velnacrine-6651 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the velnacrine-6651 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APOF apolipoprotein F
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
AURKC aurora kinase C
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C5AR1 complement component 5a receptor 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD1C CD1c molecule
CD2 CD2 molecule
CD47 CD47 molecule
CD6 CD6 molecule
CDHR2 cadherin-related family member 2
CRYAB crystallin, alpha B
CSHL1 chorionic somatomammotropin hormone-like 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYSLTR2 cysteinyl leukotriene receptor 2
DEFA4 defensin, alpha 4, corticostatin
DMP1 dentin matrix acidic phosphoprotein 1
EDNRB endothelin receptor type B
EFCAB11 EF-hand calcium binding domain 11
ELN elastin
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EREG epiregulin
FABP3 fatty acid binding protein 3, muscle and heart
FLT3LG fms-related tyrosine kinase 3 ligand
FRMPD1 FERM and PDZ domain containing 1
FSCN3 fascin actin-bundling protein 3, testicular
FZD10 frizzled class receptor 10
GJA8 gap junction protein, alpha 8, 50kDa
GLE1 GLE1 RNA export mediator
HEG1 heart development protein with EGF-like domains 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
ITGA7 integrin, alpha 7
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIF21B kinesin family member 21B
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LOC157562 uncharacterized LOC157562
MAP1A microtubule-associated protein 1A
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MTCP1 mature T-cell proliferation 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
N4BP2L2 NEDD4 binding protein 2-like 2
NCOR2 nuclear receptor corepressor 2
NEFM neurofilament, medium polypeptide
NEK9 NIMA-related kinase 9
NIPAL3 NIPA-like domain containing 3
NTNG1 netrin G1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OSBPL10 oxysterol binding protein-like 10
PAX2 paired box 2
PBOV1 prostate and breast cancer overexpressed 1
PCDHB17P protocadherin beta 17 pseudogene
PDE5A phosphodiesterase 5A, cGMP-specific
PKP1 plakophilin 1
PLA2G5 phospholipase A2, group V
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRD protein tyrosine phosphatase, receptor type, D
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASL11B RAS-like, family 11, member B
RGS11 regulator of G-protein signaling 11
RHCE Rh blood group, CcEe antigens
RIMS2 regulating synaptic membrane exocytosis 2
RNF122 ring finger protein 122
RTEL1 regulator of telomere elongation helicase 1
SCAND2P SCAN domain containing 2 pseudogene
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIRT4 sirtuin 4
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLMO1 slowmo homolog 1 (Drosophila)
SORBS1 sorbin and SH3 domain containing 1
SPARCL1 SPARC-like 1 (hevin)
SPRR1A small proline-rich protein 1A
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
SYN3 synapsin III
TFDP3 transcription factor Dp family, member 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSC22D3 TSC22 domain family, member 3
WSB1 WD repeat and SOCS box containing 1
ZCCHC14 zinc finger, CCHC domain containing 14
ZNF362 zinc finger protein 362
ZNF407 zinc finger protein 407
ZNF609 zinc finger protein 609
ZNF613 zinc finger protein 613
ZNF688 zinc finger protein 688

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACADSB acyl-CoA dehydrogenase, short/branched chain
ALPK1 alpha-kinase 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BTF3P11 basic transcription factor 3 pseudogene 11
C9ORF9 chromosome 9 open reading frame 9
CD70 CD70 molecule
CHRDL1 chordin-like 1
CLDN1 claudin 1
CNGB3 cyclic nucleotide gated channel beta 3
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CST1 cystatin SN
CXCL3 chemokine (C-X-C motif) ligand 3
EDAR ectodysplasin A receptor
EDIL3 EGF-like repeats and discoidin I-like domains 3
ELP6 elongator acetyltransferase complex subunit 6
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GAB2 GRB2-associated binding protein 2
GINS4 GINS complex subunit 4 (Sld5 homolog)
HIST1H1D histone cluster 1, H1d
HIST1H3C histone cluster 1, H3c
HOMER2 homer scaffolding protein 2
HOOK1 hook microtubule-tethering protein 1
HOXA1 homeobox A1
HSF2BP heat shock transcription factor 2 binding protein
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
ITK IL2-inducible T-cell kinase
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIRREL kin of IRRE like (Drosophila)
KLF3 Kruppel-like factor 3 (basic)
KRT20 keratin 20, type I
LIPG lipase, endothelial
LMCD1 LIM and cysteine-rich domains 1
LMTK1 lemur tail kinase 1
LOC257152 uncharacterized LOC257152
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LY6G6C lymphocyte antigen 6 complex, locus G6C
LYRM9 LYR motif containing 9
MAGEH1 melanoma antigen family H1
MAP3K7CL MAP3K7 C-terminal like
MBTPS2 membrane-bound transcription factor peptidase, site 2
MMP3 matrix metallopeptidase 3
MNX1 motor neuron and pancreas homeobox 1
MOCS3 molybdenum cofactor synthesis 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NOD1 nucleotide-binding oligomerization domain containing 1
NOL10 nucleolar protein 10
NOL12 nucleolar protein 12
OSR2 odd-skipped related transciption factor 2
OVGP1 oviductal glycoprotein 1, 120kDa
PARP3 poly (ADP-ribose) polymerase family, member 3
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRICKLE3 prickle homolog 3 (Drosophila)
PRSS22 protease, serine, 22
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SAYSD1 SAYSVFN motif domain containing 1
SCEL sciellin
SECTM1 secreted and transmembrane 1
SENP7 SUMO1/sentrin specific peptidase 7
SIRT2 sirtuin 2
SIX3 SIX homeobox 3
SLC16A6 solute carrier family 16, member 6
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SPTBN2 spectrin, beta, non-erythrocytic 2
ST5 suppression of tumorigenicity 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STK16 serine/threonine kinase 16
SYNPO synaptopodin
TADA2A transcriptional adaptor 2A
TAGLN transgelin
THBS3 thrombospondin 3
TLR2 toll-like receptor 2
TMEM121 transmembrane protein 121
TMEM209 transmembrane protein 209
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TOM1 target of myb1 (chicken)
TRAF2 TNF receptor-associated factor 2
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSKU tsukushi, small leucine rich proteoglycan
TTLL1 tubulin tyrosine ligase-like family member 1
TTN titin
TUBA3C tubulin, alpha 3c
TXK TXK tyrosine kinase
UNC93B1 unc-93 homolog B1 (C. elegans)
VEGFB vascular endothelial growth factor B
VGF VGF nerve growth factor inducible
XAB2 XPA binding protein 2
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF141 zinc finger protein 141
ZNF428 zinc finger protein 428
ZNF446 zinc finger protein 446
ZNF675 zinc finger protein 675
ZNF747 zinc finger protein 747
ZNF768 zinc finger protein 768