venetoclax_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description venetoclax perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the venetoclax_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0943878
ERRFI1 ERBB receptor feedback inhibitor 1 0.0797131
ZSWIM6 zinc finger, SWIM-type containing 6 0.0746896
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0685849
CXCL8 chemokine (C-X-C motif) ligand 8 0.0505648
KYNU kynureninase 0.0491081
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0483171
EXT1 exostosin glycosyltransferase 1 0.0446449
CANX calnexin 0.043834
FNIP1 folliculin interacting protein 1 0.0427433
MACF1 microtubule-actin crosslinking factor 1 0.0400154
PRELID2 PRELI domain containing 2 0.0390815
GOLGB1 golgin B1 0.0376513
NRXN3 neurexin 3 0.0375649
SOD2 superoxide dismutase 2, mitochondrial 0.0367812
INTS6 integrator complex subunit 6 0.0355677
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0337268
DPYD dihydropyrimidine dehydrogenase 0.0334591
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0320967
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0319407
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0314921
LDHA lactate dehydrogenase A 0.0312582
ATXN1 ataxin 1 0.0310412
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0308475
FBXL7 F-box and leucine-rich repeat protein 7 0.0307776
CD44 CD44 molecule (Indian blood group) 0.0294435
ZBTB20 zinc finger and BTB domain containing 20 0.0289724
ARB2A ARB2 cotranscriptional regulator A 0.028523
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0282588
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0281219
CENPF centromere protein F, 350/400kDa 0.0279192
ANO6 anoctamin 6 0.0261793
PTGES2 prostaglandin E synthase 2 0.0261584
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0260637
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0258416
ATP13A3 ATPase type 13A3 0.0246815
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0246707
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0245107
ARHGAP24 Rho GTPase activating protein 24 0.0242465
TMF1 TATA element modulatory factor 1 0.0240463
RBMS3 RNA binding motif, single stranded interacting protein 3 0.023764
MBD5 methyl-CpG binding domain protein 5 0.0237579
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0236601
HMGB2 high mobility group box 2 0.0235735
AHR aryl hydrocarbon receptor 0.0231486
SERINC1 serine incorporator 1 0.0228988
STC1 stanniocalcin 1 0.0227092
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0226103
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0225586
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0224407
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0218774
ANKRD36 ankyrin repeat domain 36 0.0218562
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0217886
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0214403
BZW1 basic leucine zipper and W2 domains 1 0.0211325
PUM2 pumilio RNA-binding family member 2 0.0205859
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0205693
RND3 Rho family GTPase 3 0.0204472
CDC73 cell division cycle 73 0.0203837
MYSM1 Myb-like, SWIRM and MPN domains 1 0.0202851
CDH13 cadherin 13 0.0202038
MEF2A myocyte enhancer factor 2A 0.0198369
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0198133
HDLBP high density lipoprotein binding protein 0.0197996
TRA2A transformer 2 alpha homolog (Drosophila) 0.0197901
TRIO trio Rho guanine nucleotide exchange factor 0.0196988
ANLN anillin, actin binding protein 0.0195545
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0194421
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0191661
IL6ST interleukin 6 signal transducer 0.0191386
SLC35F5 solute carrier family 35, member F5 0.0189564
PGM3 phosphoglucomutase 3 0.0186214
LTN1 listerin E3 ubiquitin protein ligase 1 0.0184646
AOPEP aminopeptidase O (putative) 0.0182507
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0180869
SDK1 sidekick cell adhesion molecule 1 0.0179157
SFPQ splicing factor proline/glutamine-rich 0.0178215
APOLD1 apolipoprotein L domain containing 1 0.0176297
PCM1 pericentriolar material 1 0.0174111
IFRD1 interferon-related developmental regulator 1 0.0173999
PUM1 pumilio RNA-binding family member 1 0.0173726
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.017358
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0172441
FAM13A family with sequence similarity 13, member A 0.0171251
KIF16B kinesin family member 16B 0.0170082
PALLD palladin, cytoskeletal associated protein 0.0169947
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0169917
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0169663
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0168959
GBP2 guanylate binding protein 2, interferon-inducible 0.0168335
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0167255
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0166852
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0165753
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0165094
