vincristine_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description vincristine perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the vincristine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.30735
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.30734
IGF2 insulin-like growth factor 2 0.24229
ENO1 enolase 1, (alpha) 0.10597
ERRFI1 ERBB receptor feedback inhibitor 1 0.102276
DSPP dentin sialophosphoprotein 0.096279
LDHA lactate dehydrogenase A 0.0929941
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0779496
SAMD4A sterile alpha motif domain containing 4A 0.0700806
RPL3 ribosomal protein L3 0.0670777
SVIL supervillin 0.0662195
IGFBP1 insulin-like growth factor binding protein 1 0.0648446
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0640467
ASPH aspartate beta-hydroxylase 0.0579989
APLP2 amyloid beta (A4) precursor-like protein 2 0.0551578
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0508513
PLIN2 perilipin 2 0.0501339
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.049386
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0492561
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0479952
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0478583
FAM107B family with sequence similarity 107, member B 0.0441708
NDRG1 N-myc downstream regulated 1 0.0434854
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0429368
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0428216
TIMP1 TIMP metallopeptidase inhibitor 1 0.0419427
MT2A metallothionein 2A 0.0380906
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0380692
ATXN1 ataxin 1 0.0380133
MYH9 myosin, heavy chain 9, non-muscle 0.0351883
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0339691
EEF2 eukaryotic translation elongation factor 2 0.0339576
FRMD5 FERM domain containing 5 0.0327016
TMSB10 thymosin beta 10 0.0324245
FLNB filamin B, beta 0.0319642
KRT18 keratin 18, type I 0.031654
TPM4 tropomyosin 4 0.0309787
UBC ubiquitin C 0.0306672
RPL23 ribosomal protein L23 0.0306089
RPL37A ribosomal protein L37a 0.0304673
C3 complement component 3 0.0299143
MCL1 myeloid cell leukemia 1 0.0286168
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0285309
KYNU kynureninase 0.0278883
RPL11 ribosomal protein L11 0.0268408
EXT1 exostosin glycosyltransferase 1 0.026239
GRB10 growth factor receptor-bound protein 10 0.0259877
CANX calnexin 0.0253391
LPP LIM domain containing preferred translocation partner in lipoma 0.0253303
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0253246
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0252048
DTNA dystrobrevin, alpha 0.0239
RPS12 ribosomal protein S12 0.0238298
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0236832
ACTG1 actin gamma 1 0.0236329
EIF1 eukaryotic translation initiation factor 1 0.02268
INSIG2 insulin induced gene 2 0.022319
STC2 stanniocalcin 2 0.0219057
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0215699
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0211813
RPS17 ribosomal protein S17 0.0210876
TNS1 tensin 1 0.0210661
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0209798
PDLIM5 PDZ and LIM domain 5 0.0207824
CTSB cathepsin B 0.0207784
HMGA1 high mobility group AT-hook 1 0.0207341
MAP1B microtubule-associated protein 1B 0.0201616
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0201083
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0197153
DDIT4 DNA-damage-inducible transcript 4 0.0195017
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0194527
RPS8 ribosomal protein S8 0.0192854
RPS4X ribosomal protein S4, X-linked 0.0192292
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0191545
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0190426
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0189075
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0185992
POTEF POTE ankyrin domain family, member F 0.0184176
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.018188
ERN1 endoplasmic reticulum to nucleus signaling 1 0.017991
OPTN optineurin 0.0179278
ZBTB20 zinc finger and BTB domain containing 20 0.0178254
ITGA6 integrin, alpha 6 0.0178099
GPC6 glypican 6 0.0176788
VEGFA vascular endothelial growth factor A 0.0176593
DARS1 aspartyl-tRNA synthetase 1 0.0176067
RPL13A ribosomal protein L13a 0.0175857
SEPTIN9 septin 9 0.0172967
MACF1 microtubule-actin crosslinking factor 1 0.0171647
RNASET2 ribonuclease T2 0.0170234
RPS21 ribosomal protein S21 0.0167867
INTS6 integrator complex subunit 6 0.0166201
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0165691
RAB3B RAB3B, member RAS oncogene family 0.0163766
HM13 histocompatibility (minor) 13 0.0161144
DST dystonin 0.0160291
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0158519
FOXP1 forkhead box P1 0.0157265
GSE1 Gse1 coiled-coil protein 0.0156077
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0155141

decreased expression

Symbol Name Standardized Value
APOB apolipoprotein B -0.15977
GPC3 glypican 3 -0.0791188
