vincristine_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description vincristine perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the vincristine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.313441
AKAP12 A kinase (PRKA) anchor protein 12 0.230428
TXNRD1 thioredoxin reductase 1 0.196175
LMO7 LIM domain 7 0.19239
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.174889
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.155427
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0970711
BACE2 beta-site APP-cleaving enzyme 2 0.0945207
KYNU kynureninase 0.0909244
DSCAM Down syndrome cell adhesion molecule 0.084234
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0789109
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0785732
JMJD1C jumonji domain containing 1C 0.0782851
BIRC6 baculoviral IAP repeat containing 6 0.0766746
LDHA lactate dehydrogenase A 0.0760883
TNPO1 transportin 1 0.0740115
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0727879
SLK STE20-like kinase 0.0712538
TJP1 tight junction protein 1 0.0648714
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0628868
MTUS1 microtubule associated tumor suppressor 1 0.0621125
JARID2 jumonji, AT rich interactive domain 2 0.0606599
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0591399
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0574897
EEF2 eukaryotic translation elongation factor 2 0.056445
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0558013
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0550662
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0536632
MYO6 myosin VI 0.0530229
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0527772
BTBD9 BTB (POZ) domain containing 9 0.0523618
MYOF myoferlin 0.0523164
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0513227
UBE2H ubiquitin-conjugating enzyme E2H 0.050621
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0487092
NCOA3 nuclear receptor coactivator 3 0.048232
RPS8 ribosomal protein S8 0.0466533
KATNBL1 katanin p80 subunit B-like 1 0.0463342
IGF1R insulin-like growth factor 1 receptor 0.0462349
DST dystonin 0.0455772
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0455481
RPLP1 ribosomal protein, large, P1 0.0448791
NIPBL Nipped-B homolog (Drosophila) 0.0430903
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0427489
PTK2 protein tyrosine kinase 2 0.0426073
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.042065
AHNAK AHNAK nucleoprotein 0.0415349
TOP1 topoisomerase (DNA) I 0.0408831
SRSF11 serine/arginine-rich splicing factor 11 0.0406453
USP15 ubiquitin specific peptidase 15 0.0405316
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0392558
SNX9 sorting nexin 9 0.0387929
TPT1 tumor protein, translationally-controlled 1 0.0387695
FLNB filamin B, beta 0.0386358
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0385213
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0361737
S100A6 S100 calcium binding protein A6 0.036168
SEPTIN9 septin 9 0.0360967
VIM vimentin 0.0359504
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0359209
FLNA filamin A, alpha 0.0358642
RPS24 ribosomal protein S24 0.0358222
BRD4 bromodomain containing 4 0.0357738
CAB39 calcium binding protein 39 0.0356688
EIF1 eukaryotic translation initiation factor 1 0.0353253
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0352947
CXCL8 chemokine (C-X-C motif) ligand 8 0.0344989
GPHN gephyrin 0.0339165
OGA O-GlcNAcase 0.0336972
DSPP dentin sialophosphoprotein 0.0336171
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0314096
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0312348
CANX calnexin 0.0311977
RPS12 ribosomal protein S12 0.0311757
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0306619
PIAS1 protein inhibitor of activated STAT, 1 0.0297657
MT2A metallothionein 2A 0.0296407
RPS19 ribosomal protein S19 0.0295918
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0295357
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.028771
ZMYM2 zinc finger, MYM-type 2 0.0281279
NPEPPS aminopeptidase puromycin sensitive 0.0278754
RPL19 ribosomal protein L19 0.0277949
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0277441
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0275594
RPS13 ribosomal protein S13 0.0274607
EGFR epidermal growth factor receptor 0.0272325
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0269242
GOLGA4 golgin A4 0.0263304
TTC3 tetratricopeptide repeat domain 3 0.0262304
MED13L mediator complex subunit 13-like 0.0261426
SOS1 son of sevenless homolog 1 (Drosophila) 0.0261277
RPS4X ribosomal protein S4, X-linked 0.026079
PDIA6 protein disulfide isomerase family A, member 6 0.0252806
NABP1 nucleic acid binding protein 1 0.0250275
RPS3 ribosomal protein S3 0.0246971
EZR ezrin 0.0243006
RBM33 RNA binding motif protein 33 0.024173
THSD4 thrombospondin, type I, domain containing 4 0.0241068
RPLP0 ribosomal protein, large, P0 0.0237883

decreased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 -0.215505
CEMIP cell migration inducing protein, hyaluronan binding -0.168381
