| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | vincristine perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the vincristine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.402191 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.279238 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.228996 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.223365 |
| LDHA | lactate dehydrogenase A | 0.155588 |
| COL6A3 | collagen, type VI, alpha 3 | 0.155381 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.146512 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.130902 |
| INHBA | inhibin, beta A | 0.110174 |
| MT2A | metallothionein 2A | 0.104693 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.103768 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.103298 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0981742 |
| TPM4 | tropomyosin 4 | 0.0956467 |
| CALR | calreticulin | 0.0785907 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0758892 |
| CANX | calnexin | 0.072722 |
| CALD1 | caldesmon 1 | 0.0713484 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0708423 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0685769 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0660983 |
| FBN1 | fibrillin 1 | 0.06606 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0609051 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.058918 |
| RPL3 | ribosomal protein L3 | 0.0587268 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0548223 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0543258 |
| APP | amyloid beta (A4) precursor protein | 0.0538823 |
| CALU | calumenin | 0.0519431 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0518553 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0513715 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0509335 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0502537 |
| STC1 | stanniocalcin 1 | 0.0490395 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0418038 |
| IL6 | interleukin 6 | 0.0412262 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0400221 |
| MANF | mesencephalic astrocyte-derived neurotrophic factor | 0.0389337 |
| ANXA2 | annexin A2 | 0.0388177 |
| HDAC9 | histone deacetylase 9 | 0.0380945 |
| COL3A1 | collagen, type III, alpha 1 | 0.0375263 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0374927 |
| VCL | vinculin | 0.0363925 |
| HDLBP | high density lipoprotein binding protein | 0.0361786 |
| PLEC | plectin | 0.0355774 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0351943 |
| AHNAK | AHNAK nucleoprotein | 0.0344089 |
| FLNA | filamin A, alpha | 0.0339766 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.032978 |
| SP100 | SP100 nuclear antigen | 0.0318166 |
| MT1X | metallothionein 1X | 0.031772 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.0313801 |
| UBC | ubiquitin C | 0.0307267 |
| ASPH | aspartate beta-hydroxylase | 0.0302565 |
| MYO10 | myosin X | 0.0301037 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0294339 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0287775 |
| POSTN | periostin, osteoblast specific factor | 0.0284973 |
| RUNX1 | runt-related transcription factor 1 | 0.0283743 |
| RPS4X | ribosomal protein S4, X-linked | 0.0283146 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0277689 |
| JUN | jun proto-oncogene | 0.0276568 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0275243 |
| COTL1 | coactosin-like F-actin binding protein 1 | 0.0272277 |
| PRSS23 | protease, serine, 23 | 0.027116 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0267854 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0249188 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.024585 |
| AXL | AXL receptor tyrosine kinase | 0.0244938 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0243845 |
| RASA2 | RAS p21 protein activator 2 | 0.0242413 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0239203 |
| ACTN1 | actinin, alpha 1 | 0.023774 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0237599 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0235929 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0235829 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0235056 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0233573 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0230202 |
| MSN | moesin | 0.0224187 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0223511 |
| RND3 | Rho family GTPase 3 | 0.0217797 |
| CDH13 | cadherin 13 | 0.0216979 |
| FN1 | fibronectin 1 | 0.021444 |
| TOP1 | topoisomerase (DNA) I | 0.0212452 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0211555 |
| CTSB | cathepsin B | 0.0208702 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0206964 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0206728 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0206545 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0205265 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0201556 |
| MAP1B | microtubule-associated protein 1B | 0.0201513 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.019849 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0198456 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0198326 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0197679 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.0197499 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0195953 |
