venetoclax_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description venetoclax perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the venetoclax_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.319419
MT2A metallothionein 2A 0.117739
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.106594
LDHA lactate dehydrogenase A 0.10518
CD44 CD44 molecule (Indian blood group) 0.0930441
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0896489
ENO1 enolase 1, (alpha) 0.0879136
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0776102
ASPH aspartate beta-hydroxylase 0.0768143
ALCAM activated leukocyte cell adhesion molecule 0.0742842
EXT1 exostosin glycosyltransferase 1 0.0704243
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0693818
INHBA inhibin, beta A 0.0673172
SOD2 superoxide dismutase 2, mitochondrial 0.0664283
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0652226
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0647442
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0555981
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0532973
ARRDC3 arrestin domain containing 3 0.0494076
VIM vimentin 0.0493844
CANX calnexin 0.0474011
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0470342
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0462654
FNDC3B fibronectin type III domain containing 3B 0.045364
VCAN versican 0.0442065
SAMD9 sterile alpha motif domain containing 9 0.0440243
IGFBP7 insulin-like growth factor binding protein 7 0.0439478
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0437437
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0433218
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0433155
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0425732
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0424856
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0420582
RIGI RNA sensor RIG-I 0.0419637
GOLGB1 golgin B1 0.0418499
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0418399
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0412838
WWTR1 WW domain containing transcription regulator 1 0.0412696
FTH1 ferritin, heavy polypeptide 1 0.0396615
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0395174
SP100 SP100 nuclear antigen 0.0384312
RB1CC1 RB1-inducible coiled-coil 1 0.0373146
STC1 stanniocalcin 1 0.0370099
ERRFI1 ERBB receptor feedback inhibitor 1 0.0361593
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0355884
MBNL1 muscleblind-like splicing regulator 1 0.0352673
FAM107B family with sequence similarity 107, member B 0.0350498
RAD21 RAD21 homolog (S. pombe) 0.034754
IL6ST interleukin 6 signal transducer 0.0339625
MLF1 myeloid leukemia factor 1 0.0339557
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0338843
LTBP1 latent transforming growth factor beta binding protein 1 0.0336209
NAV2 neuron navigator 2 0.0335374
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0334617
CALU calumenin 0.033444
SPAG9 sperm associated antigen 9 0.0306102
ZBTB20 zinc finger and BTB domain containing 20 0.0302879
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0299653
MYH9 myosin, heavy chain 9, non-muscle 0.0297293
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0293681
POSTN periostin, osteoblast specific factor 0.0289763
ZBTB38 zinc finger and BTB domain containing 38 0.0287921
TNIP1 TNFAIP3 interacting protein 1 0.0276552
COL3A1 collagen, type III, alpha 1 0.0273898
HSPA8 heat shock 70kDa protein 8 0.0272894
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0266717
SERINC1 serine incorporator 1 0.026382
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.026366
ATP13A3 ATPase type 13A3 0.0262105
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0261006
BZW1 basic leucine zipper and W2 domains 1 0.0257005
TMSB4X thymosin beta 4, X-linked 0.0256288
ECE1 endothelin converting enzyme 1 0.025326
SMAD3 SMAD family member 3 0.0249241
CENPF centromere protein F, 350/400kDa 0.0248837
SQSTM1 sequestosome 1 0.0246161
IRAK2 interleukin-1 receptor-associated kinase 2 0.024481
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0242251
COL1A2 collagen, type I, alpha 2 0.0238956
MTSS1 metastasis suppressor 1 0.0238619
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0236655
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.023028
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.022797
ELL2 elongation factor, RNA polymerase II, 2 0.0227292
MYO10 myosin X 0.0224691
COL4A1 collagen, type IV, alpha 1 0.0217906
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0217682
IQGAP1 IQ motif containing GTPase activating protein 1 0.0216322
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0215741
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0214001
KDM7A lysine (K)-specific demethylase 7A 0.021191
AKAP9 A kinase (PRKA) anchor protein 9 0.0211137
RASA2 RAS p21 protein activator 2 0.0210436
ANKRD28 ankyrin repeat domain 28 0.0210257
