venetoclax_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description venetoclax perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the venetoclax_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.15415
PDE4D phosphodiesterase 4D, cAMP-specific 0.123735
PM20D1 peptidase M20 domain containing 1 0.0884768
FNDC3B fibronectin type III domain containing 3B 0.085247
SMOC1 SPARC related modular calcium binding 1 0.07978
ZSWIM6 zinc finger, SWIM-type containing 6 0.077358
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0760729
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0715952
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0600212
CXCL8 chemokine (C-X-C motif) ligand 8 0.0545634
GLS2 glutaminase 2 (liver, mitochondrial) 0.0541086
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0527881
SOD2 superoxide dismutase 2, mitochondrial 0.0526747
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0526305
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0504012
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0499778
ELL2 elongation factor, RNA polymerase II, 2 0.0487956
WAC WW domain containing adaptor with coiled-coil 0.0479975
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0447206
ARHGAP26 Rho GTPase activating protein 26 0.0434016
RICTOR RPTOR independent companion of MTOR, complex 2 0.04288
ZFAND3 zinc finger, AN1-type domain 3 0.038866
KTN1 kinectin 1 (kinesin receptor) 0.0378563
SAMD4A sterile alpha motif domain containing 4A 0.036581
FAM107B family with sequence similarity 107, member B 0.0349645
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.033496
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0334467
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0330623
MYOF myoferlin 0.0326592
FGA fibrinogen alpha chain 0.032163
ATXN1 ataxin 1 0.0320535
DSCAM Down syndrome cell adhesion molecule 0.0319096
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0314605
RB1CC1 RB1-inducible coiled-coil 1 0.0313773
GOLGB1 golgin B1 0.0312899
FBXL20 F-box and leucine-rich repeat protein 20 0.0307276
SFPQ splicing factor proline/glutamine-rich 0.0306082
NEK7 NIMA-related kinase 7 0.0305817
MYO1E myosin IE 0.02985
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0286094
HELZ helicase with zinc finger 0.0285303
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0281861
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0278383
APLP2 amyloid beta (A4) precursor-like protein 2 0.0276136
SIK3 SIK family kinase 3 0.0272251
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0268329
AKAP13 A kinase (PRKA) anchor protein 13 0.0267107
NCOA2 nuclear receptor coactivator 2 0.0262497
CHD1 chromodomain helicase DNA binding protein 1 0.0262047
LPP LIM domain containing preferred translocation partner in lipoma 0.0261697
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0259307
MACF1 microtubule-actin crosslinking factor 1 0.0254864
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0254185
KIF5B kinesin family member 5B 0.0251133
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0249021
AKAP9 A kinase (PRKA) anchor protein 9 0.0248504
KYNU kynureninase 0.0248086
INTS6 integrator complex subunit 6 0.024685
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0240762
FOXO3 forkhead box O3 0.0240641
CUL3 cullin 3 0.0238567
EXT1 exostosin glycosyltransferase 1 0.0238545
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0236654
YAP1 Yes-associated protein 1 0.0235111
BMP6 bone morphogenetic protein 6 0.0233602
TENT5A terminal nucleotidyltransferase 5A 0.0230319
TRA2A transformer 2 alpha homolog (Drosophila) 0.022909
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0228473
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0226892
KIAA0319 KIAA0319 0.022632
CCPG1 cell cycle progression 1 0.0226154
WWOX WW domain containing oxidoreductase 0.0225666
PDE10A phosphodiesterase 10A 0.0225652
PHF3 PHD finger protein 3 0.0222129
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0217259
TPM3 tropomyosin 3 0.0216624
FTH1 ferritin, heavy polypeptide 1 0.0212473
MED13 mediator complex subunit 13 0.021129
SPAG9 sperm associated antigen 9 0.020616
UBASH3B ubiquitin associated and SH3 domain containing B 0.020477
EPAS1 endothelial PAS domain protein 1 0.0203424
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0203387
BBX bobby sox homolog (Drosophila) 0.0202935
ATF6 activating transcription factor 6 0.0202577
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0200686
NIPBL Nipped-B homolog (Drosophila) 0.0200453
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0198961
SLMAP sarcolemma associated protein 0.0197766
PHIP pleckstrin homology domain interacting protein 0.0197617
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0197487
CSNK1A1 casein kinase 1, alpha 1 0.0196058
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0193634
CCL5 chemokine (C-C motif) ligand 5 0.019071
