venetoclax_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description venetoclax perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the venetoclax_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.113606
LMO7 LIM domain 7 0.058304
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0569449
NEBL nebulette 0.0485762
AFF1 AF4/FMR2 family, member 1 0.0288253
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0262276
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.025304
PARD3B par-3 family cell polarity regulator beta 0.0242183
CEMIP2 cell migration inducing hyaluronidase 2 0.0235193
HSPA8 heat shock 70kDa protein 8 0.0230629
EXT1 exostosin glycosyltransferase 1 0.0222879
TGFBR3 transforming growth factor, beta receptor III 0.0212591
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0206424
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0195191
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0194487
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0183136
MBNL1 muscleblind-like splicing regulator 1 0.0181691
PDZD8 PDZ domain containing 8 0.0177128
POF1B premature ovarian failure, 1B 0.0168312
ATXN1 ataxin 1 0.0165734
AKAP13 A kinase (PRKA) anchor protein 13 0.0158819
RIGI RNA sensor RIG-I 0.015539
EREG epiregulin 0.0150594
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0142917
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0140788
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0139791
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.013868
EPS8 epidermal growth factor receptor pathway substrate 8 0.0136276
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0135352
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.013482
DSPP dentin sialophosphoprotein 0.0133342
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0128486
USP9X ubiquitin specific peptidase 9, X-linked 0.0124971
KLF5 Kruppel-like factor 5 (intestinal) 0.0123901
ARHGAP42 Rho GTPase activating protein 42 0.0119323
MUC13 mucin 13, cell surface associated 0.011929
ECT2 epithelial cell transforming 2 0.0119007
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.011773
MARCHF3 membrane associated ring-CH-type finger 3 0.0117177
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0116551
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0116498
UNC13B unc-13 homolog B (C. elegans) 0.011549
PHF3 PHD finger protein 3 0.0114337
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0113444
MYO5B myosin VB 0.0111693
USP6NL USP6 N-terminal like 0.0111173
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0110175
GDA guanine deaminase 0.0109187
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0105955
MED13 mediator complex subunit 13 0.0105083
ERBIN erbb2 interacting protein 0.0104916
ZSWIM6 zinc finger, SWIM-type containing 6 0.010417
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0103498
ZFC3H1 zinc finger, C3H1-type containing 0.0102934
INTS6 integrator complex subunit 6 0.0102932
PDIA4 protein disulfide isomerase family A, member 4 0.00994851
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00994395
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0098462
ADGRV1 adhesion G protein-coupled receptor V1 0.0098227
SHROOM3 shroom family member 3 0.00981584
FOXP1 forkhead box P1 0.00979242
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00966663
NEK7 NIMA-related kinase 7 0.00959986
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.00957436
SGMS2 sphingomyelin synthase 2 0.00956695
ZC3H11A zinc finger CCCH-type containing 11A 0.00956174
USP53 ubiquitin specific peptidase 53 0.0095332
AEBP2 AE binding protein 2 0.00952547
PELI1 pellino E3 ubiquitin protein ligase 1 0.00944489
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0092603
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.00912859
ADARB1 adenosine deaminase, RNA-specific, B1 0.00907365
ANKRD36 ankyrin repeat domain 36 0.00906031
CRY1 cryptochrome circadian clock 1 0.00900391
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.00895626
CXCL8 chemokine (C-X-C motif) ligand 8 0.0089424
JAK2 Janus kinase 2 0.00883145
PRELID2 PRELI domain containing 2 0.00882728
KIAA2026 KIAA2026 0.00878534
ERRFI1 ERBB receptor feedback inhibitor 1 0.00874749
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.00866438
FBXL17 F-box and leucine-rich repeat protein 17 0.0084993
SPRED1 sprouty-related, EVH1 domain containing 1 0.00824725
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.00813184
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.00812705
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.00806456
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.00799016
KIAA1328 KIAA1328 0.00791215
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0078936
GOLGB1 golgin B1 0.00786471
FNDC3B fibronectin type III domain containing 3B 0.00785303
