vincristine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description vincristine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the vincristine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.174639
MYH9 myosin, heavy chain 9, non-muscle 0.112663
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.103368
ERRFI1 ERBB receptor feedback inhibitor 1 0.091693
AKAP12 A kinase (PRKA) anchor protein 12 0.0912117
LDHA lactate dehydrogenase A 0.0814117
CXCL8 chemokine (C-X-C motif) ligand 8 0.0738059
COL6A3 collagen, type VI, alpha 3 0.0636328
IGFBP3 insulin-like growth factor binding protein 3 0.0572293
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0541841
STC1 stanniocalcin 1 0.0490846
RPS6 ribosomal protein S6 0.0479431
ACTG1 actin gamma 1 0.0445905
RPS8 ribosomal protein S8 0.0406284
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0406275
CANX calnexin 0.03965
TRIO trio Rho guanine nucleotide exchange factor 0.0389896
RPS12 ribosomal protein S12 0.038624
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0384135
RPL3 ribosomal protein L3 0.038319
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0379143
RPL11 ribosomal protein L11 0.0374169
VIM vimentin 0.0368925
RPS4X ribosomal protein S4, X-linked 0.0367166
FLNA filamin A, alpha 0.0365262
PKM pyruvate kinase, muscle 0.0352792
NDRG1 N-myc downstream regulated 1 0.0351811
FTH1 ferritin, heavy polypeptide 1 0.034771
EEF2 eukaryotic translation elongation factor 2 0.0342668
RPLP1 ribosomal protein, large, P1 0.0333832
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0333024
VEGFA vascular endothelial growth factor A 0.032642
RPL13A ribosomal protein L13a 0.032347
EIF1 eukaryotic translation initiation factor 1 0.0307728
SAMD4A sterile alpha motif domain containing 4A 0.0294548
PCBP2 poly(rC) binding protein 2 0.0293391
FTL ferritin, light polypeptide 0.0293245
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0289474
IL6 interleukin 6 0.0284149
RPL19 ribosomal protein L19 0.0283791
RPS3 ribosomal protein S3 0.0280179
TPM4 tropomyosin 4 0.0275434
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0270274
NAMPT nicotinamide phosphoribosyltransferase 0.0265793
IQGAP1 IQ motif containing GTPase activating protein 1 0.0261476
RPS19 ribosomal protein S19 0.0260864
RPL37A ribosomal protein L37a 0.0252853
APLP2 amyloid beta (A4) precursor-like protein 2 0.0244418
DPYSL2 dihydropyrimidinase-like 2 0.024381
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0241973
TXNRD1 thioredoxin reductase 1 0.0237605
RPL23 ribosomal protein L23 0.0235821
FLNB filamin B, beta 0.0226579
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0224729
RPS27A ribosomal protein S27a 0.0221741
UGCG UDP-glucose ceramide glucosyltransferase 0.0219219
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0217585
APP amyloid beta (A4) precursor protein 0.0214694
RPL12 ribosomal protein L12 0.0212677
ARRDC3 arrestin domain containing 3 0.0211229
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0209447
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0208938
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0207304
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0206321
JUN jun proto-oncogene 0.0205125
DST dystonin 0.0204522
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0204303
ASPH aspartate beta-hydroxylase 0.0203088
RPL7 ribosomal protein L7 0.0201117
B2M beta-2-microglobulin 0.0200042
CD99 CD99 molecule 0.0198955
CD44 CD44 molecule (Indian blood group) 0.0198615
UBC ubiquitin C 0.019761
SMAD3 SMAD family member 3 0.0197426
MSN moesin 0.0196551
CBX3 chromobox homolog 3 0.0192137
RPS11 ribosomal protein S11 0.0189146
RPS17 ribosomal protein S17 0.0189039
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0187217
RPS20 ribosomal protein S20 0.0186569
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0186429
KTN1 kinectin 1 (kinesin receptor) 0.0185556
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.018263
RPS14 ribosomal protein S14 0.0181837
RPL5 ribosomal protein L5 0.0181551
RPL28 ribosomal protein L28 0.0177314
RPLP0 ribosomal protein, large, P0 0.0177187
MTDH metadherin 0.0176591
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0175365
RPL9 ribosomal protein L9 0.0174987
RPS13 ribosomal protein S13 0.0174354
RACK1 receptor for activated C kinase 1 0.0174262
KYNU kynureninase 0.0171853
RPS5 ribosomal protein S5 0.0169438
RPL35A ribosomal protein L35a 0.0167385
PTMA prothymosin, alpha 0.0167297
MANF mesencephalic astrocyte-derived neurotrophic factor 0.0165782
TXNIP thioredoxin interacting protein 0.0165776
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0161926
HSPA8 heat shock 70kDa protein 8 0.0161577

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0506526
PSD3 pleckstrin and Sec7 domain containing 3 -0.0464815
FN1 fibronectin 1 -0.0377965
F3 coagulation factor III (thromboplastin, tissue factor) -0.0377599
DPYD dihydropyrimidine dehydrogenase -0.0372691
