venetoclax_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description venetoclax perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the venetoclax_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.346599
ASPH aspartate beta-hydroxylase 0.15941
CXCL8 chemokine (C-X-C motif) ligand 8 0.149854
THSD4 thrombospondin, type I, domain containing 4 0.115437
SLTM SAFB-like, transcription modulator 0.109507
PDE4D phosphodiesterase 4D, cAMP-specific 0.100636
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0817399
PTPRM protein tyrosine phosphatase, receptor type, M 0.0790659
FNDC3B fibronectin type III domain containing 3B 0.0783485
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0694149
LMO7 LIM domain 7 0.0692541
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0690572
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0667201
EFNA5 ephrin-A5 0.0633589
MYOF myoferlin 0.0592346
GRAMD1B GRAM domain containing 1B 0.0592091
LDHA lactate dehydrogenase A 0.0520909
ERRFI1 ERBB receptor feedback inhibitor 1 0.0516278
MCTP1 multiple C2 domains, transmembrane 1 0.0482507
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0481728
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0481506
CAV1 caveolin 1, caveolae protein, 22kDa 0.0478432
PDLIM5 PDZ and LIM domain 5 0.0462003
MT2A metallothionein 2A 0.0460823
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0455771
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0450082
MYO1E myosin IE 0.043692
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0414125
RNF213 ring finger protein 213 0.0397994
INTS6 integrator complex subunit 6 0.0396806
RAD51B RAD51 paralog B 0.0394561
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0392261
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.038251
LPP LIM domain containing preferred translocation partner in lipoma 0.0381454
NPAS2 neuronal PAS domain protein 2 0.0371129
PM20D1 peptidase M20 domain containing 1 0.0366381
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0363251
CEMIP cell migration inducing protein, hyaluronan binding 0.0357928
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0355064
SMAD3 SMAD family member 3 0.0350432
ZSWIM6 zinc finger, SWIM-type containing 6 0.0343476
FAM13A family with sequence similarity 13, member A 0.033348
BCAR3 breast cancer anti-estrogen resistance 3 0.0330499
SMYD3 SET and MYND domain containing 3 0.0327526
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0326305
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0321978
EXT1 exostosin glycosyltransferase 1 0.03209
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0316867
SCEL sciellin 0.0309436
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.030917
DOCK5 dedicator of cytokinesis 5 0.0304409
BZW1 basic leucine zipper and W2 domains 1 0.0303534
CPE carboxypeptidase E 0.0302268
AKAP12 A kinase (PRKA) anchor protein 12 0.0295978
AKAP13 A kinase (PRKA) anchor protein 13 0.0292009
HSPA8 heat shock 70kDa protein 8 0.0291106
DSPP dentin sialophosphoprotein 0.0290012
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0288611
SP100 SP100 nuclear antigen 0.0288285
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.028796
FOXP1 forkhead box P1 0.0287066
SVIL supervillin 0.0284295
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0281733
MACF1 microtubule-actin crosslinking factor 1 0.0281293
ENO1 enolase 1, (alpha) 0.0275183
CCSER1 coiled-coil serine-rich protein 1 0.0275151
LGALS12 lectin, galactoside-binding, soluble, 12 0.0272087
GRB10 growth factor receptor-bound protein 10 0.0270514
PARP14 poly (ADP-ribose) polymerase family, member 14 0.026995
GPHN gephyrin 0.0269001
HOMER1 homer scaffolding protein 1 0.0258276
VEGFC vascular endothelial growth factor C 0.0257804
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0253946
KYNU kynureninase 0.0252885
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0250988
PTK2 protein tyrosine kinase 2 0.0250598
PYGL phosphorylase, glycogen, liver 0.0249595
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0248678
AREG amphiregulin 0.0247839
LRP1B low density lipoprotein receptor-related protein 1B 0.0246529
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0245407
ELL2 elongation factor, RNA polymerase II, 2 0.0244624
DOCK1 dedicator of cytokinesis 1 0.0238931
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0238441
MBNL1 muscleblind-like splicing regulator 1 0.023752
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0236944
BIRC3 baculoviral IAP repeat containing 3 0.0236764
SLK STE20-like kinase 0.0234059
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0232954
SAMD4A sterile alpha motif domain containing 4A 0.0232812
SUMF1 sulfatase modifying factor 1 0.0231755
MAP7 microtubule-associated protein 7 0.0231481
TES testin LIM domain protein 0.0231085
FNDC3A fibronectin type III domain containing 3A 0.0230188
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0229226
