vitiligo Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached. (Experimental Factor Ontology, EFO_0004208)
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Genes

215 genes co-occuring with the disease vitiligo in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TYR tyrosinase 2.26059
PMEL premelanosome protein 1.79751
NLRP1 NLR family, pyrin domain containing 1 1.7496
TYRP1 tyrosinase-related protein 1 1.68181
DCT dopachrome tautomerase 1.67096
C12ORF10 chromosome 12 open reading frame 10 1.52732
FBXO11 F-box protein 11 1.49921
MITF microphthalmia-associated transcription factor 1.44386
CAT catalase 1.4149
AIRE autoimmune regulator 1.41052
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 1.39214
MCHR1 melanin-concentrating hormone receptor 1 1.3385
MLANA melan-A 1.32192
STX17 syntaxin 17 1.2717
SMOC2 SPARC related modular calcium binding 2 1.26081
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 1.24906
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 1.20829
CD4 CD4 molecule 1.1841
FOXD3 forkhead box D3 1.05555
HLA-A major histocompatibility complex, class I, A 1.00879
STRN3 striatin, calmodulin binding protein 3 1.00457
HIST3H3 histone cluster 3, H3 0.986428
TPO thyroid peroxidase 0.985585
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.954943
DDR1 discoidin domain receptor tyrosine kinase 1 0.906909
TBP TATA box binding protein 0.899924
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 0.893359
MDM1 Mdm1 nuclear protein homolog (mouse) 0.889258
PRDX5 peroxiredoxin 5 0.889258
ASIP agouti signaling protein 0.868368
GPX1 glutathione peroxidase 1 0.838066
SOD2 superoxide dismutase 2, mitochondrial 0.837656
BCO2 beta-carotene oxygenase 2 0.834788
GPX5 glutathione peroxidase 5 0.829869
GPX4 glutathione peroxidase 4 0.826589
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 0.812232
HLA-C major histocompatibility complex, class I, C 0.787213
PAH phenylalanine hydroxylase 0.78066
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.779841
XIRP1 xin actin binding repeat containing 1 0.774114
TG thyroglobulin 0.75412
RPL13 ribosomal protein L13 0.750457
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.75005
C6ORF10 chromosome 6 open reading frame 10 0.74883
PTPRD protein tyrosine phosphatase, receptor type, D 0.743141
RNASET2 ribonuclease T2 0.740705
IL2 interleukin 2 0.732191
XBP1 X-box binding protein 1 0.731786
SYNC syncoilin, intermediate filament protein 0.724907
NPS neuropeptide S 0.709572
FGF2 fibroblast growth factor 2 (basic) 0.698313
RAB38 RAB38, member RAS oncogene family 0.67113
TOB2 transducer of ERBB2, 2 0.670732
CDK5RAP1 CDK5 regulatory subunit associated protein 1 0.660008
GCH1 GTP cyclohydrolase 1 0.652089
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 0.641039
POMC proopiomelanocortin 0.637102
TDO2 tryptophan 2,3-dioxygenase 0.634742
RPL39L ribosomal protein L39-like 0.624927
FOXP3 forkhead box P3 0.616703
VIT vitrin 0.616312
KITLG KIT ligand 0.610448
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.605762
IL20RA interleukin 20 receptor, alpha 0.596012
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 0.594064
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.587444
FGFR1OP FGFR1 oncogene partner 0.585108
EDN1 endothelin 1 0.577327
ICAM1 intercellular adhesion molecule 1 0.577327
GCHFR GTP cyclohydrolase I feedback regulator 0.575772
KRT39 keratin 39, type I 0.561004
IKZF4 IKAROS family zinc finger 4 (Eos) 0.560227
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 0.558285
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.55712
GIF gastric intrinsic factor (vitamin B synthesis) 0.555956
C1QTNF6 C1q and tumor necrosis factor related protein 6 0.554403
CD79A CD79a molecule, immunoglobulin-associated alpha 0.545868
LGI3 leucine-rich repeat LGI family, member 3 0.524974
OCA2 oculocutaneous albinism II 0.521888
MSRB1 methionine sulfoxide reductase B1 0.518805
EIF4A1 eukaryotic translation initiation factor 4A1 0.51842
IL2RA interleukin 2 receptor, alpha 0.512264
COMT catechol-O-methyltransferase 0.506507
CLTA clathrin, light chain A 0.506507
PYDC1 PYD (pyrin domain) containing 1 0.504207
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.485125
IL22RA2 interleukin 22 receptor, alpha 2 0.480945
NPY neuropeptide Y 0.469576
CREB1 cAMP responsive element binding protein 1 0.468819
MUC15 mucin 15, cell surface associated 0.468819
MAGEA3 melanoma antigen family A3 0.468063
IFNA13 interferon, alpha 13 0.465416
UBASH3A ubiquitin associated and SH3 domain containing A 0.463149
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.457864
NOV nephroblastoma overexpressed 0.457487
COL12A1 collagen, type XII, alpha 1 0.4443
HSPA4 heat shock 70kDa protein 4 0.431519
SEPT4 septin 4 0.431519
ZNHIT2 zinc finger, HIT-type containing 2 0.427015
EHF ets homologous factor 0.425514
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.424389
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.418768
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.413153
TH tyrosine hydroxylase 0.397471
MAOA monoamine oxidase A 0.395608
PRF1 perforin 1 (pore forming protein) 0.390025
