vincristine_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description vincristine perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the vincristine_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0957128
SMAD3 SMAD family member 3 0.0863097
CD44 CD44 molecule (Indian blood group) 0.0740971
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0721017
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0613043
SOD2 superoxide dismutase 2, mitochondrial 0.0605777
LDHA lactate dehydrogenase A 0.0570123
PCBP2 poly(rC) binding protein 2 0.0533014
NAV2 neuron navigator 2 0.0488957
RICTOR RPTOR independent companion of MTOR, complex 2 0.048405
ELL2 elongation factor, RNA polymerase II, 2 0.0478923
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.047659
GRB10 growth factor receptor-bound protein 10 0.0470545
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.042927
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.042423
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0413074
DOCK5 dedicator of cytokinesis 5 0.0378341
LOXL2 lysyl oxidase-like 2 0.0362953
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0356682
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0353685
MYH9 myosin, heavy chain 9, non-muscle 0.0352326
MYO10 myosin X 0.0349237
FNDC3B fibronectin type III domain containing 3B 0.0344499
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0336514
RBM39 RNA binding motif protein 39 0.0335127
KDM2A lysine (K)-specific demethylase 2A 0.032642
ZEB2 zinc finger E-box binding homeobox 2 0.0325616
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.03224
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0318933
FAM107B family with sequence similarity 107, member B 0.0317618
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0316804
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0315874
FAM13A family with sequence similarity 13, member A 0.030265
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0301606
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0299705
FAM20C family with sequence similarity 20, member C 0.0281504
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0278674
GOLGA4 golgin A4 0.0267848
PARP14 poly (ADP-ribose) polymerase family, member 14 0.026572
RPL3 ribosomal protein L3 0.0259773
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0253617
NPC1 Niemann-Pick disease, type C1 0.0252241
TOP1 topoisomerase (DNA) I 0.0252237
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0247806
APP amyloid beta (A4) precursor protein 0.024726
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0241221
SEPTIN9 septin 9 0.0238541
PFKP phosphofructokinase, platelet 0.0234636
RUNX1 runt-related transcription factor 1 0.0232922
TRIO trio Rho guanine nucleotide exchange factor 0.023226
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0230691
FBXL13 F-box and leucine-rich repeat protein 13 0.023042
ADD3 adducin 3 (gamma) 0.0228937
APLP2 amyloid beta (A4) precursor-like protein 2 0.0227172
SIK3 SIK family kinase 3 0.022714
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0226424
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0224401
RAB1A RAB1A, member RAS oncogene family 0.0224131
ZC3H12C zinc finger CCCH-type containing 12C 0.0223255
COL7A1 collagen, type VII, alpha 1 0.0219737
EGFR epidermal growth factor receptor 0.0217827
BIRC3 baculoviral IAP repeat containing 3 0.0213839
TPST1 tyrosylprotein sulfotransferase 1 0.0204962
JARID2 jumonji, AT rich interactive domain 2 0.0204889
DSCAM Down syndrome cell adhesion molecule 0.0201517
SEC24A SEC24 family member A 0.0201279
TGM2 transglutaminase 2 0.019756
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0193864
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0193192
COPA coatomer protein complex, subunit alpha 0.0192861
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0190013
ICAM1 intercellular adhesion molecule 1 0.0188384
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0187829
PRELID2 PRELI domain containing 2 0.0186183
BASP1 brain abundant, membrane attached signal protein 1 0.0184716
ESYT2 extended synaptotagmin-like protein 2 0.01841
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0182184
ECE1 endothelin converting enzyme 1 0.0180496
RND3 Rho family GTPase 3 0.0179866
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.017951
BACE2 beta-site APP-cleaving enzyme 2 0.0179272
AMPD3 adenosine monophosphate deaminase 3 0.0179012
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0175711
PLEC plectin 0.0175186
AKAP9 A kinase (PRKA) anchor protein 9 0.0172816
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0172203
HDLBP high density lipoprotein binding protein 0.0171957
CTNND1 catenin (cadherin-associated protein), delta 1 0.016898
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0168406
SEC23A Sec23 homolog A (S. cerevisiae) 0.0166932
ANKRD36 ankyrin repeat domain 36 0.0164901
