valproic acid-6181 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the valproic acid-6181 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ACTN2 actinin, alpha 2
ACVR1B activin A receptor, type IB
ADGRL3 adhesion G protein-coupled receptor L3
AIM1L absent in melanoma 1-like
ANGPT4 angiopoietin 4
ASTN1 astrotactin 1
BCAS1 breast carcinoma amplified sequence 1
BMP7 bone morphogenetic protein 7
BRS3 bombesin-like receptor 3
C2ORF27A chromosome 2 open reading frame 27A
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCDC57 coiled-coil domain containing 57
CCL27 chemokine (C-C motif) ligand 27
CD59 CD59 molecule, complement regulatory protein
CD6 CD6 molecule
CDC25C cell division cycle 25C
CELF3 CUGBP, Elav-like family member 3
CFHR4 complement factor H-related 4
CGA glycoprotein hormones, alpha polypeptide
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
COL1A1 collagen, type I, alpha 1
COL8A1 collagen, type VIII, alpha 1
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
EFNA3 ephrin-A3
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EPS8L1 EPS8-like 1
ESR1 estrogen receptor 1
ETNK2 ethanolamine kinase 2
EXPH5 exophilin 5
FBXL18 F-box and leucine-rich repeat protein 18
FGFR3 fibroblast growth factor receptor 3
FMO5 flavin containing monooxygenase 5
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GJA8 gap junction protein, alpha 8, 50kDa
GPR107 G protein-coupled receptor 107
GPX2 glutathione peroxidase 2
GRIK2 glutamate receptor, ionotropic, kainate 2
GSTT1 glutathione S-transferase theta 1
GTDC1 glycosyltransferase-like domain containing 1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HAB1 B1 for mucin
HIST1H2BN histone cluster 1, H2bn
HOXA10 homeobox A10
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IL23A interleukin 23, alpha subunit p19
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDM4B lysine (K)-specific demethylase 4B
KRT81 keratin 81, type II
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIMD1 LIM domains containing 1
LOXL3 lysyl oxidase-like 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MPDZ multiple PDZ domain protein
NCAN neurocan
NDNF neuron-derived neurotrophic factor
NGB neuroglobin
NKX3-1 NK3 homeobox 1
NOX1 NADPH oxidase 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OXCT2 3-oxoacid CoA transferase 2
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PALLD palladin, cytoskeletal associated protein
PAPPA2 pappalysin 2
PCLO piccolo presynaptic cytomatrix protein
PDCD6 programmed cell death 6
PEX11A peroxisomal biogenesis factor 11 alpha
PHC3 polyhomeotic homolog 3 (Drosophila)
PIWIL1 piwi-like RNA-mediated gene silencing 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PROX1 prospero homeobox 1
RAB3D RAB3D, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBM19 RNA binding motif protein 19
RORA RAR-related orphan receptor A
RPS4Y1 ribosomal protein S4, Y-linked 1
RTEL1 regulator of telomere elongation helicase 1
SDC1 syndecan 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC16A4 solute carrier family 16, member 4
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
TAGLN3 transgelin 3
TCF20 transcription factor 20 (AR1)
TP63 tumor protein p63
TUBG2 tubulin, gamma 2
VASH2 vasohibin 2

decreased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
ACP5 acid phosphatase 5, tartrate resistant
ACP6 acid phosphatase 6, lysophosphatidic
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALS2CL ALS2 C-terminal like
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BTBD18 BTB (POZ) domain containing 18
BTD biotinidase
C11ORF68 chromosome 11 open reading frame 68
C16ORF59 chromosome 16 open reading frame 59
C2CD2 C2 calcium-dependent domain containing 2
CCL4 chemokine (C-C motif) ligand 4
CD320 CD320 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHMP7 charged multivesicular body protein 7
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCN5 chloride channel, voltage-sensitive 5
CTSO cathepsin O
CTSV cathepsin V
DNMBP dynamin binding protein
DYM dymeclin
ECH1 enoyl CoA hydratase 1, peroxisomal
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFTUD1 elongation factor Tu GTP binding domain containing 1
EXD3 exonuclease 3'-5' domain containing 3
FAM222B family with sequence similarity 222, member B
FRMD1 FERM domain containing 1
FURIN furin (paired basic amino acid cleaving enzyme)
HIST1H2BH histone cluster 1, H2bh
IFI44L interferon-induced protein 44-like
INO80D INO80 complex subunit D
IRX5 iroquois homeobox 5
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM7A lysine (K)-specific demethylase 7A
KIAA0319L KIAA0319-like
LAMB3 laminin, beta 3
LRRK1 leucine-rich repeat kinase 1
MCOLN1 mucolipin 1
MOCOS molybdenum cofactor sulfurase
MRAS muscle RAS oncogene homolog
MTMR12 myotubularin related protein 12
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MUM1 melanoma associated antigen (mutated) 1
MYBBP1A MYB binding protein (P160) 1a
NARFL nuclear prelamin A recognition factor-like
NDE1 nudE neurodevelopment protein 1
NPFFR1 neuropeptide FF receptor 1
NRBP1 nuclear receptor binding protein 1
PDE12 phosphodiesterase 12
PHC1 polyhomeotic homolog 1 (Drosophila)
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PQLC2 PQ loop repeat containing 2
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PYGB phosphorylase, glycogen; brain
RAB33A RAB33A, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RETN resistin
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RPAP1 RNA polymerase II associated protein 1
RPP25 ribonuclease P/MRP 25kDa subunit
RWDD2A RWD domain containing 2A
SETD1A SET domain containing 1A
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SPATA20 spermatogenesis associated 20
STX17 syntaxin 17
SUSD6 sushi domain containing 6
TERT telomerase reverse transcriptase
TGFBR3 transforming growth factor, beta receptor III
THBS4 thrombospondin 4
THRAP3 thyroid hormone receptor associated protein 3
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM209 transmembrane protein 209
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNNT1 troponin T type 1 (skeletal, slow)
TOR4A torsin family 4, member A
TRAF1 TNF receptor-associated factor 1
TRIM66 tripartite motif containing 66
TTPAL tocopherol (alpha) transfer protein-like
TWSG1 twisted gastrulation BMP signaling modulator 1
USB1 U6 snRNA biogenesis 1
WDR62 WD repeat domain 62
XAB2 XPA binding protein 2
ZNF408 zinc finger protein 408
ZNF428 zinc finger protein 428
ZNF696 zinc finger protein 696
ZNF701 zinc finger protein 701
ZNF76 zinc finger protein 76
ZNF767P zinc finger family member 767, pseudogene