valproic acid-5600 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the valproic acid-5600 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADAM17 ADAM metallopeptidase domain 17
AKT2 v-akt murine thymoma viral oncogene homolog 2
APAF1 apoptotic peptidase activating factor 1
ARMCX2 armadillo repeat containing, X-linked 2
ATAT1 alpha tubulin acetyltransferase 1
ATP10B ATPase, class V, type 10B
BBX bobby sox homolog (Drosophila)
BCORL1 BCL6 corepressor-like 1
BEX4 brain expressed, X-linked 4
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C19ORF66 chromosome 19 open reading frame 66
C2ORF27A chromosome 2 open reading frame 27A
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CD36 CD36 molecule (thrombospondin receptor)
CD70 CD70 molecule
CDK18 cyclin-dependent kinase 18
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFAP70 cilia and flagella associated protein 70
CHST10 carbohydrate sulfotransferase 10
CPQ carboxypeptidase Q
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
CTNS cystinosin, lysosomal cystine transporter
CYLD cylindromatosis (turban tumor syndrome)
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGCR8 DGCR8 microprocessor complex subunit
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DMXL2 Dmx-like 2
DPY19L1P1 DPY19L1 pseudogene 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFNB3 ephrin-B3
EVA1B eva-1 homolog B (C. elegans)
EXOC6B exocyst complex component 6B
FADS3 fatty acid desaturase 3
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FYN FYN proto-oncogene, Src family tyrosine kinase
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GFI1 growth factor independent 1 transcription repressor
GGT1 gamma-glutamyltransferase 1
GLRX glutaredoxin (thioltransferase)
GRK5 G protein-coupled receptor kinase 5
HDAC7 histone deacetylase 7
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1R insulin-like growth factor 1 receptor
ING2 inhibitor of growth family, member 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0040 KIAA0040
KIAA0895 KIAA0895
KIAA1109 KIAA1109
LAT2 linker for activation of T cells family, member 2
LIMCH1 LIM and calponin homology domains 1
LINC00341 long intergenic non-protein coding RNA 341
MAPT microtubule-associated protein tau
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MTSS1 metastasis suppressor 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NDRG2 NDRG family member 2
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NPAS2 neuronal PAS domain protein 2
NR6A1 nuclear receptor subfamily 6, group A, member 1
ORAI2 ORAI calcium release-activated calcium modulator 2
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
RAB29 RAB29, member RAS oncogene family
RAI2 retinoic acid induced 2
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
SALL2 spalt-like transcription factor 2
SC5D sterol-C5-desaturase
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SIX1 SIX homeobox 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SOGA1 suppressor of glucose, autophagy associated 1
SRCAP Snf2-related CREBBP activator protein
TADA3 transcriptional adaptor 3
TBC1D2 TBC1 domain family, member 2
TBXA2R thromboxane A2 receptor
TMC6 transmembrane channel-like 6
TMOD2 tropomodulin 2 (neuronal)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNIK TRAF2 and NCK interacting kinase
TRIM2 tripartite motif containing 2
TTC33 tetratricopeptide repeat domain 33
USP29 ubiquitin specific peptidase 29
VWA5A von Willebrand factor A domain containing 5A
ZBTB18 zinc finger and BTB domain containing 18
ZC3H7B zinc finger CCCH-type containing 7B
ZNF37BP zinc finger protein 37B, pseudogene
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADIRF adipogenesis regulatory factor
APLP1 amyloid beta (A4) precursor-like protein 1
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
B9D2 B9 protein domain 2
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C10ORF2 chromosome 10 open reading frame 2
C14ORF79 chromosome 14 open reading frame 79
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CABP2 calcium binding protein 2
CCDC132 coiled-coil domain containing 132
CCRL2 chemokine (C-C motif) receptor-like 2
CEP112 centrosomal protein 112kDa
CFAP45 cilia and flagella associated protein 45
CLDN15 claudin 15
CNPY4 canopy FGF signaling regulator 4
CXCR2 chemokine (C-X-C motif) receptor 2
DENND5B DENN/MADD domain containing 5B
ECH1 enoyl CoA hydratase 1, peroxisomal
ECHDC1 ethylmalonyl-CoA decarboxylase 1
EMID1 EMI domain containing 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERN1 endoplasmic reticulum to nucleus signaling 1
ETNK2 ethanolamine kinase 2
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FGF6 fibroblast growth factor 6
FHIT fragile histidine triad
FKBP10 FK506 binding protein 10, 65 kDa
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GATA4 GATA binding protein 4
GEMIN8 gem (nuclear organelle) associated protein 8
GLRA1 glycine receptor, alpha 1
GRPR gastrin-releasing peptide receptor
GSTM5 glutathione S-transferase mu 5
GSTP1 glutathione S-transferase pi 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2BM histone cluster 1, H2bm
HIST1H3I histone cluster 1, H3i
HOXA4 homeobox A4
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIAA0319L KIAA0319-like
KRT15 keratin 15, type I
KRT24 keratin 24, type I
LRRC8E leucine rich repeat containing 8 family, member E
LRRTM2 leucine rich repeat transmembrane neuronal 2
LY6D lymphocyte antigen 6 complex, locus D
MDM4 MDM4, p53 regulator
NTF3 neurotrophin 3
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OVGP1 oviductal glycoprotein 1, 120kDa
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PARP3 poly (ADP-ribose) polymerase family, member 3
PCBP4 poly(rC) binding protein 4
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PLA2G3 phospholipase A2, group III
PORCN porcupine homolog (Drosophila)
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRF1 perforin 1 (pore forming protein)
PYCRL pyrroline-5-carboxylate reductase-like
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REM1 RAS (RAD and GEM)-like GTP-binding 1
RPS14P3 ribosomal protein S14 pseudogene 3
RPS21 ribosomal protein S21
RPS4Y1 ribosomal protein S4, Y-linked 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SAYSD1 SAYSVFN motif domain containing 1
SECTM1 secreted and transmembrane 1
SLC22A14 solute carrier family 22, member 14
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SLMO1 slowmo homolog 1 (Drosophila)
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SREBF1 sterol regulatory element binding transcription factor 1
SSTR4 somatostatin receptor 4
STIM1 stromal interaction molecule 1
STK16 serine/threonine kinase 16
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TARP TCR gamma alternate reading frame protein
TAS2R10 taste receptor, type 2, member 10
TGFBR1 transforming growth factor, beta receptor 1
TMLHE trimethyllysine hydroxylase, epsilon
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRAIP TRAF interacting protein
UPK2 uroplakin 2
USP27X ubiquitin specific peptidase 27, X-linked
XYLT2 xylosyltransferase II
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZFHX4 zinc finger homeobox 4
ZNF408 zinc finger protein 408
ZNF506 zinc finger protein 506
ZNF551 zinc finger protein 551
ZNF747 zinc finger protein 747
ZNHIT2 zinc finger, HIT-type containing 2
ZXDB zinc finger, X-linked, duplicated B