FLNB filamin B, beta 0.0164789
SYAP1 synapse associated protein 1 0.0164387
MCL1 myeloid cell leukemia 1 0.0163173
PTPRM protein tyrosine phosphatase, receptor type, M 0.0162571
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0161523
EIF4H eukaryotic translation initiation factor 4H 0.0159528
CALU calumenin 0.0159031
SNX9 sorting nexin 9 0.0158318
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0158262

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.156721
TMSB10 thymosin beta 10 -0.130704
FN1 fibronectin 1 -0.0967518
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0766681
RPL35A ribosomal protein L35a -0.0596172
RPS19 ribosomal protein S19 -0.0556961
RPL37A ribosomal protein L37a -0.0544268
RPL31 ribosomal protein L31 -0.0534164
RPS8 ribosomal protein S8 -0.0515923
FTL ferritin, light polypeptide -0.0501664
RPLP1 ribosomal protein, large, P1 -0.0480609
RPS6 ribosomal protein S6 -0.0472405
MT2A metallothionein 2A -0.044068
PSD3 pleckstrin and Sec7 domain containing 3 -0.0439133
NDRG1 N-myc downstream regulated 1 -0.0438873
RPS29 ribosomal protein S29 -0.0437534
GPC6 glypican 6 -0.0428886
CDH13 cadherin 13 -0.0413446
RPS13 ribosomal protein S13 -0.0409231
EIF1 eukaryotic translation initiation factor 1 -0.0391822
PTMA prothymosin, alpha -0.0389408
DST dystonin -0.0387442
RPL36 ribosomal protein L36 -0.0379998
HMGA1 high mobility group AT-hook 1 -0.0372359
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.036773
STC1 stanniocalcin 1 -0.0365266
RPS21 ribosomal protein S21 -0.0361553
RPL11 ribosomal protein L11 -0.0360159
DPYD dihydropyrimidine dehydrogenase -0.035728
NRG1 neuregulin 1 -0.0341368
RPL28 ribosomal protein L28 -0.0339998
RPS17 ribosomal protein S17 -0.0332588
RPL5 ribosomal protein L5 -0.0322708
RPS3 ribosomal protein S3 -0.0311187
DLG1 discs, large homolog 1 (Drosophila) -0.0307303
TIMP3 TIMP metallopeptidase inhibitor 3 -0.030332
RPS23 ribosomal protein S23 -0.0299372
EGR1 early growth response 1 -0.0297995
ACTG1 actin gamma 1 -0.0295203
SDK1 sidekick cell adhesion molecule 1 -0.0290066
LOX lysyl oxidase -0.028535
S100A6 S100 calcium binding protein A6 -0.0274608
POTEF POTE ankyrin domain family, member F -0.0271134
RPS11 ribosomal protein S11 -0.0268784
RPL9 ribosomal protein L9 -0.0264849
RPL23 ribosomal protein L23 -0.0259142
RPL38 ribosomal protein L38 -0.0259127
RPS16 ribosomal protein S16 -0.0252375
RPS25 ribosomal protein S25 -0.0251675
RPL34 ribosomal protein L34 -0.0250697
TFPI2 tissue factor pathway inhibitor 2 -0.0248614
RPLP2 ribosomal protein, large, P2 -0.0248449
LOC102724023 ES1 protein homolog, mitochondrial -0.0245176
PDE4D phosphodiesterase 4D, cAMP-specific -0.0242894
MECOM MDS1 and EVI1 complex locus -0.0242705
RPL7A ribosomal protein L7a -0.0238668
RPS5 ribosomal protein S5 -0.0237967
IFI27 interferon, alpha-inducible protein 27 -0.0237433
ENO2 enolase 2 (gamma, neuronal) -0.0236512
RPS24 ribosomal protein S24 -0.0235433
RPS27 ribosomal protein S27 -0.0232029
PKM pyruvate kinase, muscle -0.0226923
B2M beta-2-microglobulin -0.0225314
RPS10 ribosomal protein S10 -0.0223422
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -0.0222419
RACK1 receptor for activated C kinase 1 -0.0214685
RPS12 ribosomal protein S12 -0.0212927
TM4SF1 transmembrane 4 L six family member 1 -0.020838
RPS27A ribosomal protein S27a -0.0207917
RPL19 ribosomal protein L19 -0.0207119
RPL12 ribosomal protein L12 -0.0206871
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0202371
ZNF804A zinc finger protein 804A -0.0202244
RPL32 ribosomal protein L32 -0.0199524
MAML3 mastermind-like 3 (Drosophila) -0.0198725
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.019799
RPL26 ribosomal protein L26 -0.0191456
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0191292
RPL37 ribosomal protein L37 -0.0189005
PRRC2C proline-rich coiled-coil 2C -0.0184166
SYT1 synaptotagmin I -0.0182593
RPS14 ribosomal protein S14 -0.0180907
TMSB4X thymosin beta 4, X-linked -0.0177999
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0176216
S100A9 S100 calcium binding protein A9 -0.0174764
MEF2A myocyte enhancer factor 2A -0.0173263
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0171928
TPT1 tumor protein, translationally-controlled 1 -0.0170734
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0170063
S100A11 S100 calcium binding protein A11 -0.0169803
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0169787
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.016861
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0168442
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0167295
RPL13A ribosomal protein L13a -0.0163888
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0162084
RPS15 ribosomal protein S15 -0.0160637
LOC112694756 uncharaterized LOC112694756 -0.0158004
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0157981
IER3 immediate early response 3 -0.0157179