venetoclax_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description venetoclax perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the venetoclax_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.198769
TXNRD1 thioredoxin reductase 1 0.109959
TFPI2 tissue factor pathway inhibitor 2 0.0828997
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0651994
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.060209
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0590484
SYNE2 spectrin repeat containing, nuclear envelope 2 0.055776
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0524506
ZSWIM6 zinc finger, SWIM-type containing 6 0.0521232
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0499639
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0481585
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0471286
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0462284
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0450899
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0438917
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0401769
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0395907
NIPBL Nipped-B homolog (Drosophila) 0.0391812
YAP1 Yes-associated protein 1 0.0386072
SNAP25 synaptosomal-associated protein, 25kDa 0.0384747
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0378801
XPO1 exportin 1 0.0373994
PDE4D phosphodiesterase 4D, cAMP-specific 0.0371796
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0371191
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0352607
ZFAND3 zinc finger, AN1-type domain 3 0.0348806
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0331143
HSPA8 heat shock 70kDa protein 8 0.0330872
RNF145 ring finger protein 145 0.0330007
GRAMD1B GRAM domain containing 1B 0.0328308
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0326
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0322934
CSDE1 cold shock domain containing E1, RNA-binding 0.0317391
IPO7 importin 7 0.0303539
ELL2 elongation factor, RNA polymerase II, 2 0.0302098
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0294003
PHF3 PHD finger protein 3 0.0291279
ETNK1 ethanolamine kinase 1 0.0290412
SFPQ splicing factor proline/glutamine-rich 0.0288153
NFE2L2 nuclear factor, erythroid 2-like 2 0.0284827
PLCB4 phospholipase C, beta 4 0.0277606
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0271106
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.026892
DSCAM Down syndrome cell adhesion molecule 0.0263437
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0260217
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0258282
WNK1 WNK lysine deficient protein kinase 1 0.0255703
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0251876
PUM1 pumilio RNA-binding family member 1 0.0251184
BMP5 bone morphogenetic protein 5 0.0244366
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0243754
OGA O-GlcNAcase 0.0243111
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0240258
VCL vinculin 0.0236731
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0233113
TRIO trio Rho guanine nucleotide exchange factor 0.0230874
STAG2 stromal antigen 2 0.0222604
CLTC clathrin, heavy chain (Hc) 0.0221367
CHD1 chromodomain helicase DNA binding protein 1 0.0221333
BIRC2 baculoviral IAP repeat containing 2 0.0220404
USP9X ubiquitin specific peptidase 9, X-linked 0.0219976
NAP1L1 nucleosome assembly protein 1-like 1 0.0214988
NCAPG2 non-SMC condensin II complex, subunit G2 0.021422
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0212759
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.020996
ERBIN erbb2 interacting protein 0.0208936
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0208865
EXOC6B exocyst complex component 6B 0.0208155
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0205679
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0205267
PHIP pleckstrin homology domain interacting protein 0.0203337
MED13L mediator complex subunit 13-like 0.0202057
TPX2 TPX2, microtubule-associated 0.0201932
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0201143
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0200561
AFG2A AFG2 AAA ATPase homolog A 0.0197228
TMPO thymopoietin 0.0197049
CUL3 cullin 3 0.0196367
MSH6 mutS homolog 6 0.0196332
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0194726
RAD21 RAD21 homolog (S. pombe) 0.0194628
MARCHF4 membrane associated ring-CH-type finger 4 0.0194317
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0192305
BIRC3 baculoviral IAP repeat containing 3 0.0192269
WWOX WW domain containing oxidoreductase 0.0192059
DST dystonin 0.0191429
NCKAP1 NCK-associated protein 1 0.0189154
ENO1 enolase 1, (alpha) 0.0188814
NUP153 nucleoporin 153kDa 0.0187729
SPIDR scaffolding protein involved in DNA repair 0.0186543
FXR1 fragile X mental retardation, autosomal homolog 1 0.0186422
CKAP5 cytoskeleton associated protein 5 0.0185687
CPNE1 copine I 0.018392
PUM2 pumilio RNA-binding family member 2 0.0182669
INTS6 integrator complex subunit 6 0.0181466
