verapamil-5387 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the verapamil-5387 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
AFAP1 actin filament associated protein 1
AGTR1 angiotensin II receptor, type 1
AOC2 amine oxidase, copper containing 2 (retina-specific)
APOC1 apolipoprotein C-I
APOE apolipoprotein E
ARG1 arginase 1
ATN1 atrophin 1
BEX1 brain expressed, X-linked 1
C3ORF18 chromosome 3 open reading frame 18
CA4 carbonic anhydrase IV
CALCR calcitonin receptor
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CASP2 caspase 2, apoptosis-related cysteine peptidase
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CEP135 centrosomal protein 135kDa
CLCN7 chloride channel, voltage-sensitive 7
CPB1 carboxypeptidase B1 (tissue)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DLX5 distal-less homeobox 5
DSPP dentin sialophosphoprotein
EFNB3 ephrin-B3
EGR3 early growth response 3
EXOC6B exocyst complex component 6B
FBXL7 F-box and leucine-rich repeat protein 7
FHL1 four and a half LIM domains 1
FOSL2 FOS-like antigen 2
FRMPD1 FERM and PDZ domain containing 1
FSCN1 fascin actin-bundling protein 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLRA2 glycine receptor, alpha 2
GRB7 growth factor receptor-bound protein 7
GRM1 glutamate receptor, metabotropic 1
GRM6 glutamate receptor, metabotropic 6
HCAR3 hydroxycarboxylic acid receptor 3
HCFC1 host cell factor C1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IL1R2 interleukin 1 receptor, type II
IMPG2 interphotoreceptor matrix proteoglycan 2
JMJD4 jumonji domain containing 4
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLHL25 kelch-like family member 25
LEPR leptin receptor
LINC00312 long intergenic non-protein coding RNA 312
LINC00597 long intergenic non-protein coding RNA 597
LOXL3 lysyl oxidase-like 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP2K5 mitogen-activated protein kinase kinase 5
MAPK11 mitogen-activated protein kinase 11
MAPK7 mitogen-activated protein kinase 7
MASP2 mannan-binding lectin serine peptidase 2
MAST3 microtubule associated serine/threonine kinase 3
MKL1 megakaryoblastic leukemia (translocation) 1
MSR1 macrophage scavenger receptor 1
MTMR8 myotubularin related protein 8
MYO7A myosin VIIA
NCR2 natural cytotoxicity triggering receptor 2
NEUROD1 neuronal differentiation 1
NFRKB nuclear factor related to kappaB binding protein
NOS1 nitric oxide synthase 1 (neuronal)
NT5M 5',3'-nucleotidase, mitochondrial
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR3A3 olfactory receptor, family 3, subfamily A, member 3
PARVA parvin, alpha
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH7 protocadherin 7
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PTCRA pre T-cell antigen receptor alpha
RAB6A RAB6A, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RGS14 regulator of G-protein signaling 14
SAFB scaffold attachment factor B
SFTPB surfactant protein B
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SIK3 SIK family kinase 3
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULT4A1 sulfotransferase family 4A, member 1
SYNC syncoilin, intermediate filament protein
TAPBP TAP binding protein (tapasin)
TIMP4 TIMP metallopeptidase inhibitor 4
TLDC1 TBC/LysM-associated domain containing 1
TMCC2 transmembrane and coiled-coil domain family 2
TMEM63A transmembrane protein 63A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOX thymocyte selection-associated high mobility group box
TRAF3IP3 TRAF3 interacting protein 3
TREX1 three prime repair exonuclease 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZNF34 zinc finger protein 34
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACSL4 acyl-CoA synthetase long-chain family member 4
ACTL8 actin-like 8
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAM15 ADAM metallopeptidase domain 15
ADAP2 ArfGAP with dual PH domains 2
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
BAGE B melanoma antigen
C17ORF70 chromosome 17 open reading frame 70
C5ORF45 chromosome 5 open reading frame 45
C6ORF47 chromosome 6 open reading frame 47
C9ORF9 chromosome 9 open reading frame 9
CAMK1 calcium/calmodulin-dependent protein kinase I
CAPG capping protein (actin filament), gelsolin-like
CCDC186 coiled-coil domain containing 186
CCDC85C coiled-coil domain containing 85C
CCDC88C coiled-coil domain containing 88C
CCDC9 coiled-coil domain containing 9
CD79B CD79b molecule, immunoglobulin-associated beta
CD82 CD82 molecule
CD8A CD8a molecule
CES3 carboxylesterase 3
CLIC2 chloride intracellular channel 2
CPPED1 calcineurin-like phosphoesterase domain containing 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTSF cathepsin F
EGFL7 EGF-like-domain, multiple 7
FAM131A family with sequence similarity 131, member A
FAM189A2 family with sequence similarity 189, member A2
FAM212B family with sequence similarity 212, member B
FAM46C family with sequence similarity 46, member C
FBXL6 F-box and leucine-rich repeat protein 6
FBXO22 F-box protein 22
FLT4 fms-related tyrosine kinase 4
FOSL1 FOS-like antigen 1
FOXN2 forkhead box N2
GEMIN8 gem (nuclear organelle) associated protein 8
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GJA9 gap junction protein, alpha 9, 59kDa
GLS2 glutaminase 2 (liver, mitochondrial)
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BJ histone cluster 1, H2bj
HOXC5 homeobox C5
HOXD11 homeobox D11
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IL17RA interleukin 17 receptor A
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITPKB inositol-trisphosphate 3-kinase B
KLK5 kallikrein-related peptidase 5
LARP6 La ribonucleoprotein domain family, member 6
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LHX6 LIM homeobox 6
LOC202181 SUMO-interacting motifs containing 1 pseudogene
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MCOLN1 mucolipin 1
METTL2B methyltransferase like 2B
MXD3 MAX dimerization protein 3
NEB nebulin
NME5 NME/NM23 family member 5
NPM3 nucleophosmin/nucleoplasmin 3
NRSN2 neurensin 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PCDHA6 protocadherin alpha 6
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PMCH pro-melanin-concentrating hormone
POM121 POM121 transmembrane nucleoporin
PRPH peripherin
QSER1 glutamine and serine rich 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAI2 retinoic acid induced 2
SAYSD1 SAYSVFN motif domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SH2B3 SH2B adaptor protein 3
SNAI2 snail family zinc finger 2
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
ST5 suppression of tumorigenicity 5
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D19 TBC1 domain family, member 19
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCHH trichohyalin
TMEM120B transmembrane protein 120B
TMEM212 transmembrane protein 212
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNS2 tensin 2
TPCN1 two pore segment channel 1
TRABD TraB domain containing
TUBA3C tubulin, alpha 3c
UNC93B1 unc-93 homolog B1 (C. elegans)