vincristine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description vincristine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the vincristine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.189581
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.13537
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.107956
ACTG1 actin gamma 1 0.100458
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0782419
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0764268
PTMA prothymosin, alpha 0.0745488
RPL23 ribosomal protein L23 0.0692303
VIM vimentin 0.0635478
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0616602
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0605869
RPS6 ribosomal protein S6 0.0571795
RPL37A ribosomal protein L37a 0.0548769
EEF2 eukaryotic translation elongation factor 2 0.0547736
EIF1 eukaryotic translation initiation factor 1 0.05069
MCL1 myeloid cell leukemia 1 0.0493373
RPL19 ribosomal protein L19 0.0484371
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0467851
RPL3 ribosomal protein L3 0.0427582
TRIO trio Rho guanine nucleotide exchange factor 0.0426517
TMSB10 thymosin beta 10 0.0421859
EXT1 exostosin glycosyltransferase 1 0.0401022
RPL13A ribosomal protein L13a 0.0395566
TPT1 tumor protein, translationally-controlled 1 0.0389359
PLAT plasminogen activator, tissue 0.0388626
RPS12 ribosomal protein S12 0.0387643
MYH9 myosin, heavy chain 9, non-muscle 0.0384977
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0383582
DST dystonin 0.0374407
ASPH aspartate beta-hydroxylase 0.0371645
CENPF centromere protein F, 350/400kDa 0.0371298
RPS3 ribosomal protein S3 0.0371032
LDHA lactate dehydrogenase A 0.0364001
RPL31 ribosomal protein L31 0.0346616
ZSWIM6 zinc finger, SWIM-type containing 6 0.0342393
RPLP1 ribosomal protein, large, P1 0.0341894
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0340342
SEPTIN9 septin 9 0.033937
VCL vinculin 0.0336396
RPS8 ribosomal protein S8 0.0334694
RPS17 ribosomal protein S17 0.0332311
PALM2AKAP2 PALM2 and AKAP2 fusion 0.032379
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0323543
NALF1 NALCN channel auxiliary factor 1 0.0316713
RPS19 ribosomal protein S19 0.0316397
RPS4X ribosomal protein S4, X-linked 0.0313563
POTEF POTE ankyrin domain family, member F 0.0313035
TRIB2 tribbles pseudokinase 2 0.0311612
RPS27A ribosomal protein S27a 0.0309145
PKM pyruvate kinase, muscle 0.0307684
SPTBN1 spectrin, beta, non-erythrocytic 1 0.030253
RPS23 ribosomal protein S23 0.0293888
DTNA dystrobrevin, alpha 0.0292086
DPH6 diphthamine biosynthesis 6 0.0288054
ENO1 enolase 1, (alpha) 0.0287769
PRRC2C proline-rich coiled-coil 2C 0.0283922
CANX calnexin 0.0283066
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0276222
NDRG1 N-myc downstream regulated 1 0.0275973
ERRFI1 ERBB receptor feedback inhibitor 1 0.0272601
PCBP2 poly(rC) binding protein 2 0.0267509
FTL ferritin, light polypeptide 0.0266764
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0264927
RPL7 ribosomal protein L7 0.0262813
STC1 stanniocalcin 1 0.0262012
IGFBP3 insulin-like growth factor binding protein 3 0.026195
LPIN1 lipin 1 0.026136
HSPA8 heat shock 70kDa protein 8 0.0261077
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0256876
RPL27 ribosomal protein L27 0.0256741
ITPRID2 ITPR interacting domain containing 2 0.0255923
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.025488
TPM4 tropomyosin 4 0.0253608
RPL11 ribosomal protein L11 0.0253085
RPL35A ribosomal protein L35a 0.0249295
NAP1L1 nucleosome assembly protein 1-like 1 0.0247643
BPTF bromodomain PHD finger transcription factor 0.0245945
AHNAK AHNAK nucleoprotein 0.0244048
ENAH enabled homolog (Drosophila) 0.0239004
RPL38 ribosomal protein L38 0.0237496
NES nestin 0.0236656
ADAR adenosine deaminase, RNA-specific 0.0236464
CSDE1 cold shock domain containing E1, RNA-binding 0.0235025
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0233354
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0232747
MKI67 marker of proliferation Ki-67 0.0232627
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0232185
SET SET nuclear proto-oncogene 0.0230571
SMYD3 SET and MYND domain containing 3 0.0229368
RPL4 ribosomal protein L4 0.0227871
ACTN1 actinin, alpha 1 0.022775
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.02275
NPAS2 neuronal PAS domain protein 2 0.0227185
APLP2 amyloid beta (A4) precursor-like protein 2 0.0226897
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0225986
ATXN1 ataxin 1 0.0225681
FMN1 formin 1 0.0225069
RPLP0 ribosomal protein, large, P0 0.0224457
RPL5 ribosomal protein L5 0.0223302
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0222669

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.169122
SYT1 synaptotagmin I -0.0486168
NRG1 neuregulin 1 -0.0483172
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0469439
