venetoclax_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description venetoclax perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the venetoclax_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.170402
FMN1 formin 1 0.145991
PRKCA protein kinase C, alpha 0.102453
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0942046
NRG1 neuregulin 1 0.0903586
EXT1 exostosin glycosyltransferase 1 0.0838214
LSAMP limbic system-associated membrane protein 0.0809365
PTPRD protein tyrosine phosphatase, receptor type, D 0.077402
ZSWIM6 zinc finger, SWIM-type containing 6 0.0757851
MSI2 musashi RNA-binding protein 2 0.0631911
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.056628
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0523305
SLIT2 slit homolog 2 (Drosophila) 0.0485765
FNDC3B fibronectin type III domain containing 3B 0.047531
DST dystonin 0.0462806
TLE4 transducin-like enhancer of split 4 0.0452186
PTPRK protein tyrosine phosphatase, receptor type, K 0.0450309
LINGO2 leucine rich repeat and Ig domain containing 2 0.044263
NALF1 NALCN channel auxiliary factor 1 0.0437427
AUTS2 autism susceptibility candidate 2 0.0423495
FERMT2 fermitin family member 2 0.0414516
VMP1 vacuole membrane protein 1 0.0407739
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0400977
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0390795
INTS6 integrator complex subunit 6 0.0381519
THSD4 thrombospondin, type I, domain containing 4 0.0380634
GREM2 gremlin 2, DAN family BMP antagonist 0.0376265
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0365569
FAM107B family with sequence similarity 107, member B 0.036094
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0352762
ZNF804A zinc finger protein 804A 0.0346621
SLITRK6 SLIT and NTRK-like family, member 6 0.0341489
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0338983
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0331359
LIMA1 LIM domain and actin binding 1 0.0327864
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0323367
MED13 mediator complex subunit 13 0.0323229
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.03195
ENAH enabled homolog (Drosophila) 0.0311238
TIMP3 TIMP metallopeptidase inhibitor 3 0.0307802
TCF12 transcription factor 12 0.0305184
GLCCI1 glucocorticoid induced 1 0.0299913
TPM4 tropomyosin 4 0.0293116
SP100 SP100 nuclear antigen 0.0292443
DGKH diacylglycerol kinase, eta 0.0287904
TPST1 tyrosylprotein sulfotransferase 1 0.0286732
GPBP1 GC-rich promoter binding protein 1 0.0286546
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0285937
RNF213 ring finger protein 213 0.0285783
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0284408
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0282572
NPAS2 neuronal PAS domain protein 2 0.0280309
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0279471
MYO1E myosin IE 0.0277217
SMYD3 SET and MYND domain containing 3 0.0275923
CRH corticotropin releasing hormone 0.0275384
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0274081
MYH9 myosin, heavy chain 9, non-muscle 0.0273931
PDLIM5 PDZ and LIM domain 5 0.0273654
LPP LIM domain containing preferred translocation partner in lipoma 0.0269079
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0268364
RAD51B RAD51 paralog B 0.0266996
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0265052
FNDC3A fibronectin type III domain containing 3A 0.0264849
ZC3H11A zinc finger CCCH-type containing 11A 0.0262983
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.0260783
STK38L serine/threonine kinase 38 like 0.0259934
TPM1 tropomyosin 1 (alpha) 0.0259343
MRTFA myocardin related transcription factor A 0.0255437
UNC5C unc-5 homolog C (C. elegans) 0.0253029
WAC WW domain containing adaptor with coiled-coil 0.0251965
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0247555
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0244722
PCDH15 protocadherin-related 15 0.0243646
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0241395
SYT1 synaptotagmin I 0.0240508
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0239959
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0238622
CADM2 cell adhesion molecule 2 0.0237942
TAS2R14 taste receptor, type 2, member 14 0.0237021
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.02368
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.023525
RIGI RNA sensor RIG-I 0.0234484
FRMD5 FERM domain containing 5 0.0234157
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0233947
SCFD1 sec1 family domain containing 1 0.0233522
KLHL13 kelch-like family member 13 0.0233349
PSD3 pleckstrin and Sec7 domain containing 3 0.0232382
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0231948
STXBP4 syntaxin binding protein 4 0.0228403
DACH2 dachshund family transcription factor 2 0.0223923
CPED1 cadherin-like and PC-esterase domain containing 1 0.0222065
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0221665
SOS1 son of sevenless homolog 1 (Drosophila) 0.0220498
