venetoclax_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description venetoclax perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the venetoclax_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.190364
COL5A2 collagen, type V, alpha 2 0.141741
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.106755
PM20D1 peptidase M20 domain containing 1 0.0870225
PDLIM5 PDZ and LIM domain 5 0.0771628
KYNU kynureninase 0.076547
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.065386
P3H2 prolyl 3-hydroxylase 2 0.0650912
DST dystonin 0.0613886
AGTPBP1 ATP/GTP binding protein 1 0.05754
COL8A1 collagen, type VIII, alpha 1 0.0564866
ASPH aspartate beta-hydroxylase 0.055165
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0541071
LSAMP limbic system-associated membrane protein 0.0538073
PDE10A phosphodiesterase 10A 0.0489759
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.044974
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0443762
PRKN parkin RBR E3 ubiquitin protein ligase 0.0429006
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0419039
NT5C2 5'-nucleotidase, cytosolic II 0.0408577
SH3KBP1 SH3-domain kinase binding protein 1 0.0401995
MAP7 microtubule-associated protein 7 0.0394843
EXT1 exostosin glycosyltransferase 1 0.0381894
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0348462
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0340233
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0331879
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0314513
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0305901
ENO1 enolase 1, (alpha) 0.0300443
MYOF myoferlin 0.0294716
HSPA8 heat shock 70kDa protein 8 0.0293654
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.029141
TPT1 tumor protein, translationally-controlled 1 0.0291329
NTN4 netrin 4 0.0283748
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0283204
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0280241
LGALS3 lectin, galactoside-binding, soluble, 3 0.028014
CD109 CD109 molecule 0.0273341
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0272991
WARS1 tryptophanyl-tRNA synthetase 1 0.0269721
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0265594
RAB3B RAB3B, member RAS oncogene family 0.0260628
ESYT2 extended synaptotagmin-like protein 2 0.0259269
RAD51B RAD51 paralog B 0.0259089
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0252514
SAMD4A sterile alpha motif domain containing 4A 0.025233
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0252262
ANTXR1 anthrax toxin receptor 1 0.0250482
SMAD2 SMAD family member 2 0.0248489
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0245094
PCDH15 protocadherin-related 15 0.0245092
ZSWIM6 zinc finger, SWIM-type containing 6 0.024045
BZW1 basic leucine zipper and W2 domains 1 0.0239922
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.0236429
LDHA lactate dehydrogenase A 0.0236037
XYLT1 xylosyltransferase I 0.023398
RPLP1 ribosomal protein, large, P1 0.0232658
CTIF CBP80/20-dependent translation initiation factor 0.0230327
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0228255
ZEB2 zinc finger E-box binding homeobox 2 0.0227532
SQSTM1 sequestosome 1 0.022713
PTPRM protein tyrosine phosphatase, receptor type, M 0.0217776
OASL 2'-5'-oligoadenylate synthetase-like 0.0217491
WWOX WW domain containing oxidoreductase 0.0217471
RIGI RNA sensor RIG-I 0.021646
EZR ezrin 0.0216088
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0215913
KRT19 keratin 19, type I 0.0214704
PRELID2 PRELI domain containing 2 0.02131
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0212807
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0212259
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0211935
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0208938
NRXN3 neurexin 3 0.0207638
IFIH1 interferon induced with helicase C domain 1 0.0206524
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0204696
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0201782
SMOC1 SPARC related modular calcium binding 1 0.0200362
ATXN1 ataxin 1 0.0199041
RPS6 ribosomal protein S6 0.0198149
TTC28 tetratricopeptide repeat domain 28 0.0194626
PALLD palladin, cytoskeletal associated protein 0.0193186
RPL4 ribosomal protein L4 0.0189096
CADM2 cell adhesion molecule 2 0.0188799
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0186226
DGKD diacylglycerol kinase, delta 130kDa 0.0184819
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0178609
TGFBR1 transforming growth factor, beta receptor 1 0.0176168
TENM2 teneurin transmembrane protein 2 0.0175067
RPLP0 ribosomal protein, large, P0 0.0172997
GREM2 gremlin 2, DAN family BMP antagonist 0.0171748
CHSY3 chondroitin sulfate synthase 3 0.0169857
RPS8 ribosomal protein S8 0.016449
OXSR1 oxidative stress responsive 1 0.0162588
CDH13 cadherin 13 0.0161512
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0161477
IRS2 insulin receptor substrate 2 0.0160375
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0160094
DISP1 dispatched homolog 1 (Drosophila) 0.0159202
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.0158881

