vincristine_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description vincristine perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the vincristine_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.135289
VIM vimentin 0.125833
DST dystonin 0.101694
SAMD4A sterile alpha motif domain containing 4A 0.092481
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0904928
EEF2 eukaryotic translation elongation factor 2 0.0861895
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0848366
COL5A2 collagen, type V, alpha 2 0.0799117
TENM3 teneurin transmembrane protein 3 0.0754312
RPS16 ribosomal protein S16 0.0717417
ENO1 enolase 1, (alpha) 0.0707961
RPS12 ribosomal protein S12 0.0634014
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0617152
RPL23 ribosomal protein L23 0.0607835
LDHA lactate dehydrogenase A 0.0599609
RPL3 ribosomal protein L3 0.0595439
ITGAV integrin, alpha V 0.0593686
TRIO trio Rho guanine nucleotide exchange factor 0.0592933
APP amyloid beta (A4) precursor protein 0.0565976
UBC ubiquitin C 0.0552206
HDAC9 histone deacetylase 9 0.0533394
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0529678
TMSB10 thymosin beta 10 0.0510854
SLIT2 slit homolog 2 (Drosophila) 0.0500628
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0498165
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0493497
RPL37 ribosomal protein L37 0.0492635
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0487228
RPS4X ribosomal protein S4, X-linked 0.0486812
ENAH enabled homolog (Drosophila) 0.0486737
ANKRD33B ankyrin repeat domain 33B 0.0479877
FOXP2 forkhead box P2 0.0479826
RPL5 ribosomal protein L5 0.0475563
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0463505
TSC22D2 TSC22 domain family, member 2 0.043609
EXT1 exostosin glycosyltransferase 1 0.0436041
RBM20 RNA binding motif protein 20 0.0432782
RPS8 ribosomal protein S8 0.0429445
NCAM2 neural cell adhesion molecule 2 0.041482
COL3A1 collagen, type III, alpha 1 0.0413034
ACTG1 actin gamma 1 0.0407633
APLP2 amyloid beta (A4) precursor-like protein 2 0.0404469
RPS19 ribosomal protein S19 0.0402106
SQSTM1 sequestosome 1 0.0393418
SRRM2 serine/arginine repetitive matrix 2 0.0389825
RAI1 retinoic acid induced 1 0.038867
PEG10 paternally expressed 10 0.0387765
CABLES1 Cdk5 and Abl enzyme substrate 1 0.0387392
FNDC3B fibronectin type III domain containing 3B 0.0380113
RPS3 ribosomal protein S3 0.0376611
SYT1 synaptotagmin I 0.0374285
EEF1G eukaryotic translation elongation factor 1 gamma 0.0369799
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0364302
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0355956
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0355878
SLC38A2 solute carrier family 38, member 2 0.0350006
RPLP1 ribosomal protein, large, P1 0.0349197
UPP1 uridine phosphorylase 1 0.034906
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0343161
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0341603
RPL11 ribosomal protein L11 0.0341086
RPS27A ribosomal protein S27a 0.0336296
SET SET nuclear proto-oncogene 0.0331995
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0331037
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0325962
PCLO piccolo presynaptic cytomatrix protein 0.0322602
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0321873
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0321795
ZSWIM6 zinc finger, SWIM-type containing 6 0.0319039
PGK1 phosphoglycerate kinase 1 0.0318215
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0317416
RPL7 ribosomal protein L7 0.0317106
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0306435
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0304386
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0302133
LYST lysosomal trafficking regulator 0.0300278
RPS17 ribosomal protein S17 0.0299891
GJA1 gap junction protein, alpha 1, 43kDa 0.0297095
PDIA3 protein disulfide isomerase family A, member 3 0.0294315
RPL30 ribosomal protein L30 0.0291845
COL11A1 collagen, type XI, alpha 1 0.0290675
HMCN1 hemicentin 1 0.0288325
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0288118
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0286198
PCDH9 protocadherin 9 0.0284711
FAT1 FAT atypical cadherin 1 0.0282654
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.028208
PCBP2 poly(rC) binding protein 2 0.0281855
RPL27 ribosomal protein L27 0.0281784
FBXO17 F-box protein 17 0.0281714
ATXN1 ataxin 1 0.0281232
SLK STE20-like kinase 0.0277821
CDH19 cadherin 19, type 2 0.0277196
LOC112694756 uncharaterized LOC112694756 0.0274913
WSB1 WD repeat and SOCS box containing 1 0.0273864
UTRN utrophin 0.0267798
HSPB1 heat shock 27kDa protein 1 0.0267537
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0267419
RPL37A ribosomal protein L37a 0.0264417
ANK2 ankyrin 2, neuronal 0.0264164

decreased expression

Symbol Name Standardized Value
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0559425
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0499205
