vasp Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description vasodilator-stimulated phosphoprotein|Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7408)
Similar Terms
Downloads & Tools

Genes

27 genes co-occuring with the biological term vasp in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABI1 abl-interactor 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTA1 actin, alpha 1, skeletal muscle
BAIAP2 BAI1-associated protein 2
CXCR2 chemokine (C-X-C motif) receptor 2
ENAH enabled homolog (Drosophila)
EPS8 epidermal growth factor receptor pathway substrate 8
EVL Enah/Vasp-like
F2R coagulation factor II (thrombin) receptor
FBLIM1 filamin binding LIM protein 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IRAK1 interleukin-1 receptor-associated kinase 1
LGALS1 lectin, galactoside-binding, soluble, 1
LPAR1 lysophosphatidic acid receptor 1
LPAR2 lysophosphatidic acid receptor 2
LPAR3 lysophosphatidic acid receptor 3
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MIR610 microRNA 610
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PALLD palladin, cytoskeletal associated protein
PRKD1 protein kinase D1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
TNF tumor necrosis factor
VASP vasodilator-stimulated phosphoprotein