vav1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description vav 1 guanine nucleotide exchange factor|This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 7409)
Similar Terms
Downloads & Tools

Genes

48 genes co-occuring with the biological term vav1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BCL2 B-cell CLL/lymphoma 2
BRCA1 breast cancer 1, early onset
CD28 CD28 molecule
CD86 CD86 molecule
CDC25A cell division cycle 25A
CNN1 calponin 1, basic, smooth muscle
CXCL12 chemokine (C-X-C motif) ligand 12
DNM2 dynamin 2
ELAVL1 ELAV like RNA binding protein 1
GP6 glycoprotein VI (platelet)
GRAP GRB2-related adaptor protein
GRAP2 GRB2-related adaptor protein 2
IDO1 indoleamine 2,3-dioxygenase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAT linker for activation of T cells
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
MAP2K3 mitogen-activated protein kinase kinase 3
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NFAM1 NFAT activating protein with ITAM motif 1
PLCG1 phospholipase C, gamma 1
PTK2B protein tyrosine kinase 2 beta
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SPI1 Spi-1 proto-oncogene
SRF serum response factor (c-fos serum response element-binding transcription factor)
STAP2 signal transducing adaptor family member 2
SYK spleen tyrosine kinase
TP73 tumor protein p73
VAV1 vav 1 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa