| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | venetoclax perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the venetoclax_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.205076 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.164139 |
| VIM | vimentin | 0.14563 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.125698 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.100792 |
| ANXA1 | annexin A1 | 0.0870758 |
| MMP12 | matrix metallopeptidase 12 | 0.0845843 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0843682 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0782823 |
| KIF5B | kinesin family member 5B | 0.0698729 |
| NLGN1 | neuroligin 1 | 0.0692296 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.067556 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0669942 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0603489 |
| DST | dystonin | 0.059889 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.057283 |
| ENO1 | enolase 1, (alpha) | 0.0565372 |
| SMC4 | structural maintenance of chromosomes 4 | 0.056146 |
| XPO1 | exportin 1 | 0.0538204 |
| TENM3 | teneurin transmembrane protein 3 | 0.0519112 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0515879 |
| TPI1 | triosephosphate isomerase 1 | 0.0495347 |
| CALR | calreticulin | 0.0491216 |
| HDAC9 | histone deacetylase 9 | 0.0486581 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0484953 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0473026 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0467111 |
| CENPF | centromere protein F, 350/400kDa | 0.0464979 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0441263 |
| LDHA | lactate dehydrogenase A | 0.0409498 |
| CDK6 | cyclin-dependent kinase 6 | 0.0408054 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0406994 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0402751 |
| AREG | amphiregulin | 0.0397142 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0391864 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0389195 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0378063 |
| TMSB10 | thymosin beta 10 | 0.0377801 |
| MKI67 | marker of proliferation Ki-67 | 0.0375133 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0374095 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0364229 |
| ECT2 | epithelial cell transforming 2 | 0.0341501 |
| GOLGB1 | golgin B1 | 0.033176 |
| CLDN1 | claudin 1 | 0.0330442 |
| TPM3 | tropomyosin 3 | 0.0326368 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0321674 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0319925 |
| MPG | N-methylpurine-DNA glycosylase | 0.0312054 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0308287 |
| CANX | calnexin | 0.0307382 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0307235 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0305985 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0305527 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0299793 |
| WWOX | WW domain containing oxidoreductase | 0.0292245 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0292169 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0290812 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0290674 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0287017 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0286668 |
| TPX2 | TPX2, microtubule-associated | 0.028605 |
| ZNF292 | zinc finger protein 292 | 0.0285268 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0283396 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0281841 |
| NEK7 | NIMA-related kinase 7 | 0.0277704 |
| PCM1 | pericentriolar material 1 | 0.0275867 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0273678 |
| PTMA | prothymosin, alpha | 0.0272118 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0272018 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0271869 |
| NEBL | nebulette | 0.0269783 |
| STMN1 | stathmin 1 | 0.0267874 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0267401 |
| YBX1 | Y box binding protein 1 | 0.0257513 |
| PLK2 | polo-like kinase 2 | 0.0257194 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0256097 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0253858 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0253181 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0253017 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0252423 |
| VMP1 | vacuole membrane protein 1 | 0.0250214 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0247012 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.023897 |
| SET | SET nuclear proto-oncogene | 0.0238416 |
| CEP192 | centrosomal protein 192kDa | 0.0236621 |
| PRKCI | protein kinase C, iota | 0.023405 |
| TNPO1 | transportin 1 | 0.0233794 |
| YBX3 | Y box binding protein 3 | 0.0232675 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0232076 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0230707 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0224604 |
| SPAG9 | sperm associated antigen 9 | 0.0221369 |
| SQSTM1 | sequestosome 1 | 0.0221095 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0220901 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0220793 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0220784 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0219658 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.0218633 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0218246 |
| HMGB2 | high mobility group box 2 | 0.0215363 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGR1 | early growth response 1 | -0.077463 |
