varicose veins Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin. (Human Disease Ontology, DOID_799)
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Genes

240 genes co-occuring with the disease varicose veins in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
EVL Enah/Vasp-like 2.09383
F2 coagulation factor II (thrombin) 1.64307
SST somatostatin 1.62425
ALB albumin 1.5194
RAB3D RAB3D, member RAS oncogene family 1.31668
PARVA parvin, alpha 1.27693
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.20266
F5 coagulation factor V (proaccelerin, labile factor) 1.11225
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.979689
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.977165
ACR acrosin 0.968341
HSPA2 heat shock 70kDa protein 2 0.95369
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.947435
FOXC2 forkhead box C2 0.939119
CCIN calicin 0.907731
ALPPL2 alkaline phosphatase, placental-like 2 0.888848
ALPP alkaline phosphatase, placental 0.888438
ALPL alkaline phosphatase, liver/bone/kidney 0.888029
MMP2 matrix metallopeptidase 2 0.883521
GLTP glycolipid transfer protein 0.875738
AFP alpha-fetoprotein 0.840115
SHBG sex hormone-binding globulin 0.827409
PROS1 protein S (alpha) 0.782707
PLG plasminogen 0.782298
CDC26 cell division cycle 26 0.781069
MMP9 matrix metallopeptidase 9 0.776159
F8 coagulation factor VIII, procoagulant component 0.77207
FBL fibrillarin 0.753713
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.72612
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.725716
SEMG2 semenogelin II 0.711587
SOD2 superoxide dismutase 2, mitochondrial 0.703938
FBLL1 fibrillarin-like 1 0.694702
CIRBP cold inducible RNA binding protein 0.689092
JMJD6 jumonji domain containing 6 0.687091
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.682693
PRL prolactin 0.65565
TIMP1 TIMP metallopeptidase inhibitor 1 0.646559
DRG2 developmentally regulated GTP binding protein 2 0.640645
HSFY1 heat shock transcription factor, Y-linked 1 0.617486
HSFY2 heat shock transcription factor, Y linked 2 0.617486
ANAPC4 anaphase promoting complex subunit 4 0.608885
MMP1 matrix metallopeptidase 1 0.60303
PRM2 protamine 2 0.597961
HYLS1 hydrolethalus syndrome 1 0.592895
DNTT DNA nucleotidylexotransferase 0.579272
COL3A1 collagen, type III, alpha 1 0.574994
VCL vinculin 0.564112
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.563723
BAX BCL2-associated X protein 0.562946
CYTIP cytohesin 1 interacting protein 0.559839
GPX5 glutathione peroxidase 5 0.554791
GPX4 glutathione peroxidase 4 0.551686
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 0.548195
MMP3 matrix metallopeptidase 3 0.540442
GPX1 glutathione peroxidase 1 0.535796
MTA1 metastasis associated 1 0.517649
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit 0.510728
BCHE butyrylcholinesterase 0.493503
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.493122
ARL2BP ADP-ribosylation factor-like 2 binding protein 0.485505
LDHC lactate dehydrogenase C 0.485505
VARS valyl-tRNA synthetase 0.483985
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.482464
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.482084
VILL villin-like 0.47374
G6PC3 glucose 6 phosphatase, catalytic, 3 0.469197
CDK5RAP3 CDK5 regulatory subunit associated protein 3 0.462394
RGS3 regulator of G-protein signaling 3 0.460506
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.454093
MLN motilin 0.452962
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 0.449571
AGGF1 angiogenic factor with G patch and FHA domains 1 0.447311
NOS3 nitric oxide synthase 3 (endothelial cell) 0.441666
ACPP acid phosphatase, prostate 0.440914
MT1M metallothionein 1M 0.438658
ACPT acid phosphatase, testicular 0.433772
F3 coagulation factor III (thromboplastin, tissue factor) 0.433772
SEPT2 septin 2 0.432646
LOXL1 lysyl oxidase-like 1 0.430393
PPT1 palmitoyl-protein thioesterase 1 0.42814
CDC16 cell division cycle 16 0.42664
SCG5 secretogranin V 0.42364
SEMG1 semenogelin I 0.409787
FAT3 FAT atypical cadherin 3 0.409787
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.407919
REN renin 0.403064
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.401945
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 0.401572
FN1 fibronectin 1 0.401572
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 0.399334
IGLL5 immunoglobulin lambda-like polypeptide 5 0.397843
PLAT plasminogen activator, tissue 0.394491
TNP1 transition protein 1 (during histone to protamine replacement) 0.388909
VWF von Willebrand factor 0.388166
TIMP2 TIMP metallopeptidase inhibitor 2 0.387794
MYOCD myocardin 0.382223
TUBE1 tubulin, epsilon 1 0.374809
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.371477
RLN2 relaxin 2 0.368888
CAT catalase 0.352291
GSTM1 glutathione S-transferase mu 1 0.351923
TAC3 tachykinin 3 0.350084
RND1 Rho family GTPase 1 0.349349
CATSPER1 cation channel, sperm associated 1 0.347879
APOLD1 apolipoprotein L domain containing 1 0.346777
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.344941
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.331025
EDN1 endothelin 1 0.328469
MAN2C1 mannosidase, alpha, class 2C, member 1 0.326281
SELE selectin E 0.323365
AMH anti-Mullerian hormone 0.321909
PCM1 pericentriolar material 1 0.320817
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.318999
FBXO44 F-box protein 44 0.315729
POU2F1 POU class 2 homeobox 1 0.313915
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.313552
PGRMC1 progesterone receptor membrane component 1 0.313189
SYNM synemin, intermediate filament protein 0.312827
BORA bora, aurora kinase A activator 0.310652
HSF2 heat shock transcription factor 2 0.307033
