vincristine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description vincristine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the vincristine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.117786
PALM2AKAP2 PALM2 and AKAP2 fusion 0.092126
DOCK5 dedicator of cytokinesis 5 0.0745795
MYH9 myosin, heavy chain 9, non-muscle 0.0663667
MYOF myoferlin 0.063218
LDHA lactate dehydrogenase A 0.0616597
AHNAK AHNAK nucleoprotein 0.0525451
DPYD dihydropyrimidine dehydrogenase 0.0456047
LMO7 LIM domain 7 0.044819
PODXL podocalyxin-like 0.0446439
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0410921
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0409801
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0408308
ASPH aspartate beta-hydroxylase 0.040099
ARHGAP29 Rho GTPase activating protein 29 0.0400801
CEMIP cell migration inducing protein, hyaluronan binding 0.0394576
PLAT plasminogen activator, tissue 0.0390085
TOP1 topoisomerase (DNA) I 0.0384212
CMIP c-Maf inducing protein 0.0381087
PRSS23 protease, serine, 23 0.0380939
KRT17 keratin 17, type I 0.0379996
DPYSL2 dihydropyrimidinase-like 2 0.0379261
PLEC plectin 0.0379152
DUSP4 dual specificity phosphatase 4 0.0372668
BLCAP bladder cancer associated protein 0.0368503
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0368378
CDK6 cyclin-dependent kinase 6 0.0361793
DST dystonin 0.0358702
SRRM2 serine/arginine repetitive matrix 2 0.0348677
MSN moesin 0.0348642
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0346098
POTEF POTE ankyrin domain family, member F 0.034482
NRG1 neuregulin 1 0.0339709
SULF1 sulfatase 1 0.0334092
TRIO trio Rho guanine nucleotide exchange factor 0.0328927
HMGA2 high mobility group AT-hook 2 0.0328114
F3 coagulation factor III (thromboplastin, tissue factor) 0.0327796
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.032423
MYO10 myosin X 0.0319842
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0312518
BCL2L1 BCL2-like 1 0.030713
PLXNA2 plexin A2 0.0295355
OSMR oncostatin M receptor 0.0292764
MKI67 marker of proliferation Ki-67 0.0289184
ITGA6 integrin, alpha 6 0.0285706
SLC38A2 solute carrier family 38, member 2 0.0285427
PDLIM5 PDZ and LIM domain 5 0.0283803
NEK7 NIMA-related kinase 7 0.0282142
RIN2 Ras and Rab interactor 2 0.0281165
RPS19 ribosomal protein S19 0.027916
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0272816
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0270368
RASAL2 RAS protein activator like 2 0.0269747
TPM3 tropomyosin 3 0.0267008
UTRN utrophin 0.026617
PLS3 plastin 3 0.026613
AMOTL1 angiomotin like 1 0.0265086
SMAD3 SMAD family member 3 0.0264735
FOXO1 forkhead box O1 0.0259816
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0258508
CAPRIN2 caprin family member 2 0.0256163
RPL3 ribosomal protein L3 0.0251786
ACTN4 actinin, alpha 4 0.0248978
SULF2 sulfatase 2 0.0247763
CALB1 calbindin 1, 28kDa 0.0246719
ENO1 enolase 1, (alpha) 0.0245852
SAMD9 sterile alpha motif domain containing 9 0.0245204
CD44 CD44 molecule (Indian blood group) 0.0235515
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0232193
TMSB4X thymosin beta 4, X-linked 0.0229438
TXNRD1 thioredoxin reductase 1 0.0228899
MPRIP myosin phosphatase Rho interacting protein 0.0227166
ANKRD28 ankyrin repeat domain 28 0.0222442
SVIL supervillin 0.0222254
JAG1 jagged 1 0.0221798
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0220878
FNDC3B fibronectin type III domain containing 3B 0.0219383
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0215762
ACTG1 actin gamma 1 0.0214966
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0213249
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0211395
HSPA8 heat shock 70kDa protein 8 0.0211008
FLNA filamin A, alpha 0.020971
AKAP13 A kinase (PRKA) anchor protein 13 0.0208311
CAV1 caveolin 1, caveolae protein, 22kDa 0.0206247
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0205932
TPM4 tropomyosin 4 0.020591
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.02044
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0203615
RRBP1 ribosome binding protein 1 0.0203183
AHNAK2 AHNAK nucleoprotein 2 0.020263
ANKRD33B ankyrin repeat domain 33B 0.0202583
RPL5 ribosomal protein L5 0.0201969
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0201359
CPNE1 copine I 0.0201348
ANO1 anoctamin 1, calcium activated chloride channel 0.0199693
EFNA5 ephrin-A5 0.0199426
KIAA0040 KIAA0040 0.0198379
FAM107B family with sequence similarity 107, member B 0.019815
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.019653

decreased expression

Symbol Name Standardized Value
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0613978
PTMA prothymosin, alpha -0.0495543
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0458683
