vincristine_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description vincristine perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the vincristine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.306438
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.160211
LDHA lactate dehydrogenase A 0.154871
TRIO trio Rho guanine nucleotide exchange factor 0.134917
POTEF POTE ankyrin domain family, member F 0.0969658
TPM4 tropomyosin 4 0.0918289
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.089348
MYH9 myosin, heavy chain 9, non-muscle 0.0855627
FLNA filamin A, alpha 0.0843682
PODXL podocalyxin-like 0.0815215
FLNB filamin B, beta 0.0792558
AKAP12 A kinase (PRKA) anchor protein 12 0.0782046
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0734242
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.072506
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0658014
PALM2AKAP2 PALM2 and AKAP2 fusion 0.062339
HDAC9 histone deacetylase 9 0.0619395
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0602818
CDH13 cadherin 13 0.0574464
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0569926
SAMD4A sterile alpha motif domain containing 4A 0.0559716
TPM3 tropomyosin 3 0.0540005
DST dystonin 0.0537338
NEK7 NIMA-related kinase 7 0.0521167
LMO7 LIM domain 7 0.0520402
ERBIN erbb2 interacting protein 0.0483464
APP amyloid beta (A4) precursor protein 0.0476
EXT1 exostosin glycosyltransferase 1 0.0463892
LIMCH1 LIM and calponin homology domains 1 0.0462868
PLAT plasminogen activator, tissue 0.0461935
ERRFI1 ERBB receptor feedback inhibitor 1 0.0461935
TENM3 teneurin transmembrane protein 3 0.0450049
TLE4 transducin-like enhancer of split 4 0.0449944
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0446271
COL5A2 collagen, type V, alpha 2 0.0437903
DOCK5 dedicator of cytokinesis 5 0.0429319
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0419101
MSN moesin 0.0417735
CD44 CD44 molecule (Indian blood group) 0.0414258
AXL AXL receptor tyrosine kinase 0.0410476
ACTG1 actin gamma 1 0.0407326
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0398072
COL8A1 collagen, type VIII, alpha 1 0.0387266
MCL1 myeloid cell leukemia 1 0.0380169
DCLK2 doublecortin-like kinase 2 0.037728
CCN2 cellular communication network factor 2 0.0371273
FMN2 formin 2 0.036601
ELL2 elongation factor, RNA polymerase II, 2 0.0365921
VCL vinculin 0.0352448
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0350643
CANX calnexin 0.0349742
MB21D2 Mab-21 domain containing 2 0.0346928
MYOF myoferlin 0.0346748
RUNX1 runt-related transcription factor 1 0.0341028
DPYSL2 dihydropyrimidinase-like 2 0.0335827
PLEC plectin 0.033081
RPL3 ribosomal protein L3 0.033055
ADAM9 ADAM metallopeptidase domain 9 0.0329722
MPRIP myosin phosphatase Rho interacting protein 0.0324477
DIAPH3 diaphanous-related formin 3 0.0312598
EEF2 eukaryotic translation elongation factor 2 0.0303704
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0297141
CDK6 cyclin-dependent kinase 6 0.0294364
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0294256
KRT18 keratin 18, type I 0.0292114
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0291469
ACTN4 actinin, alpha 4 0.028999
TUFT1 tuftelin 1 0.0289204
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0289136
MBNL2 muscleblind-like splicing regulator 2 0.0288121
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.027721
FSTL1 follistatin-like 1 0.0275317
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0271676
CORO1C coronin, actin binding protein, 1C 0.0265966
RND3 Rho family GTPase 3 0.0265635
PLK2 polo-like kinase 2 0.0264496
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0262796
SET SET nuclear proto-oncogene 0.0258568
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.0257468
NT5E 5'-nucleotidase, ecto (CD73) 0.0257432
PRELID2 PRELI domain containing 2 0.0256818
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0256231
BCL2L1 BCL2-like 1 0.0255563
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0255174
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0255021
PBX3 pre-B-cell leukemia homeobox 3 0.0253368
KATNAL1 katanin p60 subunit A-like 1 0.0251353
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 0.0247848
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0246416
LIMA1 LIM domain and actin binding 1 0.0246194
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0245125
CREB5 cAMP responsive element binding protein 5 0.0244232
AHNAK2 AHNAK nucleoprotein 2 0.0240668
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0239742
MITF microphthalmia-associated transcription factor 0.0238026
TXNRD1 thioredoxin reductase 1 0.0233528
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0232077
TPM1 tropomyosin 1 (alpha) 0.0231454
EIF4H eukaryotic translation initiation factor 4H 0.0230295
SRRM2 serine/arginine repetitive matrix 2 0.0227764

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.21934
VIM vimentin -0.197279
