB2 phospholipase C, beta 2
PMFBP1 polyamine modulated factor 1 binding protein 1
PPARD peroxisome proliferator-activated receptor delta
PRB1 proline-rich protein BstNI subfamily 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRY PTPN13-like, Y-linked
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
R3HDM1 R3H domain containing 1
RAPSN receptor-associated protein of the synapse
RUSC2 RUN and SH3 domain containing 2
SFTPD surfactant protein D
SHOX2 short stature homeobox 2
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SPRR2B small proline-rich protein 2B
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRSF5 serine/arginine-rich splicing factor 5
TBXA2R thromboxane A2 receptor
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
WDR78 WD repeat domain 78
ZFP64 ZFP64 zinc finger protein
ZNF235 zinc finger protein 235
ZNF384 zinc finger protein 384

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACSF2 acyl-CoA synthetase family member 2
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BFSP1 beaded filament structural protein 1, filensin
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDK3 cyclin-dependent kinase 3
CIC capicua transcriptional repressor
CLEC16A C-type lectin domain family 16, member A
COPZ2 coatomer protein complex, subunit zeta 2
CRABP1 cellular retinoic acid binding protein 1
CRY2 cryptochrome circadian clock 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
CST6 cystatin E/M
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTSK cathepsin K
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DNM1 dynamin 1
DOC2A double C2-like domains, alpha
DUSP8 dual specificity phosphatase 8
EXD3 exonuclease 3'-5' domain containing 3
FBXL6 F-box and leucine-rich repeat protein 6
FBXO22 F-box protein 22
GCHFR GTP cyclohydrolase I feedback regulator
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GID4 GID complex subunit 4
GLI3 GLI family zinc finger 3
GPR87 G protein-coupled receptor 87
HDAC5 histone deacetylase 5
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HMHA1 histocompatibility (minor) HA-1
HOXA4 homeobox A4
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
ISYNA1 inositol-3-phosphate synthase 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KDM5C lysine (K)-specific demethylase 5C
KIAA0319L KIAA0319-like
KRT15 keratin 15, type I
LAMP3 lysosomal-associated membrane protein 3
LHX6 LIM homeobox 6
LIN37 lin-37 DREAM MuvB core complex component
LIN7A lin-7 homolog A (C. elegans)
LINC00115 long intergenic non-protein coding RNA 115
LOC100286895 cell division cycle 27 homolog pseudogene
LOC100287590 uncharacterized LOC100287590
MDM4 MDM4, p53 regulator
MFSD11 major facilitator superfamily domain containing 11
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MVD mevalonate (diphospho) decarboxylase
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NBEAL2 neurobeachin-like 2
NECAB3 N-terminal EF-hand calcium binding protein 3
NEK11 NIMA-related kinase 11
NPFFR1 neuropeptide FF receptor 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NTF3 neurotrophin 3
OSGIN1 oxidative stress induced growth inhibitor 1
PADI1 peptidyl arginine deiminase, type I
PCDHA6 protocadherin alpha 6
PCDHB8 protocadherin beta 8
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGBD5 piggyBac transposable element derived 5
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PODXL2 podocalyxin-like 2
PPAP2C phosphatidic acid phosphatase type 2C
PRKX protein kinase, X-linked
QTRT1 queuine tRNA-ribosyltransferase 1
RFTN1 raftlin, lipid raft linker 1
RIN2 Ras and Rab interactor 2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SIRT2 sirtuin 2
SLC12A8 solute carrier family 12, member 8
SLC35F5 solute carrier family 35, member F5
SLIT2 slit homolog 2 (Drosophila)
SLPI secretory leukocyte peptidase inhibitor
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SSNA1 Sjogren syndrome nuclear autoantigen 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TCTN2 tectonic family member 2
TMEM104 transmembrane protein 104
TMEM242 transmembrane protein 242
TMEM53 transmembrane protein 53
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TOM1 target of myb1 (chicken)
TRAIP TRAF interacting protein
TRDMT1 tRNA aspartic acid methyltransferase 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTBK2 tau tubulin kinase 2
VAX2 ventral anterior homeobox 2
VGF VGF nerve growth factor inducible
XK X-linked Kx blood group
ZBED1 zinc finger, BED-type containing 1
ZNF442 zinc finger protein 442
ZNF446 zinc finger protein 446
ZNF580 zinc finger protein 580
ZNF768 zinc finger protein 768