TBC1D22A TBC1 domain family, member 22A 0.0228745
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0227088
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0224149
ZNF638 zinc finger protein 638 0.0223916
S100A10 S100 calcium binding protein A10 0.0221926

decreased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0979575
UBC ubiquitin C -0.0826353
FTL ferritin, light polypeptide -0.0723621
PTMA prothymosin, alpha -0.0643927
RPS3 ribosomal protein S3 -0.0559566
NDRG1 N-myc downstream regulated 1 -0.0531451
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0491808
RPS27A ribosomal protein S27a -0.0489527
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0464717
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0415136
FTH1 ferritin, heavy polypeptide 1 -0.0395218
RPL37A ribosomal protein L37a -0.0394978
TPT1 tumor protein, translationally-controlled 1 -0.0362953
H1-0 H1.0 linker histone -0.0360088
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0347119
RPS12 ribosomal protein S12 -0.0333185
TMEM165 transmembrane protein 165 -0.0322914
NAMPT nicotinamide phosphoribosyltransferase -0.0310985
P4HB prolyl 4-hydroxylase, beta polypeptide -0.030748
RPL35A ribosomal protein L35a -0.0304851
WDR45B WD repeat domain 45B -0.0296724
EEF2 eukaryotic translation elongation factor 2 -0.0293632
RPS25 ribosomal protein S25 -0.0279107
OGA O-GlcNAcase -0.027562
CAMTA1 calmodulin binding transcription activator 1 -0.0270007
RPS8 ribosomal protein S8 -0.0268615
NGLY1 N-glycanase 1 -0.0266445
RPL31 ribosomal protein L31 -0.026224
BRWD1 bromodomain and WD repeat domain containing 1 -0.0261226
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0256917
WASF2 WAS protein family, member 2 -0.0253839
WSB1 WD repeat and SOCS box containing 1 -0.0252788
CES1 carboxylesterase 1 -0.024798
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0233983
SEC61G Sec61 gamma subunit -0.0226526
EIF1 eukaryotic translation initiation factor 1 -0.0225187
TMSB10 thymosin beta 10 -0.0210072
AHNAK AHNAK nucleoprotein -0.0200709
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0197162
B2M beta-2-microglobulin -0.0194319
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.019364
RPL34 ribosomal protein L34 -0.0189609
RAP1B RAP1B, member of RAS oncogene family -0.0188786
RPS17 ribosomal protein S17 -0.018804
PCBP2 poly(rC) binding protein 2 -0.0185903
RPS24 ribosomal protein S24 -0.0184716
PLEC plectin -0.0182221
RPL9 ribosomal protein L9 -0.0182175
RTN4 reticulon 4 -0.0178433
LOC112694756 uncharaterized LOC112694756 -0.0178298
AKR1C1 aldo-keto reductase family 1, member C1 -0.0176051
KCMF1 potassium channel modulatory factor 1 -0.0171977
RPS27 ribosomal protein S27 -0.0170956
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.017067
FAM162A family with sequence similarity 162, member A -0.0168721
CCNI cyclin I -0.016651
KDM5B lysine (K)-specific demethylase 5B -0.0164781
ANKRD10 ankyrin repeat domain 10 -0.0162518
RPL12 ribosomal protein L12 -0.0162043
ZFC3H1 zinc finger, C3H1-type containing -0.0161938
RPS29 ribosomal protein S29 -0.0161385
PRRC2C proline-rich coiled-coil 2C -0.01603
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0156888
HOOK2 hook microtubule-tethering protein 2 -0.0156677
CANX calnexin -0.0156443
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0153927
HYOU1 hypoxia up-regulated 1 -0.0151876
LAMB3 laminin, beta 3 -0.0149632
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.014917
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0149125
SREBF2 sterol regulatory element binding transcription factor 2 -0.0148437
RPL26 ribosomal protein L26 -0.0147838
RPLP2 ribosomal protein, large, P2 -0.0147253
RPL23 ribosomal protein L23 -0.0147126
RPS6 ribosomal protein S6 -0.014556
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0144981
RPL36 ribosomal protein L36 -0.0143735
KDM3A lysine (K)-specific demethylase 3A -0.0142907
EP300 E1A binding protein p300 -0.0141582
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0140699
KMT2A lysine (K)-specific methyltransferase 2A -0.0139975
ADAM17 ADAM metallopeptidase domain 17 -0.0139447
RAB1A RAB1A, member RAS oncogene family -0.0138346
BRWD3 bromodomain and WD repeat domain containing 3 -0.0138016
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0136611
LAMC2 laminin, gamma 2 -0.0135502
NDE1 nudE neurodevelopment protein 1 -0.0133013
HDLBP high density lipoprotein binding protein -0.0133
RPS21 ribosomal protein S21 -0.013201
NPC1 Niemann-Pick disease, type C1 -0.0130574
RPL11 ribosomal protein L11 -0.0129401
RPL13A ribosomal protein L13a -0.0128706
MARF1 meiosis regulator and mRNA stability factor 1 -0.0128032
SRP54 signal recognition particle 54kDa -0.0127178
UBE2B ubiquitin-conjugating enzyme E2B -0.012631
RPL36A ribosomal protein L36a -0.0125957
RPS19 ribosomal protein S19 -0.0125483
RPLP1 ribosomal protein, large, P1 -0.0125218
CTTN cortactin -0.0123958
MGAT4C MGAT4 family, member C -0.0123624