BIRC3 baculoviral IAP repeat containing 3 0.0207914
SERINC3 serine incorporator 3 0.0202737
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.020162
CAV1 caveolin 1, caveolae protein, 22kDa 0.0201363
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0199803
ATL1 atlastin GTPase 1 0.0199125

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.298495
NDRG1 N-myc downstream regulated 1 -0.250941
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.123455
COL1A1 collagen, type I, alpha 1 -0.118862
TGFBI transforming growth factor, beta-induced, 68kDa -0.103976
COL5A1 collagen, type V, alpha 1 -0.103249
COL6A3 collagen, type VI, alpha 3 -0.101568
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0862442
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0825295
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0770346
RPL35A ribosomal protein L35a -0.0767314
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0598673
VEGFA vascular endothelial growth factor A -0.0597342
CCDC80 coiled-coil domain containing 80 -0.0571404
COL7A1 collagen, type VII, alpha 1 -0.0555784
TMSB10 thymosin beta 10 -0.0537234
PSD3 pleckstrin and Sec7 domain containing 3 -0.0521139
RPS8 ribosomal protein S8 -0.0493363
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0475523
FTL ferritin, light polypeptide -0.0439908
ENO2 enolase 2 (gamma, neuronal) -0.0431458
SMYD3 SET and MYND domain containing 3 -0.0415161
GARS1 glycyl-tRNA synthetase 1 -0.0394464
PTMA prothymosin, alpha -0.03902
MTDH metadherin -0.0388923
RPL36 ribosomal protein L36 -0.0386781
ANKRD11 ankyrin repeat domain 11 -0.0374792
RPLP2 ribosomal protein, large, P2 -0.0349752
RPS19 ribosomal protein S19 -0.0346753
COL6A1 collagen, type VI, alpha 1 -0.0346087
GOLGA4 golgin A4 -0.0343875
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0340397
ACTG1 actin gamma 1 -0.0339116
RPL37A ribosomal protein L37a -0.0336893
COL6A2 collagen, type VI, alpha 2 -0.0336643
MAP4 microtubule-associated protein 4 -0.0336155
FRMD5 FERM domain containing 5 -0.0335246
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0313584
RPL28 ribosomal protein L28 -0.031297
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0312624
RPS6 ribosomal protein S6 -0.0309098
HLA-B major histocompatibility complex, class I, B -0.030501
GLIS3 GLIS family zinc finger 3 -0.0302049
RPS3 ribosomal protein S3 -0.0298998
RRBP1 ribosome binding protein 1 -0.0296813
RTN4 reticulon 4 -0.0290623
RPL5 ribosomal protein L5 -0.0288139
RAB6A RAB6A, member RAS oncogene family -0.0286555
RPS13 ribosomal protein S13 -0.0285309
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0285051
DPYD dihydropyrimidine dehydrogenase -0.0284325
EGR1 early growth response 1 -0.0283803
TPT1 tumor protein, translationally-controlled 1 -0.0282904
AAK1 AP2 associated kinase 1 -0.0275555
CADM1 cell adhesion molecule 1 -0.0273909
F3 coagulation factor III (thromboplastin, tissue factor) -0.0271735
JARID2 jumonji, AT rich interactive domain 2 -0.0267487
S100A9 S100 calcium binding protein A9 -0.0266614
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0264501
DLG1 discs, large homolog 1 (Drosophila) -0.0263544
TRPS1 trichorhinophalangeal syndrome I -0.0263445
TSC22D2 TSC22 domain family, member 2 -0.0260992
LOXL2 lysyl oxidase-like 2 -0.0255937
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0252458
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0242008
FGFR1 fibroblast growth factor receptor 1 -0.0241756
WSB1 WD repeat and SOCS box containing 1 -0.0240289
RPL31 ribosomal protein L31 -0.0237859
RPS27A ribosomal protein S27a -0.0235542
RPL23 ribosomal protein L23 -0.0232208
ZFAND3 zinc finger, AN1-type domain 3 -0.0228816
FOXP1 forkhead box P1 -0.0224365
HSPG2 heparan sulfate proteoglycan 2 -0.0222083
EIF5B eukaryotic translation initiation factor 5B -0.0221095
KDM4B lysine (K)-specific demethylase 4B -0.0218925
ANO10 anoctamin 10 -0.0217709
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0216719
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0216235
FKBP10 FK506 binding protein 10, 65 kDa -0.0215098
ACTN4 actinin, alpha 4 -0.0214713
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0213803
DOCK5 dedicator of cytokinesis 5 -0.0212066
RPL9 ribosomal protein L9 -0.0211357
SESN2 sestrin 2 -0.0209838
PRKCA protein kinase C, alpha -0.0206103
RPS12 ribosomal protein S12 -0.0206057
FLNA filamin A, alpha -0.0204375
PLEC plectin -0.0203046
RPL26 ribosomal protein L26 -0.0200523
TENM3 teneurin transmembrane protein 3 -0.0200152
HM13 histocompatibility (minor) 13 -0.019963
RPS21 ribosomal protein S21 -0.0198912
RAB7A RAB7A, member RAS oncogene family -0.0198412
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0198003
RPL11 ribosomal protein L11 -0.0197606
NUCB2 nucleobindin 2 -0.0196495
TMEM165 transmembrane protein 165 -0.019643
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0196417
LAMA5 laminin, alpha 5 -0.019612
HLA-A major histocompatibility complex, class I, A -0.0195047