vegfa Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description vascular endothelial growth factor A|This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7422)
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Genes

161 genes co-occuring with the biological term vegfa in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
AGTR1 angiotensin II receptor, type 1
AHR aryl hydrocarbon receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANGPTL4 angiopoietin-like 4
AR androgen receptor
ARMS2 age-related maculopathy susceptibility 2
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BMP4 bone morphogenetic protein 4
BMP7 bone morphogenetic protein 7
BRAF B-Raf proto-oncogene, serine/threonine kinase
CAMP cathelicidin antimicrobial peptide
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CFH complement factor H
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLN5 ceroid-lipofuscinosis, neuronal 5
COL10A1 collagen, type X, alpha 1
COL1A2 collagen, type I, alpha 2
CREB1 cAMP responsive element binding protein 1
CREB3L1 cAMP responsive element binding protein 3-like 1
CRP C-reactive protein, pentraxin-related
CSF1 colony stimulating factor 1 (macrophage)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DCN decorin
DLL4 delta-like 4 (Drosophila)
EGR1 early growth response 1
ELAVL1 ELAV like RNA binding protein 1
ENG endoglin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
ESM1 endothelial cell-specific molecule 1
ESR1 estrogen receptor 1
ESRRA estrogen-related receptor alpha
FGF2 fibroblast growth factor 2 (basic)
FGF7 fibroblast growth factor 7
FGF9 fibroblast growth factor 9
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FLT1 fms-related tyrosine kinase 1
FLT4 fms-related tyrosine kinase 4
FOLR1 folate receptor 1 (adult)
FPR2 formyl peptide receptor 2
FPR3 formyl peptide receptor 3
FRK fyn-related Src family tyrosine kinase
GDF5 growth differentiation factor 5
GDNF glial cell derived neurotrophic factor
GLI1 GLI family zinc finger 1
GSK3B glycogen synthase kinase 3 beta
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPL heterogeneous nuclear ribonucleoprotein L
HSPG2 heparan sulfate proteoglycan 2
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
IL17F interleukin 17F
IL1B interleukin 1, beta
IL6 interleukin 6
INS insulin
IRF2BP2 interferon regulatory factor 2 binding protein 2
ISL1 ISL LIM homeobox 1
ITGA1 integrin, alpha 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA9 integrin, alpha 9
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB5 integrin, beta 5
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDM1A lysine (K)-specific demethylase 1A
KDR kinase insert domain receptor
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MDK midkine (neurite growth-promoting factor 2)
MIR125A microRNA 125a
MIR126 microRNA 126
MIR145 microRNA 145
MIR185 microRNA 185
MIR203A microRNA 203a
MIR205 microRNA 205
MIR20A microRNA 20a
MIR26A1 microRNA 26a-1
MIR29A microRNA 29a
MIR361 microRNA 361
MIR503 microRNA 503
MMP1 matrix metallopeptidase 1
MMP11 matrix metallopeptidase 11
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NLRP3 NLR family, pyrin domain containing 3
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOX3 NADPH oxidase 3
NRG1 neuregulin 1
NRP1 neuropilin 1
NRP2 neuropilin 2
OCLN occludin
OTX2 orthodenticle homeobox 2
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PF4 platelet factor 4
PGF placental growth factor
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLA2G10 phospholipase A2, group X
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRKD1 protein kinase D1
PRKD2 protein kinase D2
PROK1 prokineticin 1
PROK2 prokineticin 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RHOA ras homolog family member A
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RWDD3 RWD domain containing 3
S100A13 S100 calcium binding protein A13
SALL1 spalt-like transcription factor 1
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHH sonic hedgehog
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT5A signal transducer and activator of transcription 5A
STC1 stanniocalcin 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGM2 transglutaminase 2
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TNF tumor necrosis factor
TP53 tumor protein p53
TRPS1 trichorhinophalangeal syndrome I
VASH1 vasohibin 1
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
VEGFC vascular endothelial growth factor C
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WT1 Wilms tumor 1
WWOX WW domain containing oxidoreductase
ZMYND8 zinc finger, MYND-type containing 8
ZNF385B zinc finger protein 385B