COL4A5 collagen, type IV, alpha 5 0.0218076
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0216744
RALYL RALY RNA binding protein-like 0.0215957
ASPH aspartate beta-hydroxylase 0.0215788
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0215658
RABGAP1L RAB GTPase activating protein 1-like 0.0213759

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.449331
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.262467
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0649343
VIM vimentin -0.0608113
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0477098
RPS6 ribosomal protein S6 -0.0399809
RPLP1 ribosomal protein, large, P1 -0.0395232
NDRG1 N-myc downstream regulated 1 -0.0391671
RPL35A ribosomal protein L35a -0.0388518
COL1A1 collagen, type I, alpha 1 -0.0388105
TMSB10 thymosin beta 10 -0.0358656
RPL38 ribosomal protein L38 -0.0354955
RPL19 ribosomal protein L19 -0.0335786
PTMA prothymosin, alpha -0.0328567
ACTG1 actin gamma 1 -0.0307521
B2M beta-2-microglobulin -0.030709
PKM pyruvate kinase, muscle -0.0305908
TBX2 T-box 2 -0.0265578
GATA3 GATA binding protein 3 -0.0259244
RPS23 ribosomal protein S23 -0.0257598
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0252064
HAND2 heart and neural crest derivatives expressed 2 -0.0248679
RPL32 ribosomal protein L32 -0.0244461
PHOX2B paired-like homeobox 2b -0.0242932
WDR45B WD repeat domain 45B -0.0237811
RPS15 ribosomal protein S15 -0.0231392
S100A6 S100 calcium binding protein A6 -0.0229261
STC1 stanniocalcin 1 -0.0229115
RUNX1 runt-related transcription factor 1 -0.0226573
DCAF7 DDB1 and CUL4 associated factor 7 -0.0214693
SMAD3 SMAD family member 3 -0.0212301
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0211533
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0209774
RPS19 ribosomal protein S19 -0.0209267
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0209075
RPS29 ribosomal protein S29 -0.0206093
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0204224
FTL ferritin, light polypeptide -0.0203818
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0201671
S100A9 S100 calcium binding protein A9 -0.0200991
RPLP0 ribosomal protein, large, P0 -0.0199933
NAMPT nicotinamide phosphoribosyltransferase -0.0199156
GNAS GNAS complex locus -0.0197527
RPL37A ribosomal protein L37a -0.0194284
RPL13A ribosomal protein L13a -0.0194095
IER3 immediate early response 3 -0.0192528
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0192179
RPS5 ribosomal protein S5 -0.0187285
KLHL24 kelch-like family member 24 -0.0185287
MEF2D myocyte enhancer factor 2D -0.0184203
RPS14 ribosomal protein S14 -0.0182498
IGFBP4 insulin-like growth factor binding protein 4 -0.0179482
HMGA1 high mobility group AT-hook 1 -0.0179309
FNBP1 formin binding protein 1 -0.0179055
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0178783
RPL15 ribosomal protein L15 -0.0177301
RPS21 ribosomal protein S21 -0.0176059
FOXO3 forkhead box O3 -0.0175619
RPLP2 ribosomal protein, large, P2 -0.0175363
RPL28 ribosomal protein L28 -0.0173909
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0172571
FTH1 ferritin, heavy polypeptide 1 -0.0168783
HAS2 hyaluronan synthase 2 -0.0168399
LMNA lamin A/C -0.0167995
ZNFX1 zinc finger, NFX1-type containing 1 -0.0167379
NCOR2 nuclear receptor corepressor 2 -0.0165601
SCAF11 SR-related CTD-associated factor 11 -0.0165551
EGR1 early growth response 1 -0.0165516
ATP5F1B ATP synthase F1 subunit beta -0.0164349
DEK DEK proto-oncogene -0.0164094
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0162965
PRR11 proline rich 11 -0.0162348
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0160875
PFN1 profilin 1 -0.0160121
RPS10 ribosomal protein S10 -0.0158651
RPL34 ribosomal protein L34 -0.0154388
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0154367
FBXL20 F-box and leucine-rich repeat protein 20 -0.0154228
RPL11 ribosomal protein L11 -0.0153972
WSB1 WD repeat and SOCS box containing 1 -0.0153498
TAPBP TAP binding protein (tapasin) -0.0153348
GCC2 GRIP and coiled-coil domain containing 2 -0.0152095
RPS11 ribosomal protein S11 -0.0151841
RPL36 ribosomal protein L36 -0.0151386
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0151096
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0146829
RBM20 RNA binding motif protein 20 -0.0144631
GOSR1 golgi SNAP receptor complex member 1 -0.0144142
TP53 tumor protein p53 -0.0143569
TNRC6B trinucleotide repeat containing 6B -0.0143032
RPL8 ribosomal protein L8 -0.014141
MDK midkine (neurite growth-promoting factor 2) -0.0140785
MT2A metallothionein 2A -0.0140178
SCLT1 sodium channel and clathrin linker 1 -0.0139941
RARA retinoic acid receptor, alpha -0.0139404
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0138847
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -0.0138303
MXI1 MAX interactor 1, dimerization protein -0.0136742
COL6A1 collagen, type VI, alpha 1 -0.013669
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0136525