vincristine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description vincristine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the vincristine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.377941
DST dystonin 0.157471
TNNC1 troponin C type 1 (slow) 0.0990815
AKAP13 A kinase (PRKA) anchor protein 13 0.0979489
B2M beta-2-microglobulin 0.0868052
FNDC3B fibronectin type III domain containing 3B 0.0865629
MBNL2 muscleblind-like splicing regulator 2 0.0828341
MACC1 metastasis associated in colon cancer 1 0.0815268
EXT1 exostosin glycosyltransferase 1 0.0778192
MYO5B myosin VB 0.0731244
PERP PERP, TP53 apoptosis effector 0.0681632
ZBTB20 zinc finger and BTB domain containing 20 0.0616168
TRIO trio Rho guanine nucleotide exchange factor 0.0609987
FTL ferritin, light polypeptide 0.0604533
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0596549
TXNRD1 thioredoxin reductase 1 0.0591968
NTN4 netrin 4 0.0577383
MYH9 myosin, heavy chain 9, non-muscle 0.0562997
NCKAP5 NCK-associated protein 5 0.0562287
SOX4 SRY (sex determining region Y)-box 4 0.0539622
LCN2 lipocalin 2 0.053883
HKDC1 hexokinase domain containing 1 0.0533325
FRMD5 FERM domain containing 5 0.0522957
ERRFI1 ERBB receptor feedback inhibitor 1 0.0521471
EPS8 epidermal growth factor receptor pathway substrate 8 0.0511697
C6ORF132 chromosome 6 open reading frame 132 0.0507324
CXCL8 chemokine (C-X-C motif) ligand 8 0.049868
MACF1 microtubule-actin crosslinking factor 1 0.0496589
LDHA lactate dehydrogenase A 0.0488896
LPP LIM domain containing preferred translocation partner in lipoma 0.0486563
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0474232
SPRR1A small proline-rich protein 1A 0.045746
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0455363
SAMD4A sterile alpha motif domain containing 4A 0.0446731
GCLC glutamate-cysteine ligase, catalytic subunit 0.0444111
FTH1 ferritin, heavy polypeptide 1 0.0436052
S100A6 S100 calcium binding protein A6 0.0435577
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0430984
ZNF292 zinc finger protein 292 0.0411855
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0410751
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0410267
IFI27 interferon, alpha-inducible protein 27 0.0406587
CTNND1 catenin (cadherin-associated protein), delta 1 0.0403566
CLIP1 CAP-GLY domain containing linker protein 1 0.0402647
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0401668
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0388169
DIAPH1 diaphanous-related formin 1 0.0387856
KYNU kynureninase 0.038665
ACTG1 actin gamma 1 0.0373586
USP53 ubiquitin specific peptidase 53 0.0368233
CD44 CD44 molecule (Indian blood group) 0.0366484
TJP1 tight junction protein 1 0.0362731
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0344559
VEGFA vascular endothelial growth factor A 0.0343134
KLF6 Kruppel-like factor 6 0.0342377
ATXN1 ataxin 1 0.0336435
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0335895
APP amyloid beta (A4) precursor protein 0.0335292
MGLL monoglyceride lipase 0.0331583
DUSP16 dual specificity phosphatase 16 0.0324876
KRT23 keratin 23, type I 0.0324448
TXNIP thioredoxin interacting protein 0.0322309
UBC ubiquitin C 0.0321326
TACSTD2 tumor-associated calcium signal transducer 2 0.0320302
SMAD3 SMAD family member 3 0.0319299
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0316454
JMJD1C jumonji domain containing 1C 0.0307426
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0305226
CLDN4 claudin 4 0.029929
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0298668
TSC22D2 TSC22 domain family, member 2 0.028807
RNF149 ring finger protein 149 0.0285761
ANXA1 annexin A1 0.0285563
CAPN2 calpain 2, (m/II) large subunit 0.0283713
ANXA3 annexin A3 0.0282713
POTEF POTE ankyrin domain family, member F 0.0276184
TPM4 tropomyosin 4 0.0276009
SLTM SAFB-like, transcription modulator 0.0274996
KRT19 keratin 19, type I 0.0271063
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0266494
CREB5 cAMP responsive element binding protein 5 0.0265294
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0259605
UBE2H ubiquitin-conjugating enzyme E2H 0.025948
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0259021
RND3 Rho family GTPase 3 0.0255821
TMSB10 thymosin beta 10 0.0254924
NDRG1 N-myc downstream regulated 1 0.0254638
ETV6 ets variant 6 0.0252297
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0250852
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0250449
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0249942
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0248073
PELI1 pellino E3 ubiquitin protein ligase 1 0.0247928
MYH14 myosin, heavy chain 14, non-muscle 0.0242663
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0240645
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0240254
ZNFX1 zinc finger, NFX1-type containing 1 0.0239728
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0239348
MYOF myoferlin 0.02377
CEMIP2 cell migration inducing hyaluronidase 2 0.023757