MAN1A1 mannosidase, alpha, class 1A, member 1 0.382223
GSTM1 glutathione S-transferase mu 1 0.381852
PAX3 paired box 3 0.381852
CXCR3 chemokine (C-X-C motif) receptor 3 0.380368
CALR calreticulin 0.378143
IFNLR1 interferon, lambda receptor 1 0.37629
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.37592
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.37555
QDPR quinoid dihydropteridine reductase 0.36741
GAST gastrin 0.363347
SH2B3 SH2B adaptor protein 3 0.360026
TXN thioredoxin 0.358183
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.357814
TNF tumor necrosis factor 0.350084
SIAE sialic acid acetylesterase 0.349717
RHO rhodopsin 0.344207
ZMIZ1 zinc finger, MIZ-type containing 1 0.342739
NCAM1 neural cell adhesion molecule 1 0.342372
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.337242
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.335046
CD160 CD160 molecule 0.335046
FN1 fibronectin 1 0.334315
IFNE interferon, epsilon 0.332487
PAAF1 proteasomal ATPase-associated factor 1 0.331391
HLA-B major histocompatibility complex, class I, B 0.32774
GSTA3 glutathione S-transferase alpha 3 0.325552
GSTA2 glutathione S-transferase alpha 2 0.324094
GSTA4 glutathione S-transferase alpha 4 0.323002
CCR6 chemokine (C-C motif) receptor 6 0.320817
TAC1 tachykinin, precursor 1 0.317909
ACP5 acid phosphatase 5, tartrate resistant 0.317909
GSTA1 glutathione S-transferase alpha 1 0.317545
UVRAG UV radiation resistance associated 0.316456
TPH1 tryptophan hydroxylase 1 0.316092
C4A complement component 4A (Rodgers blood group) 0.311014
HLA-G major histocompatibility complex, class I, G 0.308118
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.304864
TP53 tumor protein p53 0.302337
NFIA nuclear factor I/A 0.301976
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.295851
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 0.294053
NFIB nuclear factor I/B 0.289386
TSLP thymic stromal lymphopoietin 0.287593
IFNL2 interferon, lambda 2 0.285444
AHR aryl hydrocarbon receptor 0.279367
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.273308
BATF2 basic leucine zipper transcription factor, ATF-like 2 0.272597
AQP3 aquaporin 3 (Gill blood group) 0.271174
CLEC11A C-type lectin domain family 11, member A 0.267267
IL17A interleukin 17A 0.265494
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 0.264431
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.263368
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.260184
EDNRB endothelin receptor type B 0.25983
CLEC2A C-type lectin domain family 2, member A 0.257005
NFE2L2 nuclear factor, erythroid 2-like 2 0.256299
CD80 CD80 molecule 0.254888
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.253479
GSTTP1 glutathione S-transferase theta pseudogene 1 0.250311
GSTT1 glutathione S-transferase theta 1 0.250311
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 0.249608
IL10RB interleukin 10 receptor, beta 0.248554
RANBP2 RAN binding protein 2 0.247501
HCG4P11 HLA complex group 4 pseudogene 11 0.240148
HLA-F major histocompatibility complex, class I, F 0.240148
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 0.235964
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.231448
PTBP2 polypyrimidine tract binding protein 2 0.231102
ASMT acetylserotonin O-methyltransferase 0.228333
MELK maternal embryonic leucine zipper kinase 0.218034
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.215314
INS insulin 0.214297
HNF1A HNF1 homeobox A 0.210253
LAD1 ladinin 1 0.207578
CD207 CD207 molecule, langerin 0.20658
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.203275
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.202946
BTNL2 butyrophilin-like 2 0.201308
IFNA1 interferon, alpha 1 0.200982
LPO lactoperoxidase 0.200006
EDN3 endothelin 3 0.197742
SOX10 SRY (sex determining region Y)-box 10 0.193915
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.192344
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.190476
FLNA filamin A, alpha 0.189551
MINK1 misshapen-like kinase 1 0.187415
PKD2L1 polycystic kidney disease 2-like 1 0.18621
RERE arginine-glutamic acid dipeptide (RE) repeats 0.18621
IL22RA1 interleukin 22 receptor, alpha 1 0.180367
CD59 CD59 molecule, complement regulatory protein 0.17896
CARD8 caspase recruitment domain family, member 8 0.174617
NLRC4 NLR family, CARD domain containing 4 0.173571
DNAH5 dynein, axonemal, heavy chain 5 0.173571
IL4 interleukin 4 0.170054
FOXN1 forkhead box N1 0.169571
CALCA calcitonin-related polypeptide alpha 0.168148
RPGRIP1L RPGRIP1-like 0.168148
RD3 retinal degeneration 3 0.166995
G6PD glucose-6-phosphate dehydrogenase 0.166095
PRPH2 peripherin 2 (retinal degeneration, slow) 0.165655
HECA headcase homolog (Drosophila) 0.164786
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 0.164571
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.164571
RBP3 retinol binding protein 3, interstitial 0.163729
DRD5 dopamine receptor D5 0.162109
BTLA B and T lymphocyte associated 0.160203
RAET1E retinoic acid early transcript 1E 0.159838
TNC tenascin C 0.158951
MFRP membrane frizzled-related protein 0.158778