vhl Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase|Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7428)
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Genes

77 genes co-occuring with the biological term vhl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AR androgen receptor
ARHGAP35 Rho GTPase activating protein 35
ARNT aryl hydrocarbon receptor nuclear translocator
ATRX alpha thalassemia/mental retardation syndrome X-linked
AURKA aurora kinase A
BRCA1 breast cancer 1, early onset
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
CA9 carbonic anhydrase IX
CAMP cathelicidin antimicrobial peptide
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBX5 chromobox homolog 5
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHGA chromogranin A
CHGB chromogranin B
CLDN1 claudin 1
CLU clusterin
COL1A1 collagen, type I, alpha 1
CTGF connective tissue growth factor
CXCR4 chemokine (C-X-C motif) receptor 4
CYBA cytochrome b-245, alpha polypeptide
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
EGFR epidermal growth factor receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EPAS1 endothelial PAS domain protein 1
EPO erythropoietin
EPOR erythropoietin receptor
FHIT fragile histidine triad
GLI1 GLI family zinc finger 1
HDAC1 histone deacetylase 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
IGF1R insulin-like growth factor 1 receptor
JUNB jun B proto-oncogene
KDM5C lysine (K)-specific demethylase 5C
KLF10 Kruppel-like factor 10
KRAS Kirsten rat sarcoma viral oncogene homolog
LIMD1 LIM domains containing 1
LMNA lamin A/C
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPK7 mitogen-activated protein kinase 7
MIR155 microRNA 155
MIR204 microRNA 204
MIR23B microRNA 23b
MIR566 microRNA 566
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NOX1 NADPH oxidase 1
NOX4 NADPH oxidase 4
OCLN occludin
PBRM1 polybromo 1
PIAS4 protein inhibitor of activated STAT, 4
PLA2R1 phospholipase A2 receptor 1, 180kDa
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PROK1 prokineticin 1
PTEN phosphatase and tensin homolog
RET ret proto-oncogene
RHOA ras homolog family member A
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SHH sonic hedgehog
SNAI1 snail family zinc finger 1
SOCS1 suppressor of cytokine signaling 1
SPP1 secreted phosphoprotein 1
TGFBI transforming growth factor, beta-induced, 68kDa
TP53 tumor protein p53
TPT1 tumor protein, translationally-controlled 1
TRPM3 transient receptor potential cation channel, subfamily M, member 3
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VTN vitronectin
ZEB2 zinc finger E-box binding homeobox 2
ZNF154 zinc finger protein 154