TPST1 tyrosylprotein sulfotransferase 1 -0.028928
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0264308
TENT5A terminal nucleotidyltransferase 5A -0.0254327
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0232123
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0225298
FRMD4A FERM domain containing 4A -0.0221875
NCAM2 neural cell adhesion molecule 2 -0.0218169
MBD5 methyl-CpG binding domain protein 5 -0.0214714
COL4A5 collagen, type IV, alpha 5 -0.0213654
AOPEP aminopeptidase O (putative) -0.0208252
PDZRN3 PDZ domain containing ring finger 3 -0.0205471
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0202369
GREM2 gremlin 2, DAN family BMP antagonist -0.0187217
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0186363
MEIS2 Meis homeobox 2 -0.0184072
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0180917
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0173695
SIK2 salt-inducible kinase 2 -0.0172773
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.016999
PLPP1 phospholipid phosphatase 1 -0.0169535
NCOA7 nuclear receptor coactivator 7 -0.0164138
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.016051
NPEPPS aminopeptidase puromycin sensitive -0.0147429
CD46 CD46 molecule, complement regulatory protein -0.0146226
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -0.0145055
COL3A1 collagen, type III, alpha 1 -0.0142072
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0140252
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0135585
CD36 CD36 molecule (thrombospondin receptor) -0.013484
SYNPO2 synaptopodin 2 -0.0132217
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0130815
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.013016
NRP1 neuropilin 1 -0.0128493
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0122591
CNTN4 contactin 4 -0.0122282
PCNX1 pecanex 1 -0.0120119
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0119954
ZFC3H1 zinc finger, C3H1-type containing -0.0115059
GATAD2B GATA zinc finger domain containing 2B -0.011476
TMEM108 transmembrane protein 108 -0.0113526
KLHL13 kelch-like family member 13 -0.0112181
YME1L1 YME1-like 1 ATPase -0.0111871
PDE10A phosphodiesterase 10A -0.0108523
ITCH itchy E3 ubiquitin protein ligase -0.0106614
STOX2 storkhead box 2 -0.0105846
WAC WW domain containing adaptor with coiled-coil -0.0103591
TMEM263 transmembrane protein 263 -0.0103185
ACBD3 acyl-CoA binding domain containing 3 -0.010179
MON2 MON2 homolog (S. cerevisiae) -0.0101765
CEP95 centrosomal protein 95kDa -0.0101706
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 -0.0100836
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0100334
SRP54 signal recognition particle 54kDa -0.0100034
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.00998608
ARHGAP5 Rho GTPase activating protein 5 -0.00995949
USP15 ubiquitin specific peptidase 15 -0.00982503
RALYL RALY RNA binding protein-like -0.00981842
NBEA neurobeachin -0.00979591
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.00973001
MALT1 MALT1 paracaspase -0.00970004
SREBF2 sterol regulatory element binding transcription factor 2 -0.00964234
MX2 MX dynamin-like GTPase 2 -0.009638
IARS1 isoleucyl-tRNA synthetase 1 -0.00957674
IGFBP4 insulin-like growth factor binding protein 4 -0.00954708
GRK5 G protein-coupled receptor kinase 5 -0.00951878
MARCHF6 membrane associated ring-CH-type finger 6 -0.00951729
KLF7 Kruppel-like factor 7 (ubiquitous) -0.00915677
PRPF8 pre-mRNA processing factor 8 -0.00913144
ARHGAP24 Rho GTPase activating protein 24 -0.0091076
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.00909155
SEC24D SEC24 family member D -0.0090408
DLC1 DLC1 Rho GTPase activating protein -0.00896922
DNM3 dynamin 3 -0.00892832
EDNRA endothelin receptor type A -0.00890322
SH3PXD2B SH3 and PX domains 2B -0.00890285
KDM3A lysine (K)-specific demethylase 3A -0.00873381
TMEM39A transmembrane protein 39A -0.00870163
GAS7 growth arrest-specific 7 -0.00868755
STXBP5 syntaxin binding protein 5 (tomosyn) -0.00858283
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0085647
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.00850542
SBF2 SET binding factor 2 -0.00847052
ITPKB inositol-trisphosphate 3-kinase B -0.00840969
CSMD3 CUB and Sushi multiple domains 3 -0.00840928
MAP2K4 mitogen-activated protein kinase kinase 4 -0.00839092
PHKB phosphorylase kinase, beta -0.00833375
ZC3H15 zinc finger CCCH-type containing 15 -0.00832381
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.00814626
SPAG9 sperm associated antigen 9 -0.00813176
NEK7 NIMA-related kinase 7 -0.00811277
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0081087
ADPGK ADP-dependent glucokinase -0.0080984
NEO1 neogenin 1 -0.00808705
RAB21 RAB21, member RAS oncogene family -0.00805596
AMBRA1 autophagy/beclin-1 regulator 1 -0.00805118
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0080492