| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | vincristine perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the vincristine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.31058 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.151737 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.128022 |
| RPL3 | ribosomal protein L3 | 0.110978 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.100788 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0919632 |
| TPM3 | tropomyosin 3 | 0.083406 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0799477 |
| CALD1 | caldesmon 1 | 0.0748726 |
| TPM2 | tropomyosin 2 (beta) | 0.0666085 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.066414 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0614045 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0597634 |
| LDHA | lactate dehydrogenase A | 0.0589266 |
| ACTN1 | actinin, alpha 1 | 0.0585325 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0551853 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0550181 |
| KRT18 | keratin 18, type I | 0.0531711 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0515509 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0494378 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0494332 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.047935 |
| RPS4X | ribosomal protein S4, X-linked | 0.0461235 |
| MSN | moesin | 0.0455516 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0435742 |
| SPAG9 | sperm associated antigen 9 | 0.042924 |
| YBX3 | Y box binding protein 3 | 0.0412935 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0404273 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0402327 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0388563 |
| PCBP2 | poly(rC) binding protein 2 | 0.0387441 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0381773 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0380074 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0373563 |
| FLNA | filamin A, alpha | 0.0356744 |
| TPM4 | tropomyosin 4 | 0.0353774 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.035035 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0341742 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0339426 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0328204 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.0323173 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0322625 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0312541 |
| DENR | density-regulated protein | 0.0309263 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0309246 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0305869 |
| MCL1 | myeloid cell leukemia 1 | 0.0305512 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0303481 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0302596 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0300835 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0298659 |
| CALR | calreticulin | 0.0295912 |
| MKI67 | marker of proliferation Ki-67 | 0.0294363 |
| RPL4 | ribosomal protein L4 | 0.0293631 |
| UBC | ubiquitin C | 0.0290083 |
| APP | amyloid beta (A4) precursor protein | 0.0288588 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0283723 |
| SET | SET nuclear proto-oncogene | 0.0283237 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0282253 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0281844 |
| CAVIN1 | caveolae associated protein 1 | 0.0281048 |
| SVIL | supervillin | 0.0280895 |
| COPA | coatomer protein complex, subunit alpha | 0.0277616 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0276916 |
| CANX | calnexin | 0.0273549 |
| CORO1C | coronin, actin binding protein, 1C | 0.0267747 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0266869 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0265616 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0265345 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0260812 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.0257655 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0256458 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.025497 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | 0.0254681 |
| JMJD1C | jumonji domain containing 1C | 0.0253645 |
| HDGF | hepatoma-derived growth factor | 0.0253245 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0249842 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0249529 |
| MAGEA4 | melanoma antigen family A4 | 0.0248128 |
| SRP54 | signal recognition particle 54kDa | 0.0247322 |
| GOLGB1 | golgin B1 | 0.0246471 |
| ZNF638 | zinc finger protein 638 | 0.0245119 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.024439 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.02424 |
| ATP13A3 | ATPase type 13A3 | 0.0240659 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0239135 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0236034 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0233755 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0231352 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0230542 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0223995 |
| LATS2 | large tumor suppressor kinase 2 | 0.0223356 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0222863 |
| IPO7 | importin 7 | 0.021152 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0208013 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0207954 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.020778 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0206348 |
| JUN | jun proto-oncogene | 0.0206 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0204865 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.303663 |
| TMSB10 | thymosin beta 10 | -0.117805 |
| RAD51B | RAD51 paralog B | -0.114959 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.103254 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0814698 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0805042 |
| EGR1 | early growth response 1 | -0.0784657 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0721328 |
| PFN1 | profilin 1 | -0.0693347 |
| TUBA1B | tubulin, alpha 1b | -0.066327 |
| BBX | bobby sox homolog (Drosophila) | -0.0621862 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0602041 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0583689 |
| EXOC4 | exocyst complex component 4 | -0.0552429 |
| VIM | vimentin | -0.0536373 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0415645 |
| DENND5B | DENN/MADD domain containing 5B | -0.0395834 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0387698 |
| SMAD3 | SMAD family member 3 | -0.0385809 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0371072 |
| TPI1 | triosephosphate isomerase 1 | -0.0366386 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0363609 |
| RACK1 | receptor for activated C kinase 1 | -0.0362049 |
| TUBB | tubulin, beta class I | -0.0361971 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0359686 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0345135 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.034224 |
| RPL12 | ribosomal protein L12 | -0.0338923 |
| HMGA2 | high mobility group AT-hook 2 | -0.033765 |
| RPS21 | ribosomal protein S21 | -0.033563 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0335174 |
| PDE10A | phosphodiesterase 10A | -0.0329776 |
| RPL32 | ribosomal protein L32 | -0.0323225 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | -0.0315416 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.030932 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0308578 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0303351 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0303309 |
| RYR3 | ryanodine receptor 3 | -0.029694 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0295146 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0282408 |
| PHF21A | PHD finger protein 21A | -0.0281364 |
| MED13L | mediator complex subunit 13-like | -0.0277813 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0268813 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.026823 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0267231 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0264535 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0259368 |
| SMYD3 | SET and MYND domain containing 3 | -0.0257722 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0247531 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0247252 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0245481 |
| R3HDM2 | R3H domain containing 2 | -0.0243885 |
| SP3 | Sp3 transcription factor | -0.024386 |
| HMGA1 | high mobility group AT-hook 1 | -0.0243042 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0243014 |
| FBXO11 | F-box protein 11 | -0.0242271 |
| PTMA | prothymosin, alpha | -0.0240617 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0239801 |
| PCNX1 | pecanex 1 | -0.0237118 |
| SBF2 | SET binding factor 2 | -0.023659 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0234075 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0233919 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0233762 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0233154 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0230732 |
| CDK13 | cyclin-dependent kinase 13 | -0.0229796 |
| S100A11 | S100 calcium binding protein A11 | -0.0229472 |
| EFNA5 | ephrin-A5 | -0.0227923 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0226866 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0225195 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0225125 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.022098 |
| GNAS | GNAS complex locus | -0.0218747 |
| RPLP1 | ribosomal protein, large, P1 | -0.0217931 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0217847 |
| SEPTIN7 | septin 7 | -0.0216249 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0215971 |
| RPLP0 | ribosomal protein, large, P0 | -0.0215849 |
| TUBA1C | tubulin, alpha 1c | -0.0215771 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0214584 |
| RPS27 | ribosomal protein S27 | -0.021409 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0213029 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0212797 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0212587 |
| FMN1 | formin 1 | -0.0212364 |
| TMEM131 | transmembrane protein 131 | -0.0210674 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0209029 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0208559 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0208104 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0207611 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0207448 |
| TLK1 | tousled-like kinase 1 | -0.0206839 |
| EGFR | epidermal growth factor receptor | -0.0206466 |
| FTL | ferritin, light polypeptide | -0.020637 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.02028 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0201508 |
| WASF2 | WAS protein family, member 2 | -0.020103 |
| ZNF292 | zinc finger protein 292 | -0.0199643 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0199637 |