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 0.304864
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.302337
POMP proteasome maturation protein 0.296931
OR10K1 olfactory receptor, family 10, subfamily K, member 1 0.290821
KRTAP1-3 keratin associated protein 1-3 0.287235
KRTAP1-1 keratin associated protein 1-1 0.287235
RXFP1 relaxin/insulin-like family peptide receptor 1 0.287235
UNK unkempt family zinc finger 0.283655
STAR steroidogenic acute regulatory protein 0.280439
PER1 period circadian clock 1 0.278297
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.27794
CD79A CD79a molecule, immunoglobulin-associated alpha 0.277227
GANC glucosidase, alpha; neutral C 0.267622
WRNIP1 Werner helicase interacting protein 1 0.267267
SUCLG1 succinate-CoA ligase, alpha subunit 0.267267
CD68 CD68 molecule 0.267267
TF transferrin 0.265849
NOS2 nitric oxide synthase 2, inducible 0.264785
GLG1 golgi glycoprotein 1 0.263722
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.260538
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.260538
MMP13 matrix metallopeptidase 13 0.257711
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.251718
MMP7 matrix metallopeptidase 7 0.246098
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.243645
RXFP2 relaxin/insulin-like family peptide receptor 2 0.240148
F13B coagulation factor XIII, B polypeptide 0.23945
HBA1 hemoglobin, alpha 1 0.239101
FBN1 fibrillin 1 0.238752
TCEA1 transcription elongation factor A (SII), 1 0.23666
TPM4 tropomyosin 4 0.236312
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 0.23353
BIN2 bridging integrator 2 0.230755
GSTTP1 glutathione S-transferase theta pseudogene 1 0.229716
GSTT1 glutathione S-transferase theta 1 0.22937
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.229024
VANGL2 VANGL planar cell polarity protein 2 0.226607
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 0.224196
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.219398
HBA2 hemoglobin, alpha 2 0.219057
VANGL1 VANGL planar cell polarity protein 1 0.218374
AMHR2 anti-Mullerian hormone receptor, type II 0.216672
GPR148 G protein-coupled receptor 148 0.214297
AQP9 aquaporin 9 0.214297
CCDC27 coiled-coil domain containing 27 0.211597
PCNA proliferating cell nuclear antigen 0.211261
CMA1 chymase 1, mast cell 0.210925
CCM2 cerebral cavernous malformation 2 0.209248
MT-ATP8 ATP synthase F0 subunit 8 0.205585
FSHB follicle stimulating hormone, beta polypeptide 0.205585
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.204923
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.203275
PTS 6-pyruvoyltetrahydropterin synthase 0.202618
TWIST2 twist family bHLH transcription factor 2 0.202618
PTGES2 prostaglandin E synthase 2 0.201308
INS insulin 0.198709
TIMP3 TIMP metallopeptidase inhibitor 3 0.198386
KNG1 kininogen 1 0.198064
IL6 interleukin 6 0.197099
XPR1 xenotropic and polytropic retrovirus receptor 1 0.194548
PRM1 protamine 1 0.191719
AR androgen receptor 0.187719
LTBP3 latent transforming growth factor beta binding protein 3 0.183835
GCG glucagon 0.183541
COL14A1 collagen, type XIV, alpha 1 0.181222
VCAM1 vascular cell adhesion molecule 1 0.179802
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.178126
ALYREF Aly/REF export factor 0.177029
PATE1 prostate and testis expressed 1 0.173057
ICAM1 intercellular adhesion molecule 1 0.172038
BLVRA biliverdin reductase A 0.170544
ZNF85 zinc finger protein 85 0.166768
POMC proopiomelanocortin 0.166768
TP53 tumor protein p53 0.165874
DAZ1 deleted in azoospermia 1 0.162707
DAXX death-domain associated protein 0.162306
RNH1 ribonuclease/angiogenin inhibitor 1 0.162109
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 0.160761
LTBP2 latent transforming growth factor beta binding protein 2 0.160203
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.158951
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.147236
C5ORF38 chromosome 5 open reading frame 38 0.147114
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 0.145582
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.144716
LHB luteinizing hormone beta polypeptide 0.143136
DAZ2 deleted in azoospermia 2 0.142967
ACP1 acid phosphatase 1, soluble 0.142733
CLNK cytokine-dependent hematopoietic cell linker 0.142174
GSTA3 glutathione S-transferase alpha 3 0.141697
GSTA2 glutathione S-transferase alpha 2 0.141664
GSTA4 glutathione S-transferase alpha 4 0.14164
GSTA1 glutathione S-transferase alpha 1 0.141515
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.141455
HSPA1B heat shock 70kDa protein 1B 0.14136
PROK2 prokineticin 2 0.141079
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.14106
ANXA5 annexin A5 0.140563
GP2 glycoprotein 2 (zymogen granule membrane) 0.140159
PGC progastricsin (pepsinogen C) 0.140009
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.139932
INSL3 insulin-like 3 (Leydig cell) 0.139903
ARRB2 arrestin, beta 2 0.139558
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.13937
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.138926
PEPD peptidase D 0.138884
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.138805
LEPR leptin receptor 0.138769
TGFB3 transforming growth factor, beta 3 0.138069
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.137863
LDHA lactate dehydrogenase A 0.137555
FHIT fragile histidine triad 0.136571
FLNA filamin A, alpha 0.134653
TGFB2 transforming growth factor, beta 2 0.133815
VEGFA vascular endothelial growth factor A 0.132828
MPO myeloperoxidase 0.131747
CD34 CD34 molecule 0.126919
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.118898
FASLG Fas ligand (TNF superfamily, member 6) 0.11823
MLXIPL MLX interacting protein-like 0.117804