| TPM1 | tropomyosin 1 (alpha) | 0.0195578 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.125479 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.101483 |
| VIM | vimentin | -0.0749205 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0739866 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.069649 |
| COL1A1 | collagen, type I, alpha 1 | -0.0660402 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0651077 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0579127 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0532101 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0460114 |
| HMGA2 | high mobility group AT-hook 2 | -0.0369411 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0358918 |
| TUBB | tubulin, beta class I | -0.0329831 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0329557 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0317674 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0312479 |
| MTSS1 | metastasis suppressor 1 | -0.0302388 |
| VCAN | versican | -0.0287698 |
| PTMA | prothymosin, alpha | -0.0285535 |
| RPL37A | ribosomal protein L37a | -0.0283835 |
| TUBA1B | tubulin, alpha 1b | -0.0272087 |
| ECE1 | endothelin converting enzyme 1 | -0.0271847 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.026425 |
| CMIP | c-Maf inducing protein | -0.0259541 |
| CADM1 | cell adhesion molecule 1 | -0.025419 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.025186 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0239686 |
| RPS2 | ribosomal protein S2 | -0.0238736 |
| IL6ST | interleukin 6 signal transducer | -0.0225407 |
| TAPBP | TAP binding protein (tapasin) | -0.0222412 |
| IER3 | immediate early response 3 | -0.0218298 |
| ATF4 | activating transcription factor 4 | -0.0213504 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0211614 |
| CD44 | CD44 molecule (Indian blood group) | -0.0210679 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0204373 |
| MTDH | metadherin | -0.0203917 |
| PDE10A | phosphodiesterase 10A | -0.0203842 |
| RPS13 | ribosomal protein S13 | -0.0202861 |
| CLTC | clathrin, heavy chain (Hc) | -0.0201984 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0200944 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0197454 |
| SBF2 | SET binding factor 2 | -0.0195463 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0193586 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0188709 |
| ATXN1 | ataxin 1 | -0.0188355 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | -0.0188297 |
| HMGA1 | high mobility group AT-hook 1 | -0.0183646 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0182638 |
| OXR1 | oxidation resistance 1 | -0.0182255 |
| MYADM | myeloid-associated differentiation marker | -0.0177542 |
| RPS27A | ribosomal protein S27a | -0.01759 |
| CNTN5 | contactin 5 | -0.0175144 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0173777 |
| CENPF | centromere protein F, 350/400kDa | -0.0171423 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0171355 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0170707 |
| RPS3 | ribosomal protein S3 | -0.0168615 |
| USP34 | ubiquitin specific peptidase 34 | -0.0163518 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0161836 |
| TUBA1C | tubulin, alpha 1c | -0.0156718 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0155639 |
| RPS29 | ribosomal protein S29 | -0.0152822 |
| RPL9 | ribosomal protein L9 | -0.0151536 |
| TUBB6 | tubulin, beta 6 class V | -0.0151199 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0149533 |
| CPQ | carboxypeptidase Q | -0.0148865 |
| SH3PXD2B | SH3 and PX domains 2B | -0.0148544 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0148344 |
| RDX | radixin | -0.0147418 |
| PDCD5 | programmed cell death 5 | -0.0147323 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0146625 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0145594 |
| CD109 | CD109 molecule | -0.0145406 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0144753 |
| UBXN4 | UBX domain protein 4 | -0.0143443 |
| STC2 | stanniocalcin 2 | -0.0142552 |
| LMNA | lamin A/C | -0.0140786 |
| PKM | pyruvate kinase, muscle | -0.0140001 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0139118 |
| S100A6 | S100 calcium binding protein A6 | -0.0136473 |
| RPL5 | ribosomal protein L5 | -0.0135534 |
| RUNX2 | runt-related transcription factor 2 | -0.0134874 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0134821 |
| PTK2 | protein tyrosine kinase 2 | -0.013402 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0133259 |
| S100A9 | S100 calcium binding protein A9 | -0.0130904 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0130586 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0127068 |
| RPL31 | ribosomal protein L31 | -0.0125379 |
| GGNBP2 | gametogenetin binding protein 2 | -0.0124284 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0124219 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.0123873 |
| CUX1 | cut-like homeobox 1 | -0.0123681 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0123632 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0123101 |
| SETD5 | SET domain containing 5 | -0.0122238 |
| SOCS5 | suppressor of cytokine signaling 5 | -0.0121555 |
| EBF1 | early B-cell factor 1 | -0.0120223 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0119957 |
| RPL35A | ribosomal protein L35a | -0.0119874 |
