venetoclax_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description venetoclax perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the venetoclax_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.204093
LMO7 LIM domain 7 0.100976
PTPRK protein tyrosine phosphatase, receptor type, K 0.0680979
AHR aryl hydrocarbon receptor 0.0526075
FNDC3B fibronectin type III domain containing 3B 0.052282
ATXN1 ataxin 1 0.0510821
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0506253
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0500257
MBNL2 muscleblind-like splicing regulator 2 0.04966
GMDS GDP-mannose 4,6-dehydratase 0.0433997
EXT1 exostosin glycosyltransferase 1 0.0411108
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0409128
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0399154
LPP LIM domain containing preferred translocation partner in lipoma 0.0390646
MACC1 metastasis associated in colon cancer 1 0.0375337
ASPH aspartate beta-hydroxylase 0.0373554
DSPP dentin sialophosphoprotein 0.0360194
MYOF myoferlin 0.0359298
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0353497
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0352544
EFNA5 ephrin-A5 0.0350513
CDK6 cyclin-dependent kinase 6 0.0347152
POF1B premature ovarian failure, 1B 0.0336715
COBL cordon-bleu WH2 repeat protein 0.0335447
EZR ezrin 0.0334535
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0333414
PLSCR1 phospholipid scramblase 1 0.0317534
SIK3 SIK family kinase 3 0.0315603
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0314857
AKAP13 A kinase (PRKA) anchor protein 13 0.0314796
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0311976
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0310593
EXOC4 exocyst complex component 4 0.0305131
ZSWIM6 zinc finger, SWIM-type containing 6 0.0297478
EHBP1 EH domain binding protein 1 0.0297065
GDA guanine deaminase 0.0295174
RNF213 ring finger protein 213 0.0290398
RASEF RAS and EF-hand domain containing 0.0285256
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0284547
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0280397
TMC5 transmembrane channel-like 5 0.0279856
SH3RF1 SH3 domain containing ring finger 1 0.0279128
HSPA8 heat shock 70kDa protein 8 0.027776
NCEH1 neutral cholesterol ester hydrolase 1 0.0276646
MCU mitochondrial calcium uniporter 0.0276477
KLF5 Kruppel-like factor 5 (intestinal) 0.0268761
DST dystonin 0.0268458
CEMIP2 cell migration inducing hyaluronidase 2 0.026782
FNIP1 folliculin interacting protein 1 0.0260474
TJP1 tight junction protein 1 0.0255082
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0252983
MAML2 mastermind-like 2 (Drosophila) 0.0251327
DOCK5 dedicator of cytokinesis 5 0.0250827
MBNL1 muscleblind-like splicing regulator 1 0.0249874
PDLIM5 PDZ and LIM domain 5 0.0248511
GOLGB1 golgin B1 0.0245642
RAD51B RAD51 paralog B 0.0245585
MTUS1 microtubule associated tumor suppressor 1 0.024325
SP100 SP100 nuclear antigen 0.023948
RUNX1 runt-related transcription factor 1 0.0238937
MYH9 myosin, heavy chain 9, non-muscle 0.0231987
CDK13 cyclin-dependent kinase 13 0.0230563
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.02301
ARHGAP32 Rho GTPase activating protein 32 0.0217949
ERRFI1 ERBB receptor feedback inhibitor 1 0.0217464
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0212341
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0211089
GCLC glutamate-cysteine ligase, catalytic subunit 0.0207776
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0206906
MYO1E myosin IE 0.0206388
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0206041
SMAD3 SMAD family member 3 0.0204652
ATF7IP2 activating transcription factor 7 interacting protein 2 0.0200273
WWOX WW domain containing oxidoreductase 0.0199106
CNKSR3 CNKSR family member 3 0.0197953
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0197048
CTBP2 C-terminal binding protein 2 0.0195368
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0194327
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0191993
CD2AP CD2-associated protein 0.018996
SERINC5 serine incorporator 5 0.0189167
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.018817
BTBD9 BTB (POZ) domain containing 9 0.0185825
SHROOM3 shroom family member 3 0.0185096
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0183271
CANX calnexin 0.0183082
ZBTB20 zinc finger and BTB domain containing 20 0.0182852
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0181698
NFIB nuclear factor I/B 0.0180032
CADPS2 Ca++-dependent secretion activator 2 0.0179329
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0177964
IL1RAP interleukin 1 receptor accessory protein 0.0176051
FOXP1 forkhead box P1 0.0175978
MX1 MX dynamin-like GTPase 1 0.0174073
