vancomycin Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
Description A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile. (Chemical Entities of Biological Interest Ontology, CHEBI_28001)
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Genes

13 genes differentially expressed following the vancomycin small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP10 caspase 10, apoptosis-related cysteine peptidase 5.36169
ZMYM2 zinc finger, MYM-type 2 4.55923
UBQLN2 ubiquilin 2 3.93612
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 3.61486
RRAD Ras-related associated with diabetes 3.3319
TATDN2 TatD DNase domain containing 2 3.21394
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) 3.05972
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 3.00168

decreased expression

Symbol Name Standardized Value
TOMM34 translocase of outer mitochondrial membrane 34 -3.84434
CERS6 ceramide synthase 6 -3.40268
PIGT phosphatidylinositol glycan anchor biosynthesis, class T -3.26817
PTPRO protein tyrosine phosphatase, receptor type, O -3.26016
REPS2 RALBP1 associated Eps domain containing 2 -3.20538