NKD1 naked cuticle homolog 1 (Drosophila) -0.064364
FBF1 Fas (TNFRSF6) binding factor 1 -0.0643309
TRIM26 tripartite motif containing 26 -0.0506372
ELL2 elongation factor, RNA polymerase II, 2 -0.0486204
FNDC3B fibronectin type III domain containing 3B -0.0477197
FN1 fibronectin 1 -0.0475163
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0462181
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0436949
A2M alpha-2-macroglobulin -0.0400784
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0391638
EML4 echinoderm microtubule associated protein like 4 -0.0386643
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0346729
MBNL3 muscleblind-like splicing regulator 3 -0.0339219
RBM39 RNA binding motif protein 39 -0.0323289
VCL vinculin -0.029775
AFDN afadin, adherens junction formation factor -0.0295817
CFB complement factor B -0.0289304
MALT1 MALT1 paracaspase -0.0285754
RBM25 RNA binding motif protein 25 -0.0273715
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0268956
NRIP1 nuclear receptor interacting protein 1 -0.0253769
PTCHD4 patched domain containing 4 -0.025044
PTPRM protein tyrosine phosphatase, receptor type, M -0.0248277
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0244901
ITGAV integrin, alpha V -0.0243043
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0237882
RRBP1 ribosome binding protein 1 -0.0228789
SESTD1 SEC14 and spectrin domains 1 -0.0222814
DLC1 DLC1 Rho GTPase activating protein -0.0211467
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0206019
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0200849
ZNF644 zinc finger protein 644 -0.0198126
LYZ lysozyme -0.0197974
PTK2 protein tyrosine kinase 2 -0.019602
NFIA nuclear factor I/A -0.0190777
FCHSD2 FCH and double SH3 domains 2 -0.0188361
ARL5A ADP-ribosylation factor-like 5A -0.0184551
COBLL1 cordon-bleu WH2 repeat protein-like 1 -0.0183899
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0183278
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0182612
VMP1 vacuole membrane protein 1 -0.0179108
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.0178608
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0177383
NT5C2 5'-nucleotidase, cytosolic II -0.0177042
NCOA7 nuclear receptor coactivator 7 -0.0174203
SLC38A2 solute carrier family 38, member 2 -0.0170993
ACTN4 actinin, alpha 4 -0.0169848
TM9SF3 transmembrane 9 superfamily member 3 -0.0169124
MTUS1 microtubule associated tumor suppressor 1 -0.0167817
ARHGAP9 Rho GTPase activating protein 9 -0.0167709
POU2F1 POU class 2 homeobox 1 -0.0167607
PEG10 paternally expressed 10 -0.0167552
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0166553
FOXN3 forkhead box N3 -0.0165657
WTAP Wilms tumor 1 associated protein -0.0165096
DOCK4 dedicator of cytokinesis 4 -0.0164057
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0163435
PRRC2C proline-rich coiled-coil 2C -0.0163207
PTBP3 polypyrimidine tract binding protein 3 -0.016299
SOD2 superoxide dismutase 2, mitochondrial -0.0161251
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0160783
WDR43 WD repeat domain 43 -0.016029
TUT4 terminal uridylyl transferase 4 -0.0159163
SELENOP selenoprotein P -0.0157079
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -0.015635
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0155627
TNRC6B trinucleotide repeat containing 6B -0.0154169
LRMDA leucine rich melanocyte differentiation associated -0.0154044
PUM2 pumilio RNA-binding family member 2 -0.0153363
IGF1R insulin-like growth factor 1 receptor -0.0152899
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0150188
CHD6 chromodomain helicase DNA binding protein 6 -0.0148416
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0146553
ZEB1 zinc finger E-box binding homeobox 1 -0.0145511
MSI2 musashi RNA-binding protein 2 -0.0143601
MAPK8 mitogen-activated protein kinase 8 -0.0143587
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0141082
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0140433
SYNJ2 synaptojanin 2 -0.0139852
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0139564
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0138229
MATR3 matrin 3 -0.0138108
PHF3 PHD finger protein 3 -0.0136678
LCOR ligand dependent nuclear receptor corepressor -0.013622
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.013582
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0135472
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0135043
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0133448
HLF hepatic leukemia factor -0.0133279
CADM1 cell adhesion molecule 1 -0.0132785
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.013183
NPEPPS aminopeptidase puromycin sensitive -0.013156
NIPBL Nipped-B homolog (Drosophila) -0.0130081
RAD21 RAD21 homolog (S. pombe) -0.0128432
WAC WW domain containing adaptor with coiled-coil -0.0128398
MBD5 methyl-CpG binding domain protein 5 -0.0128258
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0126144
TLK1 tousled-like kinase 1 -0.0125711