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.200809
EFNA5 ephrin-A5 -0.12854
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.118855
IGFBP3 insulin-like growth factor binding protein 3 -0.102614
NAMPT nicotinamide phosphoribosyltransferase -0.0880246
MCL1 myeloid cell leukemia 1 -0.0815339
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0800398
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0670704
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0597067
STC1 stanniocalcin 1 -0.0581536
NPAS2 neuronal PAS domain protein 2 -0.0540252
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0495759
TFPI2 tissue factor pathway inhibitor 2 -0.0484687
TM4SF1 transmembrane 4 L six family member 1 -0.0479476
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0479405
LIMCH1 LIM and calponin homology domains 1 -0.0477505
NRCAM neuronal cell adhesion molecule -0.047556
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0474673
RTN4 reticulon 4 -0.046899
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0437119
PTMA prothymosin, alpha -0.0431194
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0411937
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0409769
GDA guanine deaminase -0.0405972
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0388498
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0387756
NDRG1 N-myc downstream regulated 1 -0.0386647
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0368967
EGR1 early growth response 1 -0.0355236
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0354533
BIRC6 baculoviral IAP repeat containing 6 -0.0337667
COL4A6 collagen, type IV, alpha 6 -0.0335946
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0328253
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.031992
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0318485
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0305323
KMT2E lysine (K)-specific methyltransferase 2E -0.0291039
GOLGA4 golgin A4 -0.0279791
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0279725
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0273832
RTN1 reticulon 1 -0.0271539
TGFBI transforming growth factor, beta-induced, 68kDa -0.0270784
DOCK4 dedicator of cytokinesis 4 -0.026954
S100A6 S100 calcium binding protein A6 -0.0268915
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0268638
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0260899
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0256919
COPA coatomer protein complex, subunit alpha -0.025459
FLNB filamin B, beta -0.0253842
GLIS3 GLIS family zinc finger 3 -0.0252671
PDGFA platelet-derived growth factor alpha polypeptide -0.0251637
MAML3 mastermind-like 3 (Drosophila) -0.0248665
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0247209
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0246571
GARS1 glycyl-tRNA synthetase 1 -0.0246003
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0237708
PCBP3 poly(rC) binding protein 3 -0.0236386
VDAC1 voltage-dependent anion channel 1 -0.0233939
SLC38A2 solute carrier family 38, member 2 -0.0231604
LAMB1 laminin, beta 1 -0.0230103
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0221709
FNDC3B fibronectin type III domain containing 3B -0.0219968
PDIA6 protein disulfide isomerase family A, member 6 -0.0219702
OGA O-GlcNAcase -0.021906
WDR45B WD repeat domain 45B -0.0215683
TMSB10 thymosin beta 10 -0.021552
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0211952
PRRC2C proline-rich coiled-coil 2C -0.0209973
SRPK2 SRSF protein kinase 2 -0.0207449
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0207423
FTH1 ferritin, heavy polypeptide 1 -0.0205831
MAP4 microtubule-associated protein 4 -0.0205204
LAMA5 laminin, alpha 5 -0.0204934
BMERB1 bMERB domain containing 1 -0.0203749
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0203309
PBX1 pre-B-cell leukemia homeobox 1 -0.0202186
MON2 MON2 homolog (S. cerevisiae) -0.0201709
AVL9 AVL9 homolog (S. cerevisiase) -0.0200788
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0199611
MAML2 mastermind-like 2 (Drosophila) -0.0197696
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0195093
RBM39 RNA binding motif protein 39 -0.0194524
LMAN1 lectin, mannose-binding, 1 -0.0192378
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0190828
DPYD dihydropyrimidine dehydrogenase -0.0190633
NUP58 nucleoporin 58 -0.0189037
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0188217
NCKAP5 NCK-associated protein 5 -0.0187173
STC2 stanniocalcin 2 -0.0184327
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0184254
ANKRD11 ankyrin repeat domain 11 -0.0183546
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.0183405
FTL ferritin, light polypeptide -0.0178839
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.017867
SETD5 SET domain containing 5 -0.0178481
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0177609
TPD52 tumor protein D52 -0.0177343
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0176251
SEC31A SEC31 homolog A (S. cerevisiae) -0.0175921
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0174178