vdr Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description vitamin D (1,25- dihydroxyvitamin D3) receptor|This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 7421)
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Genes

132 genes co-occuring with the biological term vdr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACAN aggrecan
ALAD aminolevulinate dehydratase
ALOX5 arachidonate 5-lipoxygenase
BMP2 bone morphogenetic protein 2
BMP7 bone morphogenetic protein 7
CALCR calcitonin receptor
CAMP cathelicidin antimicrobial peptide
CASR calcium-sensing receptor
CCND1 cyclin D1
CCND3 cyclin D3
CD209 CD209 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK11B cyclin-dependent kinase 11B
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDX2 caudal type homeobox 2
CNTF ciliary neurotrophic factor
COL1A1 collagen, type I, alpha 1
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKKL1 dickkopf-like 1
DPT dermatopontin
EGFR epidermal growth factor receptor
ERCC2 excision repair cross-complementation group 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FASLG Fas ligand (TNF superfamily, member 6)
FOXP3 forkhead box P3
GATA1 GATA binding protein 1 (globin transcription factor 1)
GC group-specific component (vitamin D binding protein)
GHR growth hormone receptor
HDAC1 histone deacetylase 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HNF4A hepatocyte nuclear factor 4, alpha
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HR hair growth associated
HRH1 histamine receptor H1
HTT huntingtin
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL17A interleukin 17A
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL4 interleukin 4
IPO4 importin 4
IRF5 interferon regulatory factor 5
IRX4 iroquois homeobox 4
JUN jun proto-oncogene
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KDM6B lysine (K)-specific demethylase 6B
KL klotho
KLF4 Kruppel-like factor 4 (gut)
LCT lactase
LEF1 lymphoid enhancer-binding factor 1
LRP2 low density lipoprotein receptor-related protein 2
MAPK14 mitogen-activated protein kinase 14
MED1 mediator complex subunit 1
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NADSYN1 NAD synthetase 1
NCOA2 nuclear receptor coactivator 2
NCOA3 nuclear receptor coactivator 3
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFYA nuclear transcription factor Y, alpha
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NSD1 nuclear receptor binding SET domain protein 1
NUP214 nucleoporin 214kDa
PDGFA platelet-derived growth factor alpha polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLD1 phospholipase D1, phosphatidylcholine-specific
POU1F1 POU class 1 homeobox 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTHLH parathyroid hormone-like hormone
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTX3 pentraxin 3, long
RARA retinoic acid receptor, alpha
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RHOA ras homolog family member A
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RUNX2 runt-related transcription factor 2
RXRA retinoid X receptor, alpha
SIRT1 sirtuin 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SOST sclerostin
SOSTDC1 sclerostin domain containing 1
SPP1 secreted phosphoprotein 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TCF3 transcription factor 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMPRSS2 transmembrane protease, serine 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TPT1 tumor protein, translationally-controlled 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNT1 wingless-type MMTV integration site family, member 1
ZNF410 zinc finger protein 410