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.180769
PTMA prothymosin, alpha -0.0921342
CSTB cystatin B (stefin B) -0.0843057
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0731612
DLG1 discs, large homolog 1 (Drosophila) -0.070103
NAV1 neuron navigator 1 -0.0688873
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0638854
MT2A metallothionein 2A -0.0637287
NDRG1 N-myc downstream regulated 1 -0.0624829
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0618543
TUBB4B tubulin, beta 4B class IVb -0.0597761
IGFBP3 insulin-like growth factor binding protein 3 -0.0596899
S100A6 S100 calcium binding protein A6 -0.0593079
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0564517
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0553346
HLA-B major histocompatibility complex, class I, B -0.0549797
LMNA lamin A/C -0.0485173
ABI3BP ABI family, member 3 (NESH) binding protein -0.0485124
B2M beta-2-microglobulin -0.0479231
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0473483
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0469778
TPT1 tumor protein, translationally-controlled 1 -0.0458548
S100A10 S100 calcium binding protein A10 -0.0455108
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0444825
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0442768
TUBB tubulin, beta class I -0.0438439
SLC38A1 solute carrier family 38, member 1 -0.0429078
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0413304
FN1 fibronectin 1 -0.0400776
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0399753
IFIH1 interferon induced with helicase C domain 1 -0.0384376
THBS2 thrombospondin 2 -0.0371171
RPL35A ribosomal protein L35a -0.0367332
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0363862
BHLHE40 basic helix-loop-helix family, member e40 -0.0356408
MARCKS myristoylated alanine-rich protein kinase C substrate -0.034551
SLC39A11 solute carrier family 39, member 11 -0.0343754
SOD2 superoxide dismutase 2, mitochondrial -0.0338091
SAMD9 sterile alpha motif domain containing 9 -0.0335547
MX2 MX dynamin-like GTPase 2 -0.0332627
FTL ferritin, light polypeptide -0.0317186
INSIG1 insulin induced gene 1 -0.0317083
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0310211
FNDC3A fibronectin type III domain containing 3A -0.0302494
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0298242
TUBA1B tubulin, alpha 1b -0.0295462
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0294649
GPC6 glypican 6 -0.0290851
OASL 2'-5'-oligoadenylate synthetase-like -0.0289776
SH3KBP1 SH3-domain kinase binding protein 1 -0.0289519
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0289186
RIGI RNA sensor RIG-I -0.028677
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0284515
S100A11 S100 calcium binding protein A11 -0.028126
RPL37A ribosomal protein L37a -0.028041
RPS24 ribosomal protein S24 -0.0279531
PRRC2C proline-rich coiled-coil 2C -0.0261981
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0261885
RPLP1 ribosomal protein, large, P1 -0.0260603
TUBA1C tubulin, alpha 1c -0.0253285
KDM3A lysine (K)-specific demethylase 3A -0.0252411
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0248176
VDAC1 voltage-dependent anion channel 1 -0.0247339
FLT1 fms-related tyrosine kinase 1 -0.0246004
SORBS2 sorbin and SH3 domain containing 2 -0.0243323
ZMYND8 zinc finger, MYND-type containing 8 -0.0241417
PDE4D phosphodiesterase 4D, cAMP-specific -0.0237087
IFI16 interferon, gamma-inducible protein 16 -0.0236317
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0231968
RPL34 ribosomal protein L34 -0.0230999
RRBP1 ribosome binding protein 1 -0.0228948
RPS27A ribosomal protein S27a -0.0223949
RPL31 ribosomal protein L31 -0.0221877
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.022142
HLA-C major histocompatibility complex, class I, C -0.0216396
ISG15 ISG15 ubiquitin-like modifier -0.0215645
SEC61G Sec61 gamma subunit -0.0215513
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0213166
SOX9 SRY (sex determining region Y)-box 9 -0.0212929
KPNB1 karyopherin (importin) beta 1 -0.0212574
RPLP2 ribosomal protein, large, P2 -0.0208354
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0207657
WARS1 tryptophanyl-tRNA synthetase 1 -0.0206939
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0204294
RPL38 ribosomal protein L38 -0.0204248
AUTS2 autism susceptibility candidate 2 -0.0203383
RPS6 ribosomal protein S6 -0.0202972
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0195964
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0192687
RPS19 ribosomal protein S19 -0.0192225
ZEB1 zinc finger E-box binding homeobox 1 -0.0191568
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0191383
RPL12 ribosomal protein L12 -0.0190268
MPZL1 myelin protein zero-like 1 -0.0188568
SQSTM1 sequestosome 1 -0.0187866
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.018655
RPS8 ribosomal protein S8 -0.0185499
IER3 immediate early response 3 -0.0183884