| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | venetoclax perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the venetoclax_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DST | dystonin | 0.232062 |
| TP63 | tumor protein p63 | 0.121201 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.111578 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0874095 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0851393 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0826751 |
| HDAC9 | histone deacetylase 9 | 0.0796192 |
| SP100 | SP100 nuclear antigen | 0.0716669 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0657588 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0613247 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0601962 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0588073 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0568759 |
| SPAG9 | sperm associated antigen 9 | 0.0517821 |
| PRELID2 | PRELI domain containing 2 | 0.0511756 |
| EPHA4 | EPH receptor A4 | 0.0489295 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0481244 |
| PLK2 | polo-like kinase 2 | 0.0473095 |
| EREG | epiregulin | 0.0459821 |
| ENO1 | enolase 1, (alpha) | 0.0440138 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0433797 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0433405 |
| PLSCR1 | phospholipid scramblase 1 | 0.042081 |
| INTS6 | integrator complex subunit 6 | 0.0407153 |
| MYOF | myoferlin | 0.0406884 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0406604 |
| SQSTM1 | sequestosome 1 | 0.0401716 |
| SDC4 | syndecan 4 | 0.0382094 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0381256 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.036862 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0366821 |
| LDHA | lactate dehydrogenase A | 0.0364345 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0363456 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0358352 |
| GOLGB1 | golgin B1 | 0.0357771 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0357345 |
| RNF213 | ring finger protein 213 | 0.0354357 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0344897 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0326933 |
| MB21D2 | Mab-21 domain containing 2 | 0.0321881 |
| MT1E | metallothionein 1E | 0.0314323 |
| RIGI | RNA sensor RIG-I | 0.031225 |
| CADM2 | cell adhesion molecule 2 | 0.0308022 |
| B2M | beta-2-microglobulin | 0.0302571 |
| RAD51B | RAD51 paralog B | 0.0297595 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0296525 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0293311 |
| TNS3 | tensin 3 | 0.0289333 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0286748 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0284227 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0277702 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0273781 |
| HLA-E | major histocompatibility complex, class I, E | 0.027301 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0272789 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0272786 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0271618 |
| ASPH | aspartate beta-hydroxylase | 0.027143 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0270737 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0270167 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0267717 |
| SMYD3 | SET and MYND domain containing 3 | 0.02647 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0264242 |
| HOMER1 | homer scaffolding protein 1 | 0.0263149 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0262695 |
| CANX | calnexin | 0.026246 |
| RUNX1 | runt-related transcription factor 1 | 0.0262061 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0260175 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0258282 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0255532 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0251977 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0250891 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0249812 |
| RPS12 | ribosomal protein S12 | 0.0249195 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0246285 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0245539 |
| LYST | lysosomal trafficking regulator | 0.0242693 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0242421 |
| FNIP1 | folliculin interacting protein 1 | 0.0241915 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0240468 |
| SVIL | supervillin | 0.0234128 |
| EGFR | epidermal growth factor receptor | 0.0232714 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0229928 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.0228548 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0228449 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0228145 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0226106 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0225448 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0223424 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0222502 |
| ZNF638 | zinc finger protein 638 | 0.0220506 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0220357 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0219566 |
| AEBP2 | AE binding protein 2 | 0.0216607 |
| VCL | vinculin | 0.0212753 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0211272 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.02074 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0205673 |
| TRIM56 | tripartite motif containing 56 | 0.020373 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0200883 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0200659 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.243183 |
| VIM | vimentin | -0.151987 |
| POTEF | POTE ankyrin domain family, member F | -0.118215 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.111013 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0963466 |
| TXNRD1 | thioredoxin reductase 1 | -0.0960468 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0928211 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0905191 |
| TMSB10 | thymosin beta 10 | -0.087637 |
| HMGA1 | high mobility group AT-hook 1 | -0.0771145 |
| EGR1 | early growth response 1 | -0.0752959 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0741629 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0739572 |
| RAI1 | retinoic acid induced 1 | -0.0710135 |
| ACTG1 | actin gamma 1 | -0.0701445 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0638544 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0629245 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0571088 |
| RTN4 | reticulon 4 | -0.0558893 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0512071 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0508455 |
| CENPF | centromere protein F, 350/400kDa | -0.0505192 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.049255 |
| FLNB | filamin B, beta | -0.047555 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0454645 |
| TMEM41B | transmembrane protein 41B | -0.0444973 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0444281 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0416237 |
| APP | amyloid beta (A4) precursor protein | -0.0404468 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0403646 |
| FOSL1 | FOS-like antigen 1 | -0.0388157 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0384765 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.038287 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0382179 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0373788 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.036012 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0355702 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0355643 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0355187 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0351886 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.034759 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0342243 |
| PYGB | phosphorylase, glycogen; brain | -0.0338762 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0338199 |
| FMNL2 | formin-like 2 | -0.0337723 |
| RPL35A | ribosomal protein L35a | -0.0337043 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0333597 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0331384 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | -0.0325511 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0325386 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.032357 |
| WASF2 | WAS protein family, member 2 | -0.0320677 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0320474 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0318234 |
| RBM25 | RNA binding motif protein 25 | -0.0317342 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0315976 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0314105 |
| BRD4 | bromodomain containing 4 | -0.0310509 |
| FBXO11 | F-box protein 11 | -0.0306464 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0298399 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.029805 |
| TOP1 | topoisomerase (DNA) I | -0.0297136 |
| SRPK2 | SRSF protein kinase 2 | -0.0295666 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0292795 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.028663 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0286114 |
| MKI67 | marker of proliferation Ki-67 | -0.0285655 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.027946 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0275758 |
| TPM4 | tropomyosin 4 | -0.0271248 |
| RAP2B | RAP2B, member of RAS oncogene family | -0.0267976 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0267513 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0266116 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0264991 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0261669 |
| EZR | ezrin | -0.0261292 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0261205 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0260607 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0259232 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0258287 |
| MAP4 | microtubule-associated protein 4 | -0.0258261 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0256176 |
| TUBB6 | tubulin, beta 6 class V | -0.0252888 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0252468 |
| ITGB4 | integrin, beta 4 | -0.0252347 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0251583 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0247151 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0245776 |
| CCNL1 | cyclin L1 | -0.0245368 |
| PFN1 | profilin 1 | -0.0245207 |
| PKM | pyruvate kinase, muscle | -0.0241218 |
| ATN1 | atrophin 1 | -0.0239937 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0239681 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0239264 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0238618 |
| TAPBP | TAP binding protein (tapasin) | -0.0237881 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.02362 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0235067 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0233701 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0232777 |
