vincristine_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description vincristine perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the vincristine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.350312
VIM vimentin 0.150203
LDHA lactate dehydrogenase A 0.109252
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0938961
POTEF POTE ankyrin domain family, member F 0.0842747
TPT1 tumor protein, translationally-controlled 1 0.0817669
RPS6 ribosomal protein S6 0.0815322
RPS4X ribosomal protein S4, X-linked 0.0796373
PRKN parkin RBR E3 ubiquitin protein ligase 0.0743055
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0717586
INHBA inhibin, beta A 0.0633137
CXCL8 chemokine (C-X-C motif) ligand 8 0.0591982
ANTXR1 anthrax toxin receptor 1 0.0563703
FMNL2 formin-like 2 0.0553167
RPS19 ribosomal protein S19 0.0552834
KRT19 keratin 19, type I 0.0517526
RPL3 ribosomal protein L3 0.0514627
RPLP1 ribosomal protein, large, P1 0.0512358
RPL19 ribosomal protein L19 0.0499604
DOCK4 dedicator of cytokinesis 4 0.0472477
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0460614
RPS12 ribosomal protein S12 0.0459118
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0444481
LSAMP limbic system-associated membrane protein 0.0443336
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0440383
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0436207
CDH13 cadherin 13 0.0431327
CREB5 cAMP responsive element binding protein 5 0.042261
TGFBR1 transforming growth factor, beta receptor 1 0.0408282
RPL37 ribosomal protein L37 0.0404728
PTPRM protein tyrosine phosphatase, receptor type, M 0.0396239
MAML3 mastermind-like 3 (Drosophila) 0.0394457
ASTN2 astrotactin 2 0.0388049
MCL1 myeloid cell leukemia 1 0.0381024
EXT1 exostosin glycosyltransferase 1 0.0377738
RPLP0 ribosomal protein, large, P0 0.0376874
FLNA filamin A, alpha 0.0364685
RPS8 ribosomal protein S8 0.0353094
RPL34 ribosomal protein L34 0.0352963
TPM4 tropomyosin 4 0.0350636
NCOR2 nuclear receptor corepressor 2 0.034774
P3H2 prolyl 3-hydroxylase 2 0.0345137
SH3KBP1 SH3-domain kinase binding protein 1 0.0345129
ACTG1 actin gamma 1 0.0331758
SMOC1 SPARC related modular calcium binding 1 0.0327407
FLNB filamin B, beta 0.0321621
RPL26 ribosomal protein L26 0.0317107
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0315394
SOX4 SRY (sex determining region Y)-box 4 0.0313748
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0311193
SQSTM1 sequestosome 1 0.0308179
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0308142
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0307411
SMAD2 SMAD family member 2 0.0302879
RPS23 ribosomal protein S23 0.0302675
RACK1 receptor for activated C kinase 1 0.0302455
RPS14 ribosomal protein S14 0.0300659
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0299036
RPS17 ribosomal protein S17 0.0296424
STC1 stanniocalcin 1 0.0296189
ESM1 endothelial cell-specific molecule 1 0.0294907
AKAP13 A kinase (PRKA) anchor protein 13 0.0290946
CD44 CD44 molecule (Indian blood group) 0.0289929
CTIF CBP80/20-dependent translation initiation factor 0.028922
RPL31 ribosomal protein L31 0.0287297
TPM3 tropomyosin 3 0.0281274
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0277062
EEF1G eukaryotic translation elongation factor 1 gamma 0.0274014
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.0268887
MSN moesin 0.0268171
NTN4 netrin 4 0.0268159
PRSS23 protease, serine, 23 0.0266167
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0265864
OXSR1 oxidative stress responsive 1 0.0265745
EZR ezrin 0.0263546
RPS3 ribosomal protein S3 0.026319
RPL7A ribosomal protein L7a 0.0262369
FTH1 ferritin, heavy polypeptide 1 0.0262244
DPYSL2 dihydropyrimidinase-like 2 0.0258853
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0255705
HLA-A major histocompatibility complex, class I, A 0.0252321
RPL9 ribosomal protein L9 0.0251419
MYO10 myosin X 0.0250378
RPL18 ribosomal protein L18 0.0249002
ZFHX3 zinc finger homeobox 3 0.0243775
PGM2L1 phosphoglucomutase 2-like 1 0.0243504
MAP7 microtubule-associated protein 7 0.0243018
CTSL cathepsin L 0.0242739
WARS1 tryptophanyl-tRNA synthetase 1 0.0242414
NRG1 neuregulin 1 0.0242082
RPS27 ribosomal protein S27 0.0241045
PSD3 pleckstrin and Sec7 domain containing 3 0.0241029
RPL36 ribosomal protein L36 0.0239846
TENM2 teneurin transmembrane protein 2 0.0239738
TMSB10 thymosin beta 10 0.0238519
NRXN3 neurexin 3 0.0238207
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0238142
XYLT1 xylosyltransferase I 0.0236885
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0234966
RPL11 ribosomal protein L11 0.0233741

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.130466
EFNA5 ephrin-A5 -0.122257
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.108223
NAMPT nicotinamide phosphoribosyltransferase -0.101402
ASPH aspartate beta-hydroxylase -0.0729124