MEF2A myocyte enhancer factor 2A -0.0424341
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0413479
PGK1 phosphoglycerate kinase 1 -0.0401669
ANXA1 annexin A1 -0.0367259
RPS24 ribosomal protein S24 -0.0362684
FTL ferritin, light polypeptide -0.0348934
B2M beta-2-microglobulin -0.0310617
S100A9 S100 calcium binding protein A9 -0.030804
ITCH itchy E3 ubiquitin protein ligase -0.0290993
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0287773
MTSS1 metastasis suppressor 1 -0.0271398
RPL35A ribosomal protein L35a -0.0261548
LMNA lamin A/C -0.025488
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.024967
MT2A metallothionein 2A -0.0244817
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0244008
GUK1 guanylate kinase 1 -0.024222
TPT1 tumor protein, translationally-controlled 1 -0.024177
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.023949
CDK13 cyclin-dependent kinase 13 -0.023908
VDAC1 voltage-dependent anion channel 1 -0.0228869
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0224625
GNAS GNAS complex locus -0.0224332
SQLE squalene epoxidase -0.0224067
DSTN destrin (actin depolymerizing factor) -0.0223455
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0215019
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0214179
S100A6 S100 calcium binding protein A6 -0.0213048
IFITM1 interferon induced transmembrane protein 1 -0.0206849
TUBB4B tubulin, beta 4B class IVb -0.0205423
KDM3A lysine (K)-specific demethylase 3A -0.0204305
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0199186
COG5 component of oligomeric golgi complex 5 -0.0196983
PDE4D phosphodiesterase 4D, cAMP-specific -0.0196817
HSPG2 heparan sulfate proteoglycan 2 -0.0196017
RBM39 RNA binding motif protein 39 -0.0195659
NAMPT nicotinamide phosphoribosyltransferase -0.0193956
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.019337
MARCHF6 membrane associated ring-CH-type finger 6 -0.0192738
RPS29 ribosomal protein S29 -0.0186916
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0184052
KDM5B lysine (K)-specific demethylase 5B -0.0182316
FSCN1 fascin actin-bundling protein 1 -0.0178884
RPS25 ribosomal protein S25 -0.0176299
HLA-E major histocompatibility complex, class I, E -0.0174795
HMGA1 high mobility group AT-hook 1 -0.0174208
ESYT2 extended synaptotagmin-like protein 2 -0.0173436
WNK1 WNK lysine deficient protein kinase 1 -0.0170265
WASF2 WAS protein family, member 2 -0.0168018
TUBB tubulin, beta class I -0.0166561
RPS16 ribosomal protein S16 -0.0166531
MDK midkine (neurite growth-promoting factor 2) -0.0165343
IGF2 insulin-like growth factor 2 -0.0164799
RPS11 ribosomal protein S11 -0.0164734
RPS27A ribosomal protein S27a -0.0163649
IER3 immediate early response 3 -0.0163227
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0162522
HLA-A major histocompatibility complex, class I, A -0.0161684
COPB1 coatomer protein complex, subunit beta 1 -0.0161647
GRB10 growth factor receptor-bound protein 10 -0.0161323
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.015601
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -0.0155964
KIAA1217 KIAA1217 -0.0154317
RPLP2 ribosomal protein, large, P2 -0.015255
IFRD1 interferon-related developmental regulator 1 -0.0152387
CLU clusterin -0.015139
RPL37A ribosomal protein L37a -0.0150367
MBNL2 muscleblind-like splicing regulator 2 -0.0148731
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0148202
AKAP12 A kinase (PRKA) anchor protein 12 -0.014813
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0146099
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0143628
RPS2 ribosomal protein S2 -0.0142473
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0141885
RPS21 ribosomal protein S21 -0.0140757
SRPK2 SRSF protein kinase 2 -0.0139967
RAP1B RAP1B, member of RAS oncogene family -0.0139593
ZMYM2 zinc finger, MYM-type 2 -0.0138347
TFG TRK-fused gene -0.0134765
ABI3BP ABI family, member 3 (NESH) binding protein -0.0133998
RLF rearranged L-myc fusion -0.0133898
RAI14 retinoic acid induced 14 -0.013322
CLTC clathrin, heavy chain (Hc) -0.0133063
KDM4C lysine (K)-specific demethylase 4C -0.0132341
WSB1 WD repeat and SOCS box containing 1 -0.0132188
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0131713
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0131707
RPL36A ribosomal protein L36a -0.0130938
RPL23 ribosomal protein L23 -0.0130501
ADM adrenomedullin -0.0130316
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0130096
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0129407
ANLN anillin, actin binding protein -0.0128598
RPS13 ribosomal protein S13 -0.0128094
WARS1 tryptophanyl-tRNA synthetase 1 -0.012784
OGA O-GlcNAcase -0.0127657
MON2 MON2 homolog (S. cerevisiae) -0.012636