STK4 serine/threonine kinase 4 0.0180613
UTRN utrophin 0.0178788
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0178561
ATAD2 ATPase family, AAA domain containing 2 0.0178556
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.017766

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.309937
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.229904
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.10877
EGR1 early growth response 1 -0.102075
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0814846
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0795747
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0757108
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0749507
PTMA prothymosin, alpha -0.0712732
TMSB10 thymosin beta 10 -0.0651493
AFF3 AF4/FMR2 family, member 3 -0.0608812
MCL1 myeloid cell leukemia 1 -0.0597082
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0584933
HLA-B major histocompatibility complex, class I, B -0.0578101
RPL35A ribosomal protein L35a -0.0535076
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0528616
RPL37A ribosomal protein L37a -0.0526221
HMGA2 high mobility group AT-hook 2 -0.0502751
VIM vimentin -0.0500818
EGFR epidermal growth factor receptor -0.048068
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0476734
THSD4 thrombospondin, type I, domain containing 4 -0.0471164
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0465408
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0450451
RPS3 ribosomal protein S3 -0.0443432
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0441877
ACTG1 actin gamma 1 -0.0434689
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0414798
RYR3 ryanodine receptor 3 -0.0395256
POTEF POTE ankyrin domain family, member F -0.0387096
IGF2 insulin-like growth factor 2 -0.0376209
TPM2 tropomyosin 2 (beta) -0.0369967
MARCKS myristoylated alanine-rich protein kinase C substrate -0.035978
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0358952
RAB7A RAB7A, member RAS oncogene family -0.0347046
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0341882
EPAS1 endothelial PAS domain protein 1 -0.033857
COPA coatomer protein complex, subunit alpha -0.0336799
ACTN1 actinin, alpha 1 -0.0328754
MT2A metallothionein 2A -0.032702
ATXN1 ataxin 1 -0.0323731
RPS19 ribosomal protein S19 -0.0316732
RPL37 ribosomal protein L37 -0.0311905
RPS21 ribosomal protein S21 -0.0308944
SOS2 son of sevenless homolog 2 (Drosophila) -0.0303445
RPL36 ribosomal protein L36 -0.0298563
FTH1 ferritin, heavy polypeptide 1 -0.0297677
CDCP1 CUB domain containing protein 1 -0.0296263
MAP4 microtubule-associated protein 4 -0.0293032
STC1 stanniocalcin 1 -0.02882
ANKRD12 ankyrin repeat domain 12 -0.0288168
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0286867
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.0283244
PKM pyruvate kinase, muscle -0.0280352
PFN1 profilin 1 -0.0275963
RPS12 ribosomal protein S12 -0.0275465
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0274836
RPS27A ribosomal protein S27a -0.0274122
TM4SF1 transmembrane 4 L six family member 1 -0.0272786
OSMR oncostatin M receptor -0.0272218
PYGL phosphorylase, glycogen, liver -0.027001
WSB1 WD repeat and SOCS box containing 1 -0.0267721
RPL26 ribosomal protein L26 -0.0267151
RPL31 ribosomal protein L31 -0.0266238
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0265985
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0264401
LOXL2 lysyl oxidase-like 2 -0.0263756
ICAM1 intercellular adhesion molecule 1 -0.0261256
RPS8 ribosomal protein S8 -0.0261155
FMNL2 formin-like 2 -0.0261
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0253811
KPNB1 karyopherin (importin) beta 1 -0.0253248
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0252024
SNX9 sorting nexin 9 -0.0250217
CUX1 cut-like homeobox 1 -0.0249683
NDRG1 N-myc downstream regulated 1 -0.024508
RPLP2 ribosomal protein, large, P2 -0.0244016
RSF1 remodeling and spacing factor 1 -0.0242292
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0240564
NTSR1 neurotensin receptor 1 (high affinity) -0.0240474
RPL11 ribosomal protein L11 -0.0237786
WASF2 WAS protein family, member 2 -0.023754
RPS29 ribosomal protein S29 -0.0235461
S100A11 S100 calcium binding protein A11 -0.0230331
TPM4 tropomyosin 4 -0.0229245
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0228752
RPLP1 ribosomal protein, large, P1 -0.0227202
DOCK5 dedicator of cytokinesis 5 -0.0226457
HM13 histocompatibility (minor) 13 -0.0224779
FLNA filamin A, alpha -0.0224169
RPS10 ribosomal protein S10 -0.0222421
KDM2A lysine (K)-specific demethylase 2A -0.0220783
HLA-A major histocompatibility complex, class I, A -0.0218989
ITSN1 intersectin 1 (SH3 domain protein) -0.0218369
SHB Src homology 2 domain containing adaptor protein B -0.0218332
PDIA3 protein disulfide isomerase family A, member 3 -0.0216137
EIF5B eukaryotic translation initiation factor 5B -0.0215776
RPL19 ribosomal protein L19 -0.0214141
FMN1 formin 1 -0.021286
RPL9 ribosomal protein L9 -0.0210446