| NHSL1 | NHS-like 1 | -0.0561968 |
| EHBP1 | EH domain binding protein 1 | -0.0540467 |
| RASAL2 | RAS protein activator like 2 | -0.0506089 |
| ZNF804A | zinc finger protein 804A | -0.0475497 |
| RAB7A | RAB7A, member RAS oncogene family | -0.04465 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.040663 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0393921 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0389825 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.034443 |
| HMGA1 | high mobility group AT-hook 1 | -0.0334596 |
| ACTG1 | actin gamma 1 | -0.031886 |
| NABP1 | nucleic acid binding protein 1 | -0.0307132 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0292603 |
| NAV3 | neuron navigator 3 | -0.0273314 |
| RPL35A | ribosomal protein L35a | -0.0258152 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0256599 |
| ASPH | aspartate beta-hydroxylase | -0.0253768 |
| CCN2 | cellular communication network factor 2 | -0.0235051 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.022902 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0219657 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0219224 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0213804 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0206456 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0204661 |
| HMGA2 | high mobility group AT-hook 2 | -0.0202465 |
| INTS6 | integrator complex subunit 6 | -0.0198381 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0191481 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0188178 |
| FASN | fatty acid synthase | -0.0188017 |
| GPHN | gephyrin | -0.0186632 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0185413 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.018197 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0176706 |
| ANK2 | ankyrin 2, neuronal | -0.0175888 |
| RPS13 | ribosomal protein S13 | -0.0173434 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.0170304 |
| CMIP | c-Maf inducing protein | -0.0164746 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0161585 |
| RPL13A | ribosomal protein L13a | -0.0158722 |
| ATN1 | atrophin 1 | -0.0158053 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.0157538 |
| DIAPH2 | diaphanous-related formin 2 | -0.0154887 |
| RCC1 | regulator of chromosome condensation 1 | -0.015446 |
| RPS21 | ribosomal protein S21 | -0.0152917 |
| MTCL1 | microtubule crosslinking factor 1 | -0.0152085 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -0.0150032 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0147232 |
| RCOR1 | REST corepressor 1 | -0.0143759 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0142316 |
| RPL37A | ribosomal protein L37a | -0.0142024 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0140652 |
| HLA-A | major histocompatibility complex, class I, A | -0.0139374 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0138332 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0132196 |
| SYT1 | synaptotagmin I | -0.0131117 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0129029 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0128994 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0126667 |
| KMT2D | lysine (K)-specific methyltransferase 2D | -0.01261 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0123226 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0122209 |
| CDK17 | cyclin-dependent kinase 17 | -0.0122151 |
| TAPBP | TAP binding protein (tapasin) | -0.0121159 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.012017 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0118532 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0118177 |
| BRD4 | bromodomain containing 4 | -0.0118072 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0116512 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0116226 |
| EGFR | epidermal growth factor receptor | -0.011545 |
| VCAN | versican | -0.0114998 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | -0.011488 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0114033 |
| PCBD2 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 | -0.0111977 |
| SESN2 | sestrin 2 | -0.0110578 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0109661 |
| RPS24 | ribosomal protein S24 | -0.010954 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.01083 |
| COMMD1 | copper metabolism (Murr1) domain containing 1 | -0.0107773 |
| MCL1 | myeloid cell leukemia 1 | -0.0107494 |
| RPS29 | ribosomal protein S29 | -0.0106753 |
| DENND5A | DENN/MADD domain containing 5A | -0.0106438 |
| FOSL1 | FOS-like antigen 1 | -0.0105585 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0104666 |
| RPL31 | ribosomal protein L31 | -0.0104127 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0104095 |
| NLK | nemo-like kinase | -0.0103828 |
| FADS2 | fatty acid desaturase 2 | -0.0103439 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0102066 |
| RPL34 | ribosomal protein L34 | -0.0101043 |
| DENND1A | DENN/MADD domain containing 1A | -0.00997397 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.00997324 |
| HSPB1 | heat shock 27kDa protein 1 | -0.00997297 |
| KSR2 | kinase suppressor of ras 2 | -0.00975445 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.00966104 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.00964332 |
| RPL28 | ribosomal protein L28 | -0.00961953 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.00958452 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.00952263 |
