velnacrine-2430 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the velnacrine-2430 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACAA2 acetyl-CoA acyltransferase 2
ACVR1B activin A receptor, type IB
ADAM12 ADAM metallopeptidase domain 12
ADGRE3 adhesion G protein-coupled receptor E3
AFF3 AF4/FMR2 family, member 3
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AOC2 amine oxidase, copper containing 2 (retina-specific)
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
APLP2 amyloid beta (A4) precursor-like protein 2
CALML3 calmodulin-like 3
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC57 coiled-coil domain containing 57
CLEC2D C-type lectin domain family 2, member D
CLIC5 chloride intracellular channel 5
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COL17A1 collagen, type XVII, alpha 1
COL1A1 collagen, type I, alpha 1
CREM cAMP responsive element modulator
CSF1 colony stimulating factor 1 (macrophage)
CSNK1G1 casein kinase 1, gamma 1
DCT dopachrome tautomerase
DOC2A double C2-like domains, alpha
DOCK1 dedicator of cytokinesis 1
EDRF1 erythroid differentiation regulatory factor 1
ERAP1 endoplasmic reticulum aminopeptidase 1
FAIM2 Fas apoptotic inhibitory molecule 2
FBXL7 F-box and leucine-rich repeat protein 7
FCAR Fc fragment of IgA receptor
FCMR Fc fragment of IgM receptor
FHL2 four and a half LIM domains 2
GK glycerol kinase
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GSN gelsolin
GTF2I general transcription factor IIi
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HIST1H4E histone cluster 1, H4e
HOXA1 homeobox A1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
MBD2 methyl-CpG binding domain protein 2
MET MET proto-oncogene, receptor tyrosine kinase
MFAP3 microfibrillar-associated protein 3
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP25 matrix metallopeptidase 25
MOBP myelin-associated oligodendrocyte basic protein
MRPS12 mitochondrial ribosomal protein S12
MRPS18C mitochondrial ribosomal protein S18C
NCKAP1L NCK-associated protein 1-like
NF2 neurofibromin 2 (merlin)
NOX1 NADPH oxidase 1
NYX nyctalopin
OMD osteomodulin
OSBPL10 oxysterol binding protein-like 10
PAX7 paired box 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCM1 pericentriolar material 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE4C phosphodiesterase 4C, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PRB3 proline-rich protein BstNI subfamily 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRA protein tyrosine phosphatase, receptor type, A
PYGB phosphorylase, glycogen; brain
PYHIN1 pyrin and HIN domain family, member 1
RAB11B RAB11B, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RHOD ras homolog family member D
RNF6 ring finger protein (C3H2C3 type) 6
RUNDC3B RUN domain containing 3B
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SH3GLB2 SH3-domain GRB2-like endophilin B2
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC22A17 solute carrier family 22, member 17
SORBS3 sorbin and SH3 domain containing 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STOML1 stomatin (EPB72)-like 1
SUGP1 SURP and G patch domain containing 1
SULT4A1 sulfotransferase family 4A, member 1
SYCP2 synaptonemal complex protein 2
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TRGV5 T cell receptor gamma variable 5
UBTF upstream binding transcription factor, RNA polymerase I
UBXN1 UBX domain protein 1
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VWA1 von Willebrand factor A domain containing 1
ZNF174 zinc finger protein 174
ZNF205 zinc finger protein 205
ZNF675 zinc finger protein 675

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
AHDC1 AT hook, DNA binding motif, containing 1
ARL15 ADP-ribosylation factor-like 15
AXIN1 axin 1
BTBD18 BTB (POZ) domain containing 18
C11ORF68 chromosome 11 open reading frame 68
C14ORF93 chromosome 14 open reading frame 93
C16ORF59 chromosome 16 open reading frame 59
C5 complement component 5
C9ORF9 chromosome 9 open reading frame 9
CA5BP1 carbonic anhydrase VB pseudogene 1
CAMKMT calmodulin-lysine N-methyltransferase
CCDC176 coiled-coil domain containing 176
CDCP1 CUB domain containing protein 1
CEP170B centrosomal protein 170B
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DGAT1 diacylglycerol O-acyltransferase 1
DOCK4 dedicator of cytokinesis 4
DOK3 docking protein 3
DPEP2 dipeptidase 2
ERAP2 endoplasmic reticulum aminopeptidase 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FEM1C fem-1 homolog c (C. elegans)
FGL1 fibrinogen-like 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GGTLC1 gamma-glutamyltransferase light chain 1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GJA8 gap junction protein, alpha 8, 50kDa
GLCE glucuronic acid epimerase
GNL1 guanine nucleotide binding protein-like 1
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GUSBP3 glucuronidase, beta pseudogene 3
HCAR3 hydroxycarboxylic acid receptor 3
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HLA-DMA major histocompatibility complex, class II, DM alpha
HP haptoglobin
HS1BP3 HCLS1 binding protein 3
HYAL2 hyaluronoglucosaminidase 2
IFI6 interferon, alpha-inducible protein 6
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INF2 inverted formin, FH2 and WH2 domain containing
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
KIAA0319L KIAA0319-like
KLHL21 kelch-like family member 21
LDB1 LIM domain binding 1
LIMD2 LIM domain containing 2
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRC37A2 leucine rich repeat containing 37, member A2
LRRC37A3 leucine rich repeat containing 37, member A3
MAP1S microtubule-associated protein 1S
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MCTP2 multiple C2 domains, transmembrane 2
MED15 mediator complex subunit 15
MEGF8 multiple EGF-like-domains 8
MIR22HG MIR22 host gene
MX2 MX dynamin-like GTPase 2
NABP2 nucleic acid binding protein 2
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NIPAL2 NIPA-like domain containing 2
OVGP1 oviductal glycoprotein 1, 120kDa
PARP16 poly (ADP-ribose) polymerase family, member 16
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PELP1 proline, glutamate and leucine rich protein 1
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PITX2 paired-like homeodomain 2
POM121L2 POM121 transmembrane nucleoporin-like 2
PTDSS2 phosphatidylserine synthase 2
RAB33B RAB33B, member RAS oncogene family
SCG5 secretogranin V
SEC31B SEC31 homolog B (S. cerevisiae)
SH2D4A SH2 domain containing 4A
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMYD5 SMYD family member 5
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STX11 syntaxin 11
SUOX sulfite oxidase
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
THBS3 thrombospondin 3
TIMP2 TIMP metallopeptidase inhibitor 2
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM184B transmembrane protein 184B
TSPAN32 tetraspanin 32
TSPYL2 TSPY-like 2
TTC30A tetratricopeptide repeat domain 30A
VASH1 vasohibin 1
XAB2 XPA binding protein 2
ZC3H3 zinc finger CCCH-type containing 3
ZNF354A zinc finger protein 354A
ZNF493 zinc finger protein 493
ZNF747 zinc finger protein 747