venetoclax_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description venetoclax perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the venetoclax_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.187192
ERBB4 erb-b2 receptor tyrosine kinase 4 0.154817
VIM vimentin 0.132414
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.128521
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.127182
COL5A2 collagen, type V, alpha 2 0.12464
CADM2 cell adhesion molecule 2 0.118339
PCDH9 protocadherin 9 0.102396
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0962461
COL11A1 collagen, type XI, alpha 1 0.0825574
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0680211
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0655546
PEG10 paternally expressed 10 0.0638839
NAP1L1 nucleosome assembly protein 1-like 1 0.0586475
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0571224
TOP2A topoisomerase (DNA) II alpha 170kDa 0.05666
RPS8 ribosomal protein S8 0.0564995
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0558079
RPS6 ribosomal protein S6 0.054916
RPL23 ribosomal protein L23 0.0547224
TENM3 teneurin transmembrane protein 3 0.0541997
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0523055
ENO1 enolase 1, (alpha) 0.0481388
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0479388
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0474897
METAP2 methionyl aminopeptidase 2 0.0472048
CDH19 cadherin 19, type 2 0.0471943
MKI67 marker of proliferation Ki-67 0.0462563
RPS12 ribosomal protein S12 0.04568
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.043753
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0425032
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0420202
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0412023
PCLO piccolo presynaptic cytomatrix protein 0.0411934
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0400913
DST dystonin 0.0379401
RPL37 ribosomal protein L37 0.0370863
KTN1 kinectin 1 (kinesin receptor) 0.0363712
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.036082
RPL12 ribosomal protein L12 0.0342972
NPAS3 neuronal PAS domain protein 3 0.0342684
RPL11 ribosomal protein L11 0.034217
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0329026
MYO9A myosin IXA 0.0328667
RAD21 RAD21 homolog (S. pombe) 0.0326355
PDE4D phosphodiesterase 4D, cAMP-specific 0.0312694
EXOC4 exocyst complex component 4 0.03101
KIF5B kinesin family member 5B 0.0308604
PDIA3 protein disulfide isomerase family A, member 3 0.030596
CENPF centromere protein F, 350/400kDa 0.0302019
ANXA1 annexin A1 0.0295206
RPL37A ribosomal protein L37a 0.0290567
NBEAL1 neurobeachin-like 1 0.0280574
RPL21 ribosomal protein L21 0.0278684
TBC1D5 TBC1 domain family, member 5 0.0277466
CANX calnexin 0.0277451
ATAD2 ATPase family, AAA domain containing 2 0.0277376
TMSB4X thymosin beta 4, X-linked 0.0277158
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0276796
SET SET nuclear proto-oncogene 0.027669
RPLP0 ribosomal protein, large, P0 0.027355
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0272709
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0272363
PGK1 phosphoglycerate kinase 1 0.0272174
COL3A1 collagen, type III, alpha 1 0.0269211
MED12L mediator complex subunit 12-like 0.0262344
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0261958
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0259421
ASPH aspartate beta-hydroxylase 0.0257042
MATR3 matrin 3 0.0255126
FXR1 fragile X mental retardation, autosomal homolog 1 0.0254378
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0252546
ADGRV1 adhesion G protein-coupled receptor V1 0.0247614
ANKRD11 ankyrin repeat domain 11 0.0247319
AKAP12 A kinase (PRKA) anchor protein 12 0.0246634
HMGB2 high mobility group box 2 0.0245819
RPS3 ribosomal protein S3 0.0245528
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0243376
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0239966
KIF4A kinesin family member 4A 0.0239826
ERRFI1 ERBB receptor feedback inhibitor 1 0.0237113
SKIL SKI-like proto-oncogene 0.0235334
PAPOLA poly(A) polymerase alpha 0.0234051
TPX2 TPX2, microtubule-associated 0.0233505
CSDE1 cold shock domain containing E1, RNA-binding 0.0233018
PCDH7 protocadherin 7 0.0229886
WWC2 WW and C2 domain containing 2 0.0229381
RPS16 ribosomal protein S16 0.0228788
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0228613
TPR translocated promoter region, nuclear basket protein 0.0228522
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0228042
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0227174
RO60 Ro60, Y RNA binding protein 0.0225786
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0225464
RPL26 ribosomal protein L26 0.0225371
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0225112
XPO1 exportin 1 0.0224171
ZBTB20 zinc finger and BTB domain containing 20 0.0221819
GPC3 glypican 3 0.0220868
COL1A2 collagen, type I, alpha 2 0.0220721

decreased expression

Symbol Name Standardized Value
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0692783
