weakness Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description state of being infirm or less strong than normal (Mammalian Phenotype Ontology, MP_0000746)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000746
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Genes

96 gene mutations causing the weakness phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACHE acetylcholinesterase (Yt blood group)
AGRN agrin
AGTPBP1 ATP/GTP binding protein 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALPL alkaline phosphatase, liver/bone/kidney
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGAP10 Rho GTPase activating protein 10
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARX aristaless related homeobox
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BTD biotinidase
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CCR10 chemokine (C-C motif) receptor 10
CDK5 cyclin-dependent kinase 5
CDON cell adhesion associated, oncogene regulated
CHKB choline kinase beta
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CHSY1 chondroitin sulfate synthase 1
CISD2 CDGSH iron sulfur domain 2
CLCN1 chloride channel, voltage-sensitive 1
CNTN1 contactin 1
CNTNAP1 contactin associated protein 1
COL4A1 collagen, type IV, alpha 1
CTSF cathepsin F
CYCS cytochrome c, somatic
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHCR7 7-dehydrocholesterol reductase
DOCK3 dedicator of cytokinesis 3
DST dystonin
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR2 early growth response 2
FGF14 fibroblast growth factor 14
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GAL3ST1 galactose-3-O-sulfotransferase 1
GALC galactosylceramidase
GAN gigaxonin
GNAS GNAS complex locus
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRM1 glutamate receptor, metabotropic 1
HOXC13 homeobox C13
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
ILF3 interleukin enhancer binding factor 3, 90kDa
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10
KEL Kell blood group, metallo-endopeptidase
KIF14 kinesin family member 14
KIFAP3 kinesin-associated protein 3
LAMC1 laminin, gamma 1 (formerly LAMB2)
LHX6 LIM homeobox 6
LTN1 listerin E3 ubiquitin protein ligase 1
LYST lysosomal trafficking regulator
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MCOLN1 mucolipin 1
MET MET proto-oncogene, receptor tyrosine kinase
MIR205 microRNA 205
MPZ myelin protein zero
NDRG1 N-myc downstream regulated 1
NOVA1 neuro-oncological ventral antigen 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PLP1 proteolipid protein 1
PSAP prosaposin
PURA purine-rich element binding protein A
QKI QKI, KH domain containing, RNA binding
SALL3 spalt-like transcription factor 3
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SMAP1 small ArfGAP 1
SMN1 survival of motor neuron 1, telomeric
SNRPN small nuclear ribonucleoprotein polypeptide N
SOD2 superoxide dismutase 2, mitochondrial
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPTBN4 spectrin, beta, non-erythrocytic 4
SYNE1 spectrin repeat containing, nuclear envelope 1
SYNGAP1 synaptic Ras GTPase activating protein 1
SYNJ1 synaptojanin 1
TH tyrosine hydroxylase
TK2 thymidine kinase 2, mitochondrial
TNS1 tensin 1
TP63 tumor protein p63
TPH2 tryptophan hydroxylase 2
TPP1 tripeptidyl peptidase I
TRAK1 trafficking protein, kinesin binding 1
TRIM32 tripartite motif containing 32
UNC13A unc-13 homolog A (C. elegans)
UNC79 unc-79 homolog (C. elegans)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
WASF1 WAS protein family, member 1
ZMPSTE24 zinc metallopeptidase STE24