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0445185
SOX5 SRY (sex determining region Y)-box 5 -0.0380866
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.037078
ZNF385D zinc finger protein 385D -0.0329933
KDM3A lysine (K)-specific demethylase 3A -0.0316397
NAMPT nicotinamide phosphoribosyltransferase -0.029792
SPAG9 sperm associated antigen 9 -0.0290412
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0277498
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0262973
BHLHE40 basic helix-loop-helix family, member e40 -0.0256128
FIGN fidgetin -0.0252989
RTN4 reticulon 4 -0.0252777
TUBB tubulin, beta class I -0.0238241
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0237962
BBX bobby sox homolog (Drosophila) -0.0236006
NPEPPS aminopeptidase puromycin sensitive -0.0228793
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0227949
LCORL ligand dependent nuclear receptor corepressor-like -0.022718
ACACA acetyl-CoA carboxylase alpha -0.0225878
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0225552
TUBA1B tubulin, alpha 1b -0.0220211
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0217772
EMP1 epithelial membrane protein 1 -0.0215984
SGO2 shugoshin 2 -0.0210559
TRPS1 trichorhinophalangeal syndrome I -0.0210464
SHROOM3 shroom family member 3 -0.0209216
ARHGAP15 Rho GTPase activating protein 15 -0.0207384
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.020577
H1-0 H1.0 linker histone -0.0205032
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0200636
CBX3 chromobox homolog 3 -0.0198215
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0193269
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0193012
HMGN3 high mobility group nucleosomal binding domain 3 -0.0191134
NRG1 neuregulin 1 -0.0190047
FRYL FRY-like -0.0187831
CEP170 centrosomal protein 170kDa -0.0186948
KIAA1958 KIAA1958 -0.0186301
MARCHF6 membrane associated ring-CH-type finger 6 -0.0185866
PRR11 proline rich 11 -0.0182598
BRDT bromodomain, testis-specific -0.0182502
SEC31A SEC31 homolog A (S. cerevisiae) -0.0182211
ZBTB35 zinc finger and BTB domain containing 35 -0.0176159
SCLT1 sodium channel and clathrin linker 1 -0.0173496
TCEA1 transcription elongation factor A (SII), 1 -0.0172863
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0171877
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0171834
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.017069
RNF145 ring finger protein 145 -0.0169832
EIF3H eukaryotic translation initiation factor 3, subunit H -0.016868
PNISR PNN-interacting serine/arginine-rich protein -0.0168504
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -0.0168135
FAM13A family with sequence similarity 13, member A -0.0167395
ZFPM2 zinc finger protein, FOG family member 2 -0.0167127
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0165691
PTMA prothymosin, alpha -0.0165624
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0165519
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0162155
MED13 mediator complex subunit 13 -0.0161058
ODR4 odr-4 GPCR localization factor homolog -0.0160977
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.015963
SEC63 SEC63 homolog (S. cerevisiae) -0.0158968
FAM222B family with sequence similarity 222, member B -0.0158382
CLASP2 cytoplasmic linker associated protein 2 -0.0158054
IARS1 isoleucyl-tRNA synthetase 1 -0.0158012
PRRC1 proline-rich coiled-coil 1 -0.0157295
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0155757
SALL4 spalt-like transcription factor 4 -0.0154847
FBXO11 F-box protein 11 -0.0152979
ARF4 ADP-ribosylation factor 4 -0.015292
NRXN1 neurexin 1 -0.0151688
PSPC1 paraspeckle component 1 -0.0151145
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0150098
STRN3 striatin, calmodulin binding protein 3 -0.0149602
EIF2A eukaryotic translation initiation factor 2A, 65kDa -0.014861
ATF7IP activating transcription factor 7 interacting protein -0.0147827
ABI2 abl-interactor 2 -0.0147805
USPL1 ubiquitin specific peptidase like 1 -0.0146667
AK1 adenylate kinase 1 -0.0146445
PIAS1 protein inhibitor of activated STAT, 1 -0.0144959
HELZ helicase with zinc finger -0.0144633
NFIA nuclear factor I/A -0.0144148
WDR45B WD repeat domain 45B -0.0143843
NUCB2 nucleobindin 2 -0.0142469
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0142
BABAM2 BRISC and BRCA1 A complex member 2 -0.0141999
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0141868
NXN nucleoredoxin -0.0141776
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0141607
HM13 histocompatibility (minor) 13 -0.0141475
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.014054
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A -0.0140419
DOCK7 dedicator of cytokinesis 7 -0.0140334
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0139614
RBM26 RNA binding motif protein 26 -0.0139303
FBXO34 F-box protein 34 -0.0138596
KAT6A K(lysine) acetyltransferase 6A -0.0138423
FOXC1 forkhead box C1 -0.0137637