decreased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 -0.117993
GMDS GDP-mannose 4,6-dehydratase -0.111855
TPT1 tumor protein, translationally-controlled 1 -0.111655
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.101362
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0980403
EPSTI1 epithelial stromal interaction 1 (breast) -0.092204
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0877027
PHF3 PHD finger protein 3 -0.0836829
EGR1 early growth response 1 -0.0807509
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0795209
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0782833
STS steroid sulfatase (microsomal), isozyme S -0.0731518
RIGI RNA sensor RIG-I -0.0709969
NPSR1 neuropeptide S receptor 1 -0.0693706
PLSCR2 phospholipid scramblase 2 -0.0633788
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0584656
LYZ lysozyme -0.0576352
PTMA prothymosin, alpha -0.0549675
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0546281
XAF1 XIAP associated factor 1 -0.0529398
MAML2 mastermind-like 2 (Drosophila) -0.0516163
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0487488
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.048342
PLSCR1 phospholipid scramblase 1 -0.0481309
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.047434
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0449971
MAP7 microtubule-associated protein 7 -0.0444804
TNS4 tensin 4 -0.0442518
JUN jun proto-oncogene -0.0439521
TM4SF19 transmembrane 4 L six family member 19 -0.0407061
EPHB2 EPH receptor B2 -0.039985
RAD51B RAD51 paralog B -0.039383
VMP1 vacuole membrane protein 1 -0.0386061
MCTP1 multiple C2 domains, transmembrane 1 -0.0384107
SP100 SP100 nuclear antigen -0.0381289
PRKCA protein kinase C, alpha -0.0373178
EZR ezrin -0.0370962
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0370479
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0365549
TM4SF1 transmembrane 4 L six family member 1 -0.0363249
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0360003
RAB7A RAB7A, member RAS oncogene family -0.0351525
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0344502
SERINC5 serine incorporator 5 -0.0342489
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0342155
LAMA4 laminin, alpha 4 -0.0340595
AHI1 Abelson helper integration site 1 -0.0339898
SQSTM1 sequestosome 1 -0.0332776
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0327239
NKD1 naked cuticle homolog 1 (Drosophila) -0.0326633
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0321464
TFRC transferrin receptor -0.0318369
ZMYND8 zinc finger, MYND-type containing 8 -0.0317612
MUC20 mucin 20, cell surface associated -0.0314678
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0312145
POU2F2 POU class 2 homeobox 2 -0.0304181
SETX senataxin -0.0299269
RABGAP1L RAB GTPase activating protein 1-like -0.0289007
FOS FBJ murine osteosarcoma viral oncogene homolog -0.028572
LOC102724023 ES1 protein homolog, mitochondrial -0.0284892
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0284384
ANXA2 annexin A2 -0.0283025
FBXO39 F-box protein 39 -0.0282071
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0279197
PMP22 peripheral myelin protein 22 -0.0276328
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0275891
MEIS2 Meis homeobox 2 -0.0273981
MBD5 methyl-CpG binding domain protein 5 -0.0273153
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0268557
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0268487
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0267286
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0267205
PDE4D phosphodiesterase 4D, cAMP-specific -0.02672
TUFT1 tuftelin 1 -0.0266182
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0264346
IER3 immediate early response 3 -0.026406
GOLGB1 golgin B1 -0.0261507
LRRC8A leucine rich repeat containing 8 family, member A -0.0259805
PATJ PATJ crumbs cell polarity complex component -0.0257132
NT5C2 5'-nucleotidase, cytosolic II -0.0255612
ERBIN erbb2 interacting protein -0.0253384
ITGA1 integrin, alpha 1 -0.0253366
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0249572
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.024875
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0248095
TOX3 TOX high mobility group box family member 3 -0.0247804
RPS24 ribosomal protein S24 -0.0246458
FHIT fragile histidine triad -0.0245963
UBAP2 ubiquitin associated protein 2 -0.0243607
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0243074
NF1 neurofibromin 1 -0.0242081
ANKRD17 ankyrin repeat domain 17 -0.023948
NCOA7 nuclear receptor coactivator 7 -0.0238771
SHB Src homology 2 domain containing adaptor protein B -0.0238092
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.023796
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0237895
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0235668
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0233766
MSI2 musashi RNA-binding protein 2 -0.0232915
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0231319