vinpocetine-5859 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

192 genes differentially expressed following the vinpocetine-5859 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSM1 acyl-CoA synthetase medium-chain family member 1
AGO4 argonaute RISC catalytic component 4
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
AQP4 aquaporin 4
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
AURKC aurora kinase C
BMP1 bone morphogenetic protein 1
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BRS3 bombesin-like receptor 3
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CD6 CD6 molecule
CDHR2 cadherin-related family member 2
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEP68 centrosomal protein 68kDa
CHRM5 cholinergic receptor, muscarinic 5
CISH cytokine inducible SH2-containing protein
COPE coatomer protein complex, subunit epsilon
CTSF cathepsin F
CTSS cathepsin S
DDO D-aspartate oxidase
DLC1 DLC1 Rho GTPase activating protein
DMP1 dentin matrix acidic phosphoprotein 1
ELL2 elongation factor, RNA polymerase II, 2
ENOX1 ecto-NOX disulfide-thiol exchanger 1
FLT4 fms-related tyrosine kinase 4
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAL3ST4 galactose-3-O-sulfotransferase 4
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GLP1R glucagon-like peptide 1 receptor
GMPR guanosine monophosphate reductase
ICOSLG inducible T-cell co-stimulator ligand
IGFBP5 insulin-like growth factor binding protein 5
IPCEF1 interaction protein for cytohesin exchange factors 1
KAT2A K(lysine) acetyltransferase 2A
KLHDC8A kelch domain containing 8A
KLHL25 kelch-like family member 25
LRRN3 leucine rich repeat neuronal 3
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K7 mitogen-activated protein kinase kinase 7
MBD2 methyl-CpG binding domain protein 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MOXD1 monooxygenase, DBH-like 1
MYL10 myosin, light chain 10, regulatory
NCAPH2 non-SMC condensin II complex, subunit H2
NCKIPSD NCK interacting protein with SH3 domain
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NME5 NME/NM23 family member 5
NTF3 neurotrophin 3
OMD osteomodulin
OPTN optineurin
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PECAM1 platelet/endothelial cell adhesion molecule 1
PLA2G3 phospholipase A2, group III
PLCD1 phospholipase C, delta 1
PLD2 phospholipase D2
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLXDC1 plexin domain containing 1
PLXNB2 plexin B2
POU2F3 POU class 2 homeobox 3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRB1 proline-rich protein BstNI subfamily 1
PRICKLE3 prickle homolog 3 (Drosophila)
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTK2B protein tyrosine kinase 2 beta
PTPRH protein tyrosine phosphatase, receptor type, H
QKI QKI, KH domain containing, RNA binding
RPL7 ribosomal protein L7
RUNDC3B RUN domain containing 3B
RUNX1 runt-related transcription factor 1
RWDD2A RWD domain containing 2A
SAA4 serum amyloid A4, constitutive
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SHOX2 short stature homeobox 2
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SMG7 SMG7 nonsense mediated mRNA decay factor
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STAB2 stabilin 2
TBL2 transducin (beta)-like 2
TBX6 T-box 6
TGM2 transglutaminase 2
TLE4 transducin-like enhancer of split 4
TMEM180 transmembrane protein 180
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNP2 transition protein 2 (during histone to protamine replacement)
TRD T cell receptor delta locus
UBOX5 U-box domain containing 5
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR62 WD repeat domain 62
WDTC1 WD and tetratricopeptide repeats 1
WNT7A wingless-type MMTV integration site family, member 7A
ZFP30 ZFP30 zinc finger protein
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACKR3 atypical chemokine receptor 3
ACSF2 acyl-CoA synthetase family member 2
ALPK1 alpha-kinase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARSJ arylsulfatase family, member J
ATP7B ATPase, Cu++ transporting, beta polypeptide
BAHD1 bromo adjacent homology domain containing 1
BAK1 BCL2-antagonist/killer 1
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C11ORF73 chromosome 11 open reading frame 73
C17ORF70 chromosome 17 open reading frame 70
C4ORF19 chromosome 4 open reading frame 19
C6ORF47 chromosome 6 open reading frame 47
CASZ1 castor zinc finger 1
CCDC68 coiled-coil domain containing 68
CCS copper chaperone for superoxide dismutase
CEP70 centrosomal protein 70kDa
CIR1 corepressor interacting with RBPJ, 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL2 chemokine (C-X-C motif) ligand 2
DCAF13 DDB1 and CUL4 associated factor 13
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DPH2 DPH2 homolog (S. cerevisiae)
DTX4 deltex 4, E3 ubiquitin ligase
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EML4 echinoderm microtubule associated protein like 4
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EVPL envoplakin
FAIM Fas apoptotic inhibitory molecule
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GNL1 guanine nucleotide binding protein-like 1
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GSTT1 glutathione S-transferase theta 1
HINFP histone H4 transcription factor
HIST1H2BE histone cluster 1, H2be
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
ICK intestinal cell (MAK-like) kinase
INF2 inverted formin, FH2 and WH2 domain containing
IPP intracisternal A particle-promoted polypeptide
IREB2 iron-responsive element binding protein 2
IRF1 interferon regulatory factor 1
JUNB jun B proto-oncogene
LRRC42 leucine rich repeat containing 42
LYPD3 LY6/PLAUR domain containing 3
LYRM2 LYR motif containing 2
MECR mitochondrial trans-2-enoyl-CoA reductase
METRN meteorin, glial cell differentiation regulator
MFSD12 major facilitator superfamily domain containing 12
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
NINJ1 ninjurin 1
NPM3 nucleophosmin/nucleoplasmin 3
NRGN neurogranin (protein kinase C substrate, RC3)
NT5DC3 5'-nucleotidase domain containing 3
OTUD3 OTU deubiquitinase 3
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHACTR4 phosphatase and actin regulator 4
PILRB paired immunoglobin-like type 2 receptor beta
PLEKHO2 pleckstrin homology domain containing, family O member 2
PPP1R26 protein phosphatase 1, regulatory subunit 26
RAB33B RAB33B, member RAS oncogene family
RABGGTA Rab geranylgeranyltransferase, alpha subunit
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RHOBTB1 Rho-related BTB domain containing 1
RNF121 ring finger protein 121
RPL10L ribosomal protein L10-like
SCAMP5 secretory carrier membrane protein 5
SCN1B sodium channel, voltage gated, type I beta subunit
SH3BGR SH3 domain binding glutamate-rich protein
SLC22A18 solute carrier family 22, member 18
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOBP sine oculis binding protein homolog (Drosophila)
SREK1IP1 SREK1-interacting protein 1
STX5 syntaxin 5
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAGLN3 transgelin 3
TAOK1 TAO kinase 1
TEAD3 TEA domain family member 3
TESK1 testis-specific kinase 1
TMCC2 transmembrane and coiled-coil domain family 2
TMEM62 transmembrane protein 62
TRAPPC6A trafficking protein particle complex 6A
TRIM45 tripartite motif containing 45
TSKU tsukushi, small leucine rich proteoglycan
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
ZBTB39 zinc finger and BTB domain containing 39
ZC4H2 zinc finger, C4H2 domain containing
ZFHX3 zinc finger homeobox 3
ZNF282 zinc finger protein 282
ZNF329 zinc finger protein 329
ZNF862 zinc finger protein 862