PDE10A phosphodiesterase 10A -0.0573266
TXNRD1 thioredoxin reductase 1 -0.0519088
PCBP3 poly(rC) binding protein 3 -0.0510569
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0510496
ELL2 elongation factor, RNA polymerase II, 2 -0.0478875
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0463531
NPAS2 neuronal PAS domain protein 2 -0.0452161
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0442182
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0425943
OGA O-GlcNAcase -0.0420799
RPS27A ribosomal protein S27a -0.0390397
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0378055
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0377643
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0366621
GDA guanine deaminase -0.0344111
SMYD3 SET and MYND domain containing 3 -0.0328137
NCOA7 nuclear receptor coactivator 7 -0.0325488
COL8A1 collagen, type VIII, alpha 1 -0.032538
NEK7 NIMA-related kinase 7 -0.0305575
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0280235
RBM39 RNA binding motif protein 39 -0.0272769
SRPK2 SRSF protein kinase 2 -0.026834
FN1 fibronectin 1 -0.0267912
USP9X ubiquitin specific peptidase 9, X-linked -0.0264682
ADGRB3 adhesion G protein-coupled receptor B3 -0.0247466
CTSC cathepsin C -0.0247023
BRWD3 bromodomain and WD repeat domain containing 3 -0.0245536
COL5A2 collagen, type V, alpha 2 -0.0239829
UBC ubiquitin C -0.0238552
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0233213
RTN4 reticulon 4 -0.0232453
PM20D1 peptidase M20 domain containing 1 -0.0229207
AVL9 AVL9 homolog (S. cerevisiase) -0.0221444
NF1 neurofibromin 1 -0.022014
PBX1 pre-B-cell leukemia homeobox 1 -0.0218609
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0218271
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0215073
DPYD dihydropyrimidine dehydrogenase -0.0213899
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0212676
ZNF292 zinc finger protein 292 -0.0210781
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.020708
VCL vinculin -0.020404
KDM3A lysine (K)-specific demethylase 3A -0.0202503
MON2 MON2 homolog (S. cerevisiae) -0.0198759
AOPEP aminopeptidase O (putative) -0.0198399
BIRC6 baculoviral IAP repeat containing 6 -0.0194839
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.019467
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0194406
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0193216
TM9SF3 transmembrane 9 superfamily member 3 -0.0190275
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0187802
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0186121
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0185275
MAML2 mastermind-like 2 (Drosophila) -0.0185177
PTGR1 prostaglandin reductase 1 -0.0184935
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0184381
TBC1D19 TBC1 domain family, member 19 -0.0184368
TNPO1 transportin 1 -0.0184095
WDR26 WD repeat domain 26 -0.0181324
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0180615
PDIA4 protein disulfide isomerase family A, member 4 -0.0179477
FNDC3B fibronectin type III domain containing 3B -0.0179198
GOLGA4 golgin A4 -0.0178788
NBAS neuroblastoma amplified sequence -0.0176266
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0175901
METTL15 methyltransferase like 15 -0.0174282
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.0174142
RAB10 RAB10, member RAS oncogene family -0.0173788
KDM6A lysine (K)-specific demethylase 6A -0.0172948
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0172857
CARD16 caspase recruitment domain family, member 16 -0.0170636
PNISR PNN-interacting serine/arginine-rich protein -0.0169193
ANXA1 annexin A1 -0.0168284
ATXN2 ataxin 2 -0.0168256
MBD5 methyl-CpG binding domain protein 5 -0.0166862
PUM2 pumilio RNA-binding family member 2 -0.0166054
STRN3 striatin, calmodulin binding protein 3 -0.0165149
BCAS3 breast carcinoma amplified sequence 3 -0.0165032
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0164813
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0164379
ENAH enabled homolog (Drosophila) -0.0162987
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0161606
TGFBI transforming growth factor, beta-induced, 68kDa -0.016104
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0159637
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0159513
MARCHF6 membrane associated ring-CH-type finger 6 -0.01595
KYNU kynureninase -0.0159416
PDIA6 protein disulfide isomerase family A, member 6 -0.0157882
COG5 component of oligomeric golgi complex 5 -0.015772
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0156584
AHR aryl hydrocarbon receptor -0.0156237
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0154658
AFG2A AFG2 AAA ATPase homolog A -0.0153263
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0151215
SOD2 superoxide dismutase 2, mitochondrial -0.0149808