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.136735
PDE4D phosphodiesterase 4D, cAMP-specific -0.118694
SAMD4A sterile alpha motif domain containing 4A -0.113828
LAMB3 laminin, beta 3 -0.0951193
NALF1 NALCN channel auxiliary factor 1 -0.0944665
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0887971
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0815785
MAML2 mastermind-like 2 (Drosophila) -0.0804408
MXD1 MAX dimerization protein 1 -0.0787371
ADGRB3 adhesion G protein-coupled receptor B3 -0.0776973
PLAUR plasminogen activator, urokinase receptor -0.0772296
WSB1 WD repeat and SOCS box containing 1 -0.0767404
COL6A3 collagen, type VI, alpha 3 -0.075697
MAML3 mastermind-like 3 (Drosophila) -0.0735178
FAM13A family with sequence similarity 13, member A -0.0718693
RORA RAR-related orphan receptor A -0.0678445
MMP1 matrix metallopeptidase 1 -0.0673251
LAMC2 laminin, gamma 2 -0.0672738
PICALM phosphatidylinositol binding clathrin assembly protein -0.0662324
IGFBP3 insulin-like growth factor binding protein 3 -0.0660909
ABI3BP ABI family, member 3 (NESH) binding protein -0.0654794
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0641895
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0640435
ARHGAP32 Rho GTPase activating protein 32 -0.0634543
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0633293
PTPRM protein tyrosine phosphatase, receptor type, M -0.063231
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0579417
MYO1E myosin IE -0.0557949
EHBP1 EH domain binding protein 1 -0.0513939
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0507635
ZNF638 zinc finger protein 638 -0.0492864
PRKCA protein kinase C, alpha -0.0487004
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0475941
RIGI RNA sensor RIG-I -0.0467006
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0460656
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0454485
MEF2A myocyte enhancer factor 2A -0.0447024
GLS2 glutaminase 2 (liver, mitochondrial) -0.044294
ANKRD12 ankyrin repeat domain 12 -0.044202
ATP13A3 ATPase type 13A3 -0.0438693
PDLIM5 PDZ and LIM domain 5 -0.0435724
NAMPT nicotinamide phosphoribosyltransferase -0.043419
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0434041
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.043129
TSC22D2 TSC22 domain family, member 2 -0.0426724
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.042667
CLINT1 clathrin interactor 1 -0.0425094
ZBTB20 zinc finger and BTB domain containing 20 -0.0423854
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0422284
ARHGAP26 Rho GTPase activating protein 26 -0.0417038
SOX4 SRY (sex determining region Y)-box 4 -0.0411947
MAP4 microtubule-associated protein 4 -0.0408858
RUNX1 runt-related transcription factor 1 -0.0403507
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0401369
SMAD3 SMAD family member 3 -0.0391571
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0388682
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0386277
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0386131
BRWD1 bromodomain and WD repeat domain containing 1 -0.0385801
TRIP12 thyroid hormone receptor interactor 12 -0.0383777
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0376969
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.037662
SPAG9 sperm associated antigen 9 -0.0368398
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0367976
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.03659
CDH13 cadherin 13 -0.0357584
LIMCH1 LIM and calponin homology domains 1 -0.0357019
EFNA5 ephrin-A5 -0.0349991
TRIO trio Rho guanine nucleotide exchange factor -0.0329493
ELL2 elongation factor, RNA polymerase II, 2 -0.0328255
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0328166
CMIP c-Maf inducing protein -0.0324949
RAB1A RAB1A, member RAS oncogene family -0.0322694
PUM2 pumilio RNA-binding family member 2 -0.031715
PSD3 pleckstrin and Sec7 domain containing 3 -0.0316029
FNDC3A fibronectin type III domain containing 3A -0.0309496
MYO10 myosin X -0.0309254
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0304186
SHB Src homology 2 domain containing adaptor protein B -0.0302481
B2M beta-2-microglobulin -0.029916
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0296475
SRPK2 SRSF protein kinase 2 -0.029426
VEGFA vascular endothelial growth factor A -0.0293983
SLC38A2 solute carrier family 38, member 2 -0.0283372
HLA-B major histocompatibility complex, class I, B -0.0282915
RTN4 reticulon 4 -0.0277766
ESYT2 extended synaptotagmin-like protein 2 -0.0276958
ZNFX1 zinc finger, NFX1-type containing 1 -0.0273112
RSL1D1 ribosomal L1 domain containing 1 -0.0271139
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0268148
DENND4A DENN/MADD domain containing 4A -0.0266842
SSH2 slingshot protein phosphatase 2 -0.026042
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0259875
VMP1 vacuole membrane protein 1 -0.0259466
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0258646
TMSB10 thymosin beta 10 -0.0257655
RBM25 RNA binding motif protein 25 -0.0256824
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0253071