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0164263
TP53BP1 tumor protein p53 binding protein 1 0.0164195
SGO2 shugoshin 2 0.016416
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0163338
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0162717
EIF4H eukaryotic translation initiation factor 4H 0.0162604

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.255935
MT2A metallothionein 2A -0.233964
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.227859
HLA-B major histocompatibility complex, class I, B -0.158709
TGFBI transforming growth factor, beta-induced, 68kDa -0.155793
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.15516
VIM vimentin -0.145026
B2M beta-2-microglobulin -0.113196
PTMA prothymosin, alpha -0.0827591
FTL ferritin, light polypeptide -0.0820713
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0775566
IGFBP3 insulin-like growth factor binding protein 3 -0.0753537
COL1A1 collagen, type I, alpha 1 -0.0709378
TPT1 tumor protein, translationally-controlled 1 -0.067385
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0634189
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0612333
NDRG1 N-myc downstream regulated 1 -0.05952
MT1X metallothionein 1X -0.0584168
RPS6 ribosomal protein S6 -0.0581876
COL1A2 collagen, type I, alpha 2 -0.0577753
VEGFA vascular endothelial growth factor A -0.0532344
COL6A1 collagen, type VI, alpha 1 -0.0521775
S100A6 S100 calcium binding protein A6 -0.0517924
PKM pyruvate kinase, muscle -0.0515633
POTEF POTE ankyrin domain family, member F -0.0515035
RPLP1 ribosomal protein, large, P1 -0.0495043
RPL35A ribosomal protein L35a -0.0485164
COL6A3 collagen, type VI, alpha 3 -0.0466177
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0462414
ACTG1 actin gamma 1 -0.0457711
HLA-C major histocompatibility complex, class I, C -0.0453853
EGR1 early growth response 1 -0.0453703
LGALS1 lectin, galactoside-binding, soluble, 1 -0.043998
RTN4 reticulon 4 -0.0408125
S100A9 S100 calcium binding protein A9 -0.0403017
FN1 fibronectin 1 -0.0402739
RPL11 ribosomal protein L11 -0.0398745
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.038354
RPL36 ribosomal protein L36 -0.0381946
RPL28 ribosomal protein L28 -0.0379686
RPL19 ribosomal protein L19 -0.0370322
H3-3B H3.3 histone B -0.0365184
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0356988
RPS19 ribosomal protein S19 -0.0353632
ANKRD11 ankyrin repeat domain 11 -0.0350864
FTH1 ferritin, heavy polypeptide 1 -0.0349261
GARS1 glycyl-tRNA synthetase 1 -0.0347461
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0344565
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.034453
TAGLN2 transgelin 2 -0.0339206
LOX lysyl oxidase -0.0336572
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0333922
ADM adrenomedullin -0.0330939
TPM1 tropomyosin 1 (alpha) -0.032994
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0327869
UBC ubiquitin C -0.0317791
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0313284
F3 coagulation factor III (thromboplastin, tissue factor) -0.0312111
RPL34 ribosomal protein L34 -0.0308939
AKAP12 A kinase (PRKA) anchor protein 12 -0.0308365
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0298323
WSB1 WD repeat and SOCS box containing 1 -0.0294945
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0291887
FOSL1 FOS-like antigen 1 -0.028966
RPS8 ribosomal protein S8 -0.0284986
RPL12 ribosomal protein L12 -0.02804
S100A10 S100 calcium binding protein A10 -0.0277037
RPL23 ribosomal protein L23 -0.0271189
TPM4 tropomyosin 4 -0.0267304
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0266832
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0265139
COL7A1 collagen, type VII, alpha 1 -0.0263903
RBM39 RNA binding motif protein 39 -0.0262007
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0252829
GPC6 glypican 6 -0.025244
RPS23 ribosomal protein S23 -0.0250947
RPL31 ribosomal protein L31 -0.0248704
STC2 stanniocalcin 2 -0.0247987
SEPTIN9 septin 9 -0.0246551
ZMYND8 zinc finger, MYND-type containing 8 -0.024603
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0245962
EIF1 eukaryotic translation initiation factor 1 -0.0239958
PSD3 pleckstrin and Sec7 domain containing 3 -0.0238493
PRRC2C proline-rich coiled-coil 2C -0.0237373
TPI1 triosephosphate isomerase 1 -0.0236073
CA9 carbonic anhydrase IX -0.0235616
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0235309
NRP1 neuropilin 1 -0.0230652
RPS27 ribosomal protein S27 -0.0230184
IGFBP7 insulin-like growth factor binding protein 7 -0.0229329
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0225839
SEC61G Sec61 gamma subunit -0.0225471
RPL37A ribosomal protein L37a -0.0225468
RPS25 ribosomal protein S25 -0.0224683
RPL8 ribosomal protein L8 -0.0224452
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0224411
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0224127
COL6A2 collagen, type VI, alpha 2 -0.0223935
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0222402
ERBIN erbb2 interacting protein -0.0217702