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0369573
COL5A1 collagen, type V, alpha 1 -0.0344557
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0288618
KAZN kazrin, periplakin interacting protein -0.0278948
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0273207
HLA-C major histocompatibility complex, class I, C -0.0271888
HMGA2 high mobility group AT-hook 2 -0.0268138
NRXN3 neurexin 3 -0.0261141
COL6A2 collagen, type VI, alpha 2 -0.0256701
TENT5A terminal nucleotidyltransferase 5A -0.0239902
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0230669
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0227743
KMT2C lysine (K)-specific methyltransferase 2C -0.022047
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0219874
RAI14 retinoic acid induced 14 -0.0218584
BIRC6 baculoviral IAP repeat containing 6 -0.0201532
COL7A1 collagen, type VII, alpha 1 -0.0199456
ZMYND8 zinc finger, MYND-type containing 8 -0.0194912
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0191069
WSB1 WD repeat and SOCS box containing 1 -0.0190105
VDAC1 voltage-dependent anion channel 1 -0.0189235
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0187953
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0187904
MMP12 matrix metallopeptidase 12 -0.0186182
OGA O-GlcNAcase -0.0184179
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0179714
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0178197
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0178079
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0176554
HOOK2 hook microtubule-tethering protein 2 -0.0176484
RRBP1 ribosome binding protein 1 -0.017621
COL1A2 collagen, type I, alpha 2 -0.01751
TAS2R14 taste receptor, type 2, member 14 -0.0174084
SEC24D SEC24 family member D -0.0173868
QKI QKI, KH domain containing, RNA binding -0.0171852
GCC2 GRIP and coiled-coil domain containing 2 -0.0171634
SCFD1 sec1 family domain containing 1 -0.0171296
COL1A1 collagen, type I, alpha 1 -0.0170048
LOXL2 lysyl oxidase-like 2 -0.0168556
TUBA1B tubulin, alpha 1b -0.0168316
WDFY2 WD repeat and FYVE domain containing 2 -0.0165281
AK1 adenylate kinase 1 -0.0164544
FNIP1 folliculin interacting protein 1 -0.0164145
ITCH itchy E3 ubiquitin protein ligase -0.0162202
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0161184
ATG7 autophagy related 7 -0.0156424
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0152569
COG6 component of oligomeric golgi complex 6 -0.0151236
GPR173 G protein-coupled receptor 173 -0.0150636
MARCHF6 membrane associated ring-CH-type finger 6 -0.0150374
CDH13 cadherin 13 -0.0150206
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0148314
FBXO11 F-box protein 11 -0.0146945
CLIP2 CAP-GLY domain containing linker protein 2 -0.0145448
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0144174
TMEM165 transmembrane protein 165 -0.0143311
FNDC3A fibronectin type III domain containing 3A -0.0141423
TUBB tubulin, beta class I -0.0140415
PRRC1 proline-rich coiled-coil 1 -0.0139735
NBAS neuroblastoma amplified sequence -0.0139458
EGFR epidermal growth factor receptor -0.0139093
CHD9 chromodomain helicase DNA binding protein 9 -0.0138245
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0138192
SEC63 SEC63 homolog (S. cerevisiae) -0.0137846
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0137385
CDK13 cyclin-dependent kinase 13 -0.0135548
FRMD4A FERM domain containing 4A -0.0135518
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0133371
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0131898
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.013158
PDIA5 protein disulfide isomerase family A, member 5 -0.0131074
AUTS2 autism susceptibility candidate 2 -0.0130856
ARHGAP24 Rho GTPase activating protein 24 -0.0130609
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0128713
PNPLA8 patatin-like phospholipase domain containing 8 -0.0128426
MON2 MON2 homolog (S. cerevisiae) -0.012694
LAMB1 laminin, beta 1 -0.0125216
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0124767
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.012462
SEC31A SEC31 homolog A (S. cerevisiae) -0.0122264
SPDYA speedy/RINGO cell cycle regulator family member A -0.0121812
RAB1A RAB1A, member RAS oncogene family -0.0121598
CRLS1 cardiolipin synthase 1 -0.0121449
DNAH11 dynein, axonemal, heavy chain 11 -0.0120339
COPB1 coatomer protein complex, subunit beta 1 -0.0119886
CAMTA1 calmodulin binding transcription activator 1 -0.0119627
SAR1A secretion associated, Ras related GTPase 1A -0.0119172
VEGFC vascular endothelial growth factor C -0.0118921
FKBP10 FK506 binding protein 10, 65 kDa -0.0118738
SBF2 SET binding factor 2 -0.0118401
GLIS3 GLIS family zinc finger 3 -0.0118069
SEC24A SEC24 family member A -0.0117924
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0117066
ABI3BP ABI family, member 3 (NESH) binding protein -0.0116931
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0116884