venetoclax_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description venetoclax perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the venetoclax_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.20061
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.151121
DSPP dentin sialophosphoprotein 0.140642
AKAP12 A kinase (PRKA) anchor protein 12 0.126536
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.103684
SVIL supervillin 0.100593
SAMD4A sterile alpha motif domain containing 4A 0.0980855
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0921524
FN1 fibronectin 1 0.0782616
DST dystonin 0.0771041
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0759995
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0724334
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0717498
EHBP1 EH domain binding protein 1 0.0694399
GPC6 glypican 6 0.0676356
ASPH aspartate beta-hydroxylase 0.0653695
ENO1 enolase 1, (alpha) 0.0649874
FNDC3B fibronectin type III domain containing 3B 0.0622405
EXT1 exostosin glycosyltransferase 1 0.0572766
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0571198
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0562312
DOCK4 dedicator of cytokinesis 4 0.0552687
TRIO trio Rho guanine nucleotide exchange factor 0.0545184
IGFBP1 insulin-like growth factor binding protein 1 0.0542828
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0525902
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0525148
PAWR PRKC, apoptosis, WT1, regulator 0.052156
MAML2 mastermind-like 2 (Drosophila) 0.0513172
ATXN1 ataxin 1 0.0511857
ELL2 elongation factor, RNA polymerase II, 2 0.0505178
PDLIM5 PDZ and LIM domain 5 0.0493214
FAM107B family with sequence similarity 107, member B 0.0486709
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0470508
MBNL2 muscleblind-like splicing regulator 2 0.0458858
FOXP1 forkhead box P1 0.0457192
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0456406
JMJD1C jumonji domain containing 1C 0.0448084
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.04423
ITGAV integrin, alpha V 0.0434517
AFDN afadin, adherens junction formation factor 0.0413731
CCL20 chemokine (C-C motif) ligand 20 0.0406565
PEG3 paternally expressed 3 0.0391918
MBNL1 muscleblind-like splicing regulator 1 0.0389751
SLC38A2 solute carrier family 38, member 2 0.0386769
FRMD5 FERM domain containing 5 0.0385374
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0385017
FAT1 FAT atypical cadherin 1 0.038482
AHR aryl hydrocarbon receptor 0.0381796
SESTD1 SEC14 and spectrin domains 1 0.0377125
LCOR ligand dependent nuclear receptor corepressor 0.0368197
MACF1 microtubule-actin crosslinking factor 1 0.0361819
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0350826
KYNU kynureninase 0.0346985
RASA2 RAS p21 protein activator 2 0.0337924
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0322526
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0320196
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0315884
AFF1 AF4/FMR2 family, member 1 0.0306672
PHF3 PHD finger protein 3 0.0298076
CRY1 cryptochrome circadian clock 1 0.0293892
APLP2 amyloid beta (A4) precursor-like protein 2 0.0290917
ANO6 anoctamin 6 0.0286189
DSTN destrin (actin depolymerizing factor) 0.0285513
CEMIP2 cell migration inducing hyaluronidase 2 0.0282938
VMP1 vacuole membrane protein 1 0.0279643
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0278127
ZBTB20 zinc finger and BTB domain containing 20 0.0276726
STAU1 staufen double-stranded RNA binding protein 1 0.0271868
ZNF644 zinc finger protein 644 0.0271815
KIAA1217 KIAA1217 0.0271202
TXNRD1 thioredoxin reductase 1 0.0270238
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0267782
DSCAM Down syndrome cell adhesion molecule 0.0264347
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0263108
CADM1 cell adhesion molecule 1 0.0262021
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0260961
GK glycerol kinase 0.0256889
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0253515
FMNL2 formin-like 2 0.025335
WWC2 WW and C2 domain containing 2 0.0252229
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0251279
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.025071
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0250189
DENND4A DENN/MADD domain containing 4A 0.0248287
SMAD3 SMAD family member 3 0.0245219
GRB10 growth factor receptor-bound protein 10 0.0244458
CPE carboxypeptidase E 0.0244081
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0243325
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.024312
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0242285
USP47 ubiquitin specific peptidase 47 0.0240893
BIRC6 baculoviral IAP repeat containing 6 0.023848
KDM3A lysine (K)-specific demethylase 3A 0.023767
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0235124