INTS6 integrator complex subunit 6 0.0173968
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0172403
CATSPERB catsper channel auxiliary subunit beta 0.0171426
ZC3H12B zinc finger CCCH-type containing 12B 0.0171138
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0169345
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0169195

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.182227
TMSB10 thymosin beta 10 -0.166788
POTEF POTE ankyrin domain family, member F -0.0998697
RPL35A ribosomal protein L35a -0.0937629
RPS6 ribosomal protein S6 -0.0882154
NPSR1 neuropeptide S receptor 1 -0.0848651
S100A6 S100 calcium binding protein A6 -0.0847579
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0838472
PTMA prothymosin, alpha -0.0814675
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0810272
TPT1 tumor protein, translationally-controlled 1 -0.0743885
FTL ferritin, light polypeptide -0.0738187
NDRG1 N-myc downstream regulated 1 -0.0721311
B2M beta-2-microglobulin -0.0695915
RPS19 ribosomal protein S19 -0.0666267
RPL23 ribosomal protein L23 -0.0658313
EIF1 eukaryotic translation initiation factor 1 -0.0647293
RPS3 ribosomal protein S3 -0.0640054
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0607987
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0598099
S100A10 S100 calcium binding protein A10 -0.0562579
RPLP1 ribosomal protein, large, P1 -0.055671
LOC112694756 uncharaterized LOC112694756 -0.053195
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0524748
PKM pyruvate kinase, muscle -0.0518148
HLA-A major histocompatibility complex, class I, A -0.0509671
HMGA1 high mobility group AT-hook 1 -0.0501012
RPS21 ribosomal protein S21 -0.0497438
RPL12 ribosomal protein L12 -0.0493547
S100A9 S100 calcium binding protein A9 -0.0489621
CLDN7 claudin 7 -0.0441384
AGR2 anterior gradient 2 -0.0439244
RPS25 ribosomal protein S25 -0.0429703
RPL19 ribosomal protein L19 -0.0424959
RPS8 ribosomal protein S8 -0.0420178
ACTG1 actin gamma 1 -0.0413666
ITGB4 integrin, beta 4 -0.0413387
S100A11 S100 calcium binding protein A11 -0.0405647
RPL28 ribosomal protein L28 -0.0404689
FTH1 ferritin, heavy polypeptide 1 -0.0403809
WDR45B WD repeat domain 45B -0.0393794
H1-0 H1.0 linker histone -0.0391318
RPL8 ribosomal protein L8 -0.0385937
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0385485
AREG amphiregulin -0.0380713
RPL37A ribosomal protein L37a -0.0377876
RPL34 ribosomal protein L34 -0.0377672
HLA-B major histocompatibility complex, class I, B -0.0371658
GARS1 glycyl-tRNA synthetase 1 -0.0369182
LYZ lysozyme -0.0363728
RPL11 ribosomal protein L11 -0.0359613
S100P S100 calcium binding protein P -0.0355204
IFI27 interferon, alpha-inducible protein 27 -0.0346928
RPL26 ribosomal protein L26 -0.0345444
GNAS GNAS complex locus -0.0343925
KRT19 keratin 19, type I -0.0340426
RPS16 ribosomal protein S16 -0.0340347
PFN1 profilin 1 -0.0339003
ACTN4 actinin, alpha 4 -0.0333477
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0333104
RPS11 ribosomal protein S11 -0.0329082
RPS24 ribosomal protein S24 -0.0328894
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0325979
JUP junction plakoglobin -0.0321552
RPS12 ribosomal protein S12 -0.031745
KRT7 keratin 7, type II -0.0312537
FLNB filamin B, beta -0.0312532
VEGFA vascular endothelial growth factor A -0.0311928
MUC1 mucin 1, cell surface associated -0.0311301
RPLP2 ribosomal protein, large, P2 -0.0305244
MUC17 mucin 17, cell surface associated -0.030387
RPL9 ribosomal protein L9 -0.0303832
RPS29 ribosomal protein S29 -0.0302843
CALR calreticulin -0.030188
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0299717
RPS14 ribosomal protein S14 -0.0297542
GSTP1 glutathione S-transferase pi 1 -0.0294906
PDIA3 protein disulfide isomerase family A, member 3 -0.0293698
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0291319
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0287713
RPS17 ribosomal protein S17 -0.0287519
RAB7A RAB7A, member RAS oncogene family -0.0284927
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0282323
RPL36A ribosomal protein L36a -0.0280768
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0279926
RPL18 ribosomal protein L18 -0.0277219
KRT18 keratin 18, type I -0.0274957
WASF2 WAS protein family, member 2 -0.0270988
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0270151
TFF2 trefoil factor 2 -0.0269976
RPS5 ribosomal protein S5 -0.0269803
RPL35 ribosomal protein L35 -0.0267367
CST3 cystatin C -0.0267009
EMP1 epithelial membrane protein 1 -0.0266922
RPL7A ribosomal protein L7a -0.0266439
CLDN4 claudin 4 -0.0264515
RPS27A ribosomal protein S27a -0.02616
KLK10 kallikrein-related peptidase 10 -0.0261471
GOLGA4 golgin A4 -0.0258827
RPL5 ribosomal protein L5 -0.0258799