vincristine_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description vincristine perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the vincristine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.303163
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.143335
MT2A metallothionein 2A 0.116742
LDHA lactate dehydrogenase A 0.114945
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.114405
KRT18 keratin 18, type I 0.106337
TMSB10 thymosin beta 10 0.0788001
ERRFI1 ERBB receptor feedback inhibitor 1 0.0688572
MYOF myoferlin 0.0598936
PDLIM5 PDZ and LIM domain 5 0.0589037
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0568836
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0535982
HSPA8 heat shock 70kDa protein 8 0.0528809
SCEL sciellin 0.0521172
SEC61G Sec61 gamma subunit 0.0505161
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0497576
KRT7 keratin 7, type II 0.0491239
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0490696
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0479637
SRRM2 serine/arginine repetitive matrix 2 0.0470984
MSN moesin 0.0446576
HDLBP high density lipoprotein binding protein 0.0431869
CXCL8 chemokine (C-X-C motif) ligand 8 0.0422809
THSD4 thrombospondin, type I, domain containing 4 0.0387352
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0382419
ANXA3 annexin A3 0.0381088
AKAP12 A kinase (PRKA) anchor protein 12 0.0378197
RPL3 ribosomal protein L3 0.0368555
INTS6 integrator complex subunit 6 0.0368064
MAGEA4 melanoma antigen family A4 0.0355012
BCAR3 breast cancer anti-estrogen resistance 3 0.03534
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0347825
RPS4X ribosomal protein S4, X-linked 0.0340438
TPM3 tropomyosin 3 0.0332436
SMYD3 SET and MYND domain containing 3 0.0331948
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.0330155
ACTN1 actinin, alpha 1 0.0328906
CMIP c-Maf inducing protein 0.0327906
PLEC plectin 0.0319859
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0315249
CTBP2 C-terminal binding protein 2 0.0312385
CSNK1E casein kinase 1, epsilon 0.030228
ATP11A ATPase, class VI, type 11A 0.0296228
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.02958
YBX3 Y box binding protein 3 0.029314
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0292269
TPM4 tropomyosin 4 0.0287576
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0282021
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0278788
RPL8 ribosomal protein L8 0.0278663
NABP1 nucleic acid binding protein 1 0.0278158
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.027439
APLP2 amyloid beta (A4) precursor-like protein 2 0.027299
SLTM SAFB-like, transcription modulator 0.027252
RPLP1 ribosomal protein, large, P1 0.0268589
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0265207
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0263725
NTSR1 neurotensin receptor 1 (high affinity) 0.0261547
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0259619
MYH9 myosin, heavy chain 9, non-muscle 0.0257606
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0255425
HYOU1 hypoxia up-regulated 1 0.0254885
CUL4A cullin 4A 0.0253329
TPI1 triosephosphate isomerase 1 0.0245639
RBBP6 retinoblastoma binding protein 6 0.0243804
SERBP1 SERPINE1 mRNA binding protein 1 0.0243054
MBNL1 muscleblind-like splicing regulator 1 0.0242666
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0240491
PTK2 protein tyrosine kinase 2 0.0239874
LRP12 low density lipoprotein receptor-related protein 12 0.0239049
ITGA6 integrin, alpha 6 0.0238656
FOSL1 FOS-like antigen 1 0.023818
SAMD4A sterile alpha motif domain containing 4A 0.0238004
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0237468
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0235819
RPL7 ribosomal protein L7 0.0235256
CANX calnexin 0.0233798
SLC38A2 solute carrier family 38, member 2 0.0232382
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0230116
RPL19 ribosomal protein L19 0.0227586
MCL1 myeloid cell leukemia 1 0.0226266
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0225925
EZR ezrin 0.0225531
EIF5B eukaryotic translation initiation factor 5B 0.0223373
LDHB lactate dehydrogenase B 0.0221985
TTC3 tetratricopeptide repeat domain 3 0.0219085
RPL12 ribosomal protein L12 0.0216721
CD163L1 CD163 molecule-like 1 0.0216125
DIAPH1 diaphanous-related formin 1 0.0215963
IFI6 interferon, alpha-inducible protein 6 0.0215348
CD99 CD99 molecule 0.0210254
PFN1 profilin 1 0.0206775
CLMB calcimembrin 0.0206333
ADAR adenosine deaminase, RNA-specific 0.0205905
MACF1 microtubule-actin crosslinking factor 1 0.0204537
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0204424
SON SON DNA binding protein 0.0203856
PNN pinin, desmosome associated protein 0.0203507
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0203348
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0202565

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.126483
LRP1B low density lipoprotein receptor-related protein 1B -0.0721341