STK17A serine/threonine kinase 17a 0.0234627
RAI14 retinoic acid induced 14 0.0233139
AKAP13 A kinase (PRKA) anchor protein 13 0.0232953
ARHGAP21 Rho GTPase activating protein 21 0.0232162
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0231762
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0230955

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.513727
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.139662
C3 complement component 3 -0.103087
FTL ferritin, light polypeptide -0.0812231
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0703306
RPL35A ribosomal protein L35a -0.0589699
RPL37A ribosomal protein L37a -0.0588189
RPS12 ribosomal protein S12 -0.0587755
RPS6 ribosomal protein S6 -0.0498231
APOA2 apolipoprotein A-II -0.0489338
CFB complement factor B -0.0447511
RPS19 ribosomal protein S19 -0.0439589
RPS8 ribosomal protein S8 -0.0434095
RPLP2 ribosomal protein, large, P2 -0.0413883
RPS27A ribosomal protein S27a -0.0397486
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.03948
PTMA prothymosin, alpha -0.0386815
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0378753
RPL23 ribosomal protein L23 -0.0374145
RPL12 ribosomal protein L12 -0.0371447
RPL31 ribosomal protein L31 -0.0370064
RPL36 ribosomal protein L36 -0.0370008
RPS3 ribosomal protein S3 -0.0364197
RPL9 ribosomal protein L9 -0.0336811
TPT1 tumor protein, translationally-controlled 1 -0.0323953
APOE apolipoprotein E -0.0314058
RPL11 ribosomal protein L11 -0.0301502
APOA1 apolipoprotein A-I -0.0296864
RPS29 ribosomal protein S29 -0.0294074
RPL26 ribosomal protein L26 -0.029136
RPLP1 ribosomal protein, large, P1 -0.0282737
HMGA1 high mobility group AT-hook 1 -0.0274958
LRMDA leucine rich melanocyte differentiation associated -0.0272998
RPS13 ribosomal protein S13 -0.0270283
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0270117
RPL34 ribosomal protein L34 -0.0268959
B2M beta-2-microglobulin -0.0268941
EEF2 eukaryotic translation elongation factor 2 -0.0259411
RPL27 ribosomal protein L27 -0.0256671
DDIT4 DNA-damage-inducible transcript 4 -0.0251491
RPL38 ribosomal protein L38 -0.0248149
RPL19 ribosomal protein L19 -0.0240951
RPS24 ribosomal protein S24 -0.0237585
IFI6 interferon, alpha-inducible protein 6 -0.0229127
RPS23 ribosomal protein S23 -0.0228514
HLA-A major histocompatibility complex, class I, A -0.0222549
RPL37 ribosomal protein L37 -0.0219767
RPS10 ribosomal protein S10 -0.0218372
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0216586
RPS21 ribosomal protein S21 -0.0214924
LCN2 lipocalin 2 -0.0212807
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0209937
IL32 interleukin 32 -0.0209592
RPL5 ribosomal protein L5 -0.0204844
RPS17 ribosomal protein S17 -0.0195578
RPL28 ribosomal protein L28 -0.0195018
HLA-B major histocompatibility complex, class I, B -0.0189579
RPS14 ribosomal protein S14 -0.0187063
APOC1 apolipoprotein C-I -0.0182648
WSB1 WD repeat and SOCS box containing 1 -0.0181843
GNAS GNAS complex locus -0.017639
EIF5B eukaryotic translation initiation factor 5B -0.0176359
RPL36A ribosomal protein L36a -0.0169631
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0168762
RPL7A ribosomal protein L7a -0.0168498
ANGPTL8 angiopoietin like 8 -0.016604
S100A9 S100 calcium binding protein A9 -0.0164349
PKM pyruvate kinase, muscle -0.016195
ANXA4 annexin A4 -0.0161512
RPL30 ribosomal protein L30 -0.0158816
RPS25 ribosomal protein S25 -0.0158384
RCAN1 regulator of calcineurin 1 -0.0158287
RPL35 ribosomal protein L35 -0.0157078
RPS5 ribosomal protein S5 -0.015702
APOC3 apolipoprotein C-III -0.0156367
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0154952
ACTG1 actin gamma 1 -0.0154744
RPS27 ribosomal protein S27 -0.0152843
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0150398
RACK1 receptor for activated C kinase 1 -0.0149861
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0149857
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0145731
TMSB10 thymosin beta 10 -0.0144015
RPL10A ribosomal protein L10a -0.0141027
FBXO17 F-box protein 17 -0.0135943
FABP1 fatty acid binding protein 1, liver -0.0135123
ENO2 enolase 2 (gamma, neuronal) -0.0134733
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0134388
NDRG1 N-myc downstream regulated 1 -0.0133903
VDAC1 voltage-dependent anion channel 1 -0.0133243
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0133036
RPL13A ribosomal protein L13a -0.0132996
RPS11 ribosomal protein S11 -0.0132925
ICAM1 intercellular adhesion molecule 1 -0.0132162
MT2A metallothionein 2A -0.0132041
RPL27A ribosomal protein L27a -0.0130783
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0130223
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0130203
CTSD cathepsin D -0.0125993
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0125529