PTGES2 prostaglandin E synthase 2 0.0190115
KIF13A kinesin family member 13A 0.0189377
SEC31A SEC31 homolog A (S. cerevisiae) 0.0189152
NUP98 nucleoporin 98kDa 0.0189003
COPA coatomer protein complex, subunit alpha 0.0186737
LOC102724023 ES1 protein homolog, mitochondrial 0.0186252
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0185678

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.182502
TXNRD1 thioredoxin reductase 1 -0.17939
GRAMD1B GRAM domain containing 1B -0.162143
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.13772
IGF2 insulin-like growth factor 2 -0.137038
ACTG1 actin gamma 1 -0.122502
FTL ferritin, light polypeptide -0.11957
VIM vimentin -0.118677
PTMA prothymosin, alpha -0.0892369
THSD4 thrombospondin, type I, domain containing 4 -0.0833165
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0757461
TM4SF1 transmembrane 4 L six family member 1 -0.0749797
RPS21 ribosomal protein S21 -0.0656311
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0654148
RPL19 ribosomal protein L19 -0.0652787
TFPI2 tissue factor pathway inhibitor 2 -0.0644709
RPL35A ribosomal protein L35a -0.0630143
RPL23 ribosomal protein L23 -0.0629523
HDAC9 histone deacetylase 9 -0.06127
TMSB10 thymosin beta 10 -0.0610402
RPL37A ribosomal protein L37a -0.0603456
BICC1 BicC family RNA binding protein 1 -0.0574978
RPS27A ribosomal protein S27a -0.0556345
CMIP c-Maf inducing protein -0.0553638
RPL36 ribosomal protein L36 -0.0551529
NRG1 neuregulin 1 -0.053936
RPS12 ribosomal protein S12 -0.0533386
RPS8 ribosomal protein S8 -0.0521258
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0509275
SLC38A2 solute carrier family 38, member 2 -0.0494455
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0493574
RPS19 ribosomal protein S19 -0.047618
RPS3 ribosomal protein S3 -0.0472523
RPS29 ribosomal protein S29 -0.0469903
RPL31 ribosomal protein L31 -0.0457917
PKM pyruvate kinase, muscle -0.0438517
AK1 adenylate kinase 1 -0.0436023
PFDN2 prefoldin subunit 2 -0.043343
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0419336
RPS25 ribosomal protein S25 -0.0412733
KPNB1 karyopherin (importin) beta 1 -0.0411497
RPL26 ribosomal protein L26 -0.0406897
EGR1 early growth response 1 -0.0400225
TPM4 tropomyosin 4 -0.0383472
EEF2 eukaryotic translation elongation factor 2 -0.0382961
HMGA1 high mobility group AT-hook 1 -0.0380801
RPLP1 ribosomal protein, large, P1 -0.0368164
IGFBP4 insulin-like growth factor binding protein 4 -0.036618
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0361198
RPL13A ribosomal protein L13a -0.035664
RPS6 ribosomal protein S6 -0.0352143
TPT1 tumor protein, translationally-controlled 1 -0.0342621
EIF1 eukaryotic translation initiation factor 1 -0.0340218
VDAC1 voltage-dependent anion channel 1 -0.0339635
RSL1D1 ribosomal L1 domain containing 1 -0.0339353
RACK1 receptor for activated C kinase 1 -0.0337874
ACACA acetyl-CoA carboxylase alpha -0.0334831
RPL5 ribosomal protein L5 -0.0334528
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0333572
IER3 immediate early response 3 -0.0332263
RPS17 ribosomal protein S17 -0.0331488
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0328583
MAML3 mastermind-like 3 (Drosophila) -0.0328464
RPS24 ribosomal protein S24 -0.0328394
OSMR oncostatin M receptor -0.0323031
RPL11 ribosomal protein L11 -0.0319939
MAP1B microtubule-associated protein 1B -0.031628
THBS1 thrombospondin 1 -0.0315944
RPL34 ribosomal protein L34 -0.0302825
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0299396
RPLP2 ribosomal protein, large, P2 -0.0298065
RPL37 ribosomal protein L37 -0.0297699
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0294731
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0293265
RPL9 ribosomal protein L9 -0.0292598
GARS1 glycyl-tRNA synthetase 1 -0.0291818
SERF2 small EDRK-rich factor 2 -0.0290854
NAV3 neuron navigator 3 -0.0289047
RPS16 ribosomal protein S16 -0.0288683
RPL12 ribosomal protein L12 -0.0284407
EIF5B eukaryotic translation initiation factor 5B -0.0283291
RCC1 regulator of chromosome condensation 1 -0.0277248
CAVIN1 caveolae associated protein 1 -0.0273285
AHNAK AHNAK nucleoprotein -0.0268566
RPL8 ribosomal protein L8 -0.0267335
RPS13 ribosomal protein S13 -0.0266398
PA2G4 proliferation-associated 2G4, 38kDa -0.0266364
RPS23 ribosomal protein S23 -0.0262033
RPS10 ribosomal protein S10 -0.0261062
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.025985
ATP5F1B ATP synthase F1 subunit beta -0.0259553
RTN4 reticulon 4 -0.025913
DGKD diacylglycerol kinase, delta 130kDa -0.0258038
BABAM2 BRISC and BRCA1 A complex member 2 -0.025791
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0251488
RPL7 ribosomal protein L7 -0.0251214
RPL38 ribosomal protein L38 -0.0247123
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0245913
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0243257
RPS14 ribosomal protein S14 -0.0242933