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0577698
NAMPT nicotinamide phosphoribosyltransferase -0.0561955
NDRG1 N-myc downstream regulated 1 -0.0527913
PDE4D phosphodiesterase 4D, cAMP-specific -0.0508187
RPS27A ribosomal protein S27a -0.0478341
GSK3B glycogen synthase kinase 3 beta -0.0476449
OSMR oncostatin M receptor -0.045176
ZMYND8 zinc finger, MYND-type containing 8 -0.0428735
TPT1 tumor protein, translationally-controlled 1 -0.0414112
ACTG1 actin gamma 1 -0.0410274
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0392234
H1-0 H1.0 linker histone -0.0337985
RAB27B RAB27B, member RAS oncogene family -0.0335594
FTL ferritin, light polypeptide -0.0322866
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0319414
LAMC2 laminin, gamma 2 -0.031373
FNDC3B fibronectin type III domain containing 3B -0.0311879
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.030649
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0304638
SOD2 superoxide dismutase 2, mitochondrial -0.0303611
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0301346
UBC ubiquitin C -0.0298362
RPS24 ribosomal protein S24 -0.0293771
TXNRD1 thioredoxin reductase 1 -0.0288815
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0284979
LMO7 LIM domain 7 -0.0279823
RPL35A ribosomal protein L35a -0.0279733
BIRC6 baculoviral IAP repeat containing 6 -0.0277634
LOC102724023 ES1 protein homolog, mitochondrial -0.02736
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0271371
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0270675
ZMYM2 zinc finger, MYM-type 2 -0.0264511
RAB1A RAB1A, member RAS oncogene family -0.0264439
PGK1 phosphoglycerate kinase 1 -0.0262733
PTPRM protein tyrosine phosphatase, receptor type, M -0.0261447
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.026028
ARHGAP32 Rho GTPase activating protein 32 -0.0259057
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0257949
KDM2A lysine (K)-specific demethylase 2A -0.0257363
RPL38 ribosomal protein L38 -0.0254642
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0251672
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0248582
ASPH aspartate beta-hydroxylase -0.0247325
PKM pyruvate kinase, muscle -0.0243717
SLC38A1 solute carrier family 38, member 1 -0.024204
RPL31 ribosomal protein L31 -0.0240585
KPNB1 karyopherin (importin) beta 1 -0.0238646
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0238619
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0235238
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.023489
SEC31A SEC31 homolog A (S. cerevisiae) -0.0232393
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.023189
CAMTA1 calmodulin binding transcription activator 1 -0.0229051
CDK13 cyclin-dependent kinase 13 -0.0228564
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0228314
DENND4A DENN/MADD domain containing 4A -0.0227657
ANKRD12 ankyrin repeat domain 12 -0.0226235
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0221538
MGAT4C MGAT4 family, member C -0.0220495
CAV1 caveolin 1, caveolae protein, 22kDa -0.0220113
RAB6A RAB6A, member RAS oncogene family -0.0218112
GPC6 glypican 6 -0.0217109
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0210654
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0207429
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0203809
NF1 neurofibromin 1 -0.0203543
RYBP RING1 and YY1 binding protein -0.0203213
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0203153
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0201973
GPC5 glypican 5 -0.0201137
IQGAP1 IQ motif containing GTPase activating protein 1 -0.019991
UVRAG UV radiation resistance associated -0.0199176
BRWD3 bromodomain and WD repeat domain containing 3 -0.0197561
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0194623
ELL2 elongation factor, RNA polymerase II, 2 -0.0192933
NGLY1 N-glycanase 1 -0.0191689
NPEPPS aminopeptidase puromycin sensitive -0.0185812
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0181871
RPL26 ribosomal protein L26 -0.0181788
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0181377
EP300 E1A binding protein p300 -0.0180919
KDM3A lysine (K)-specific demethylase 3A -0.0180799
USP34 ubiquitin specific peptidase 34 -0.0179631
CTNND1 catenin (cadherin-associated protein), delta 1 -0.017839
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0177528
YEATS2 YEATS domain containing 2 -0.0177096
KCMF1 potassium channel modulatory factor 1 -0.0176457
JAK1 Janus kinase 1 -0.0175642
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0175636
HOOK2 hook microtubule-tethering protein 2 -0.0174705
FBXO34 F-box protein 34 -0.017464
ANKRD10 ankyrin repeat domain 10 -0.0173961
GCLC glutamate-cysteine ligase, catalytic subunit -0.017353
TRIO trio Rho guanine nucleotide exchange factor -0.017339
CAVIN1 caveolae associated protein 1 -0.0172409
BRWD1 bromodomain and WD repeat domain containing 1 -0.0172283
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0172247
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0171715