ARHGAP21 Rho GTPase activating protein 21 0.00782292
JMY junction mediating and regulatory protein, p53 cofactor 0.00766165
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.00765116
TOP2B topoisomerase (DNA) II beta 180kDa 0.00761959
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.00758521
FOXP2 forkhead box P2 0.00755178
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 0.00748613
FAM107B family with sequence similarity 107, member B 0.00744145
ASPH aspartate beta-hydroxylase 0.00737726

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.27388
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.203604
TMSB10 thymosin beta 10 -0.198839
RPS6 ribosomal protein S6 -0.178899
TPT1 tumor protein, translationally-controlled 1 -0.149139
RPL35A ribosomal protein L35a -0.126677
RPS8 ribosomal protein S8 -0.12153
MUC6 mucin 6, oligomeric mucus/gel-forming -0.119085
RPS12 ribosomal protein S12 -0.0983161
NPSR1 neuropeptide S receptor 1 -0.0965321
RPL37A ribosomal protein L37a -0.0931493
RPS19 ribosomal protein S19 -0.0871603
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0834974
FTL ferritin, light polypeptide -0.0822837
RPL23 ribosomal protein L23 -0.0819436
RPLP2 ribosomal protein, large, P2 -0.0817922
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0807539
RPLP1 ribosomal protein, large, P1 -0.0766726
RPL34 ribosomal protein L34 -0.0753787
RPL9 ribosomal protein L9 -0.0749932
ACTG1 actin gamma 1 -0.0744837
ANXA2 annexin A2 -0.0738449
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0732094
RPS3 ribosomal protein S3 -0.072632
RPL26 ribosomal protein L26 -0.0713698
RPL31 ribosomal protein L31 -0.0683963
FLNB filamin B, beta -0.067717
NDRG1 N-myc downstream regulated 1 -0.0665584
RPL36 ribosomal protein L36 -0.0659062
RPL12 ribosomal protein L12 -0.0655076
S100A6 S100 calcium binding protein A6 -0.0644287
RPL11 ribosomal protein L11 -0.0628837
RPS27A ribosomal protein S27a -0.0628257
RPS25 ribosomal protein S25 -0.0598196
RPS13 ribosomal protein S13 -0.0596198
NALF1 NALCN channel auxiliary factor 1 -0.0594958
RPS24 ribosomal protein S24 -0.0581345
RPL5 ribosomal protein L5 -0.0568149
PKM pyruvate kinase, muscle -0.0524717
RPS29 ribosomal protein S29 -0.0522383
ONECUT3 one cut homeobox 3 -0.0511331
S100A9 S100 calcium binding protein A9 -0.0504355
RPS21 ribosomal protein S21 -0.0504302
RPL19 ribosomal protein L19 -0.0502
RPS23 ribosomal protein S23 -0.0500942
HMGA1 high mobility group AT-hook 1 -0.0500413
ACTN4 actinin, alpha 4 -0.0500406
EEF2 eukaryotic translation elongation factor 2 -0.049776
B2M beta-2-microglobulin -0.0476445
RPS27 ribosomal protein S27 -0.0475724
RPL13A ribosomal protein L13a -0.0473615
RPL7A ribosomal protein L7a -0.0467915
KRT18 keratin 18, type I -0.0464075
RPLP0 ribosomal protein, large, P0 -0.0463542
TPM4 tropomyosin 4 -0.0457029
RPS17 ribosomal protein S17 -0.0453647
PGK1 phosphoglycerate kinase 1 -0.0453262
TNS4 tensin 4 -0.0452425
ITGA6 integrin, alpha 6 -0.0451615
RPL37 ribosomal protein L37 -0.0449811
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0443646
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0424345
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0423561
RPS14 ribosomal protein S14 -0.0414797
RPL8 ribosomal protein L8 -0.041376
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0410652
RPS16 ribosomal protein S16 -0.0401092
RPL28 ribosomal protein L28 -0.0393109
EIF1 eukaryotic translation initiation factor 1 -0.0391401
LOC112694756 uncharaterized LOC112694756 -0.038258
S100P S100 calcium binding protein P -0.0380365
POTEF POTE ankyrin domain family, member F -0.0379796
GREB1L growth regulation by estrogen in breast cancer-like -0.0370609
GOLGA4 golgin A4 -0.0369215
FRMD5 FERM domain containing 5 -0.0361067
RACK1 receptor for activated C kinase 1 -0.0359803
SOX4 SRY (sex determining region Y)-box 4 -0.0355392
RPL27A ribosomal protein L27a -0.0354443
RPL36A ribosomal protein L36a -0.0350809
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0350688
RPS11 ribosomal protein S11 -0.0348476
TFF3 trefoil factor 3 (intestinal) -0.0348168
EIF5B eukaryotic translation initiation factor 5B -0.0345716
KRT19 keratin 19, type I -0.0341044
ISG15 ISG15 ubiquitin-like modifier -0.0338914
ENO1 enolase 1, (alpha) -0.033686
CALB1 calbindin 1, 28kDa -0.033544
MT2A metallothionein 2A -0.0334785
ITGB4 integrin, beta 4 -0.0332568
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0329242
KRT8 keratin 8, type II -0.0326563
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0325603
RPS20 ribosomal protein S20 -0.0324629
AHNAK AHNAK nucleoprotein -0.0320703
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0320566
RPL35 ribosomal protein L35 -0.0320029
RPL18 ribosomal protein L18 -0.0318373
RPS10 ribosomal protein S10 -0.0318079
VCL vinculin -0.031781
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0314066