SAMD4A sterile alpha motif domain containing 4A -0.0655534
TSC22D2 TSC22 domain family, member 2 -0.0549517
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0545077
PHIP pleckstrin homology domain interacting protein -0.052719
PRKD1 protein kinase D1 -0.0468348
NTM neurotrimin -0.0431121
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0430309
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0400502
ZNF217 zinc finger protein 217 -0.0380721
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0368492
LPIN2 lipin 2 -0.0365928
MRPS6 mitochondrial ribosomal protein S6 -0.0362153
CCN2 cellular communication network factor 2 -0.034973
GSE1 Gse1 coiled-coil protein -0.0332984
TMSB10 thymosin beta 10 -0.0329373
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0325471
CAMTA1 calmodulin binding transcription activator 1 -0.0319366
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0313438
NCOA2 nuclear receptor coactivator 2 -0.0312011
NCOR2 nuclear receptor corepressor 2 -0.0308747
WSB1 WD repeat and SOCS box containing 1 -0.0307202
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.030674
SREBF2 sterol regulatory element binding transcription factor 2 -0.0297303
ZFAND3 zinc finger, AN1-type domain 3 -0.0296234
ACTN4 actinin, alpha 4 -0.0290196
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.028819
MDK midkine (neurite growth-promoting factor 2) -0.0287923
TRPS1 trichorhinophalangeal syndrome I -0.0287762
NEBL nebulette -0.0286982
TBL1X transducin (beta)-like 1X-linked -0.0283605
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0282437
NHSL1 NHS-like 1 -0.0279637
SRPK2 SRSF protein kinase 2 -0.0279402
PUM2 pumilio RNA-binding family member 2 -0.0278715
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0277302
BMPR1A bone morphogenetic protein receptor, type IA -0.0275761
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0273991
PARD3B par-3 family cell polarity regulator beta -0.027379
ASXL1 additional sex combs like transcriptional regulator 1 -0.026368
USP25 ubiquitin specific peptidase 25 -0.0263487
BRWD1 bromodomain and WD repeat domain containing 1 -0.0262061
ATXN2 ataxin 2 -0.0261784
LOC112694756 uncharaterized LOC112694756 -0.0261345
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -0.0260406
ANKRD33B ankyrin repeat domain 33B -0.0260297
ZFP64 ZFP64 zinc finger protein -0.0256943
CECR2 cat eye syndrome chromosome region, candidate 2 -0.0253628
CHD1 chromodomain helicase DNA binding protein 1 -0.0245855
NXN nucleoredoxin -0.0243798
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.023987
RCOR1 REST corepressor 1 -0.0235037
MYO10 myosin X -0.0232795
KMT2C lysine (K)-specific methyltransferase 2C -0.022855
SLC44A5 solute carrier family 44, member 5 -0.0225673
TAPBP TAP binding protein (tapasin) -0.022478
DLG1 discs, large homolog 1 (Drosophila) -0.0224503
MTCL1 microtubule crosslinking factor 1 -0.0223844
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0223695
SETD5 SET domain containing 5 -0.0221741
CERT1 ceramide transporter 1 -0.0218574
HDAC9 histone deacetylase 9 -0.0216607
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0216571
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0212636
GARRE1 granule associated Rac and RHOG effector 1 -0.0211091
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0210792
MIDEAS mitotic deacetylase associated SANT domain protein -0.0208998
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.020839
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0206698
PRRC2B proline-rich coiled-coil 2B -0.0205172
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0202635
NRG1 neuregulin 1 -0.0199578
KCTD16 potassium channel tetramerization domain containing 16 -0.01994
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0198938
TNRC18 trinucleotide repeat containing 18 -0.0197027
STRN3 striatin, calmodulin binding protein 3 -0.0196038
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0195439
ADGRL1 adhesion G protein-coupled receptor L1 -0.0194867
RAB7A RAB7A, member RAS oncogene family -0.0194156
HMGA1 high mobility group AT-hook 1 -0.0192775
SRP54 signal recognition particle 54kDa -0.0191718
TRIO trio Rho guanine nucleotide exchange factor -0.0191357
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0191155
TTC28 tetratricopeptide repeat domain 28 -0.0191012
GARS1 glycyl-tRNA synthetase 1 -0.0190667
ATXN1 ataxin 1 -0.0189546
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0189353
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0188281
ZNF292 zinc finger protein 292 -0.0187213
GOLPH3 golgi phosphoprotein 3 (coat-protein) -0.0187074
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0184346
GNAS GNAS complex locus -0.0184023
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0180767
PARD3 par-3 family cell polarity regulator -0.0175698
MRPS30 mitochondrial ribosomal protein S30 -0.0175409
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0174542
ITGAV integrin, alpha V -0.017398
GPC4 glypican 4 -0.0173659
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -0.0173569
SERTAD2 SERTA domain containing 2 -0.0172822