worse Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

408 genes co-occuring with the biological term worse in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABI1 abl-interactor 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACE angiotensin I converting enzyme
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACTN3 actinin, alpha 3 (gene/pseudogene)
ACTN4 actinin, alpha 4
ACVRL1 activin A receptor type II-like 1
ADA adenosine deaminase
AFP alpha-fetoprotein
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP3 A kinase (PRKA) anchor protein 3
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALPL alkaline phosphatase, liver/bone/kidney
AMACR alpha-methylacyl-CoA racemase
AMPD1 adenosine monophosphate deaminase 1
API5 apoptosis inhibitor 5
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARTN artemin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ASXL1 additional sex combs like transcriptional regulator 1
ATAD2 ATPase family, AAA domain containing 2
ATOH1 atonal homolog 1 (Drosophila)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAALC brain and acute leukemia, cytoplasmic
BAG1 BCL2-associated athanogene
BAG3 BCL2-associated athanogene 3
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BDNF brain-derived neurotrophic factor
BGN biglycan
BIRC5 baculoviral IAP repeat containing 5
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
C11ORF30 chromosome 11 open reading frame 30
C4B complement component 4B (Chido blood group)
CA9 carbonic anhydrase IX
CAPRIN1 cell cycle associated protein 1
CARD8 caspase recruitment domain family, member 8
CARTPT CART prepropeptide
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCND1 cyclin D1
CCNE1 cyclin E1
CCNG2 cyclin G2
CCR10 chemokine (C-C motif) receptor 10
CCR7 chemokine (C-C motif) receptor 7
CD151 CD151 molecule (Raph blood group)
CD163 CD163 molecule
CD226 CD226 molecule
CD24 CD24 molecule
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD82 CD82 molecule
CD8A CD8a molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFH complement factor H
CFLAR CASP8 and FADD-like apoptosis regulator
CFP complement factor properdin
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGA glycoprotein hormones, alpha polypeptide
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHEK2 checkpoint kinase 2
COMT catechol-O-methyltransferase
CPB2 carboxypeptidase B2 (plasma)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRLF2 cytokine receptor-like factor 2
CRP C-reactive protein, pentraxin-related
CSF1R colony stimulating factor 1 receptor
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTAG1B cancer/testis antigen 1B
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
CUL1 cullin 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYR61 cysteine-rich, angiogenic inducer, 61
DAO D-amino-acid oxidase
DCDC2 doublecortin domain containing 2
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1
DICER1 dicer 1, ribonuclease type III
DIO2 deiodinase, iodothyronine, type II
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPP4 dipeptidyl-peptidase 4
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DSG1 desmoglein 1
DTNBP1 dystrobrevin binding protein 1
DUSP4 dual specificity phosphatase 4
E2F4 E2F transcription factor 4, p107/p130-binding
E2F5 E2F transcription factor 5, p130-binding
EDN1 endothelin 1
EFNA1 ephrin-A1
EFNA2 ephrin-A2
EGFR epidermal growth factor receptor
EGLN2 egl-9 family hypoxia-inducible factor 2
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELAVL1 ELAV like RNA binding protein 1
ENG endoglin
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 epoxide hydrolase 2, cytoplasmic
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERCC1 excision repair cross-complementation group 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EVI5 ecotropic viral integration site 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
F11 coagulation factor XI
FAAH fatty acid amide hydrolase
FAP fibroblast activation protein, alpha
FAS Fas cell surface death receptor
FGB fibrinogen beta chain
FGF7 fibroblast growth factor 7
FGFR2 fibroblast growth factor receptor 2
FHIT fragile histidine triad
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FMR1 fragile X mental retardation 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOLR1 folate receptor 1 (adult)
FOXC2 forkhead box C2
FOXP1 forkhead box P1
FOXP3 forkhead box P3
FSCN1 fascin actin-bundling protein 1
FSCN2 fascin actin-bundling protein 2, retinal
G6PC2 glucose-6-phosphatase, catalytic, 2
GATA2 GATA binding protein 2
GFAP glial fibrillary acidic protein
GNAS GNAS complex locus
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAMP hepcidin antimicrobial peptide
HDAC1 histone deacetylase 1
HDGF hepatoma-derived growth factor
HFE hemochromatosis
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-B major histocompatibility complex, class I, B
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-G major histocompatibility complex, class I, G
HLTF helicase-like transcription factor
HNF4A hepatocyte nuclear factor 4, alpha
HOXB7 homeobox B7
HP haptoglobin
HRAS Harvey rat sarcoma viral oncogene homolog
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA4 heat shock 70kDa protein 4
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFN1@ interferon, type 1, cluster
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL10 interleukin 10
IL13 interleukin 13
IL17F interleukin 17F
IL18 interleukin 18
IL1B interleukin 1, beta
IL2RA interleukin 2 receptor, alpha
IL6 interleukin 6
IL6R interleukin 6 receptor
IRF4 interferon regulatory factor 4
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA9 integrin, alpha 9
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAG1 jagged 1
KAT2B K(lysine) acetyltransferase 2B
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KDR kinase insert domain receptor
KEAP1 kelch-like ECH-associated protein 1
KIFC1 kinesin family member C1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT75 keratin 75, type II
LPA lipoprotein, Lp(a)
LZTS1 leucine zipper, putative tumor suppressor 1
MACC1 metastasis associated in colon cancer 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPT microtubule-associated protein tau
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECOM MDS1 and EVI1 complex locus
MEG3 maternally expressed 3 (non-protein coding)
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MICA MHC class I polypeptide-related sequence A
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR101-1 microRNA 101-1
MIR1246 microRNA 1246
MIR125A microRNA 125a
MIR137 microRNA 137
MIR17 microRNA 17
MIR200B microRNA 200b
MIR205 microRNA 205
MIR20A microRNA 20a
MIR214 microRNA 214
MIR215 microRNA 215
MIR224 microRNA 224
MIR27A microRNA 27a
MIR34A microRNA 34a
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
MPO myeloperoxidase
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH7 myosin, heavy chain 7, cardiac muscle, beta
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCOA2 nuclear receptor coactivator 2
NCOA3 nuclear receptor coactivator 3
NEFH neurofilament, heavy polypeptide
NFE2L2 nuclear factor, erythroid 2-like 2
NFIB nuclear factor I/B
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGFR nerve growth factor receptor
NKX2-1 NK2 homeobox 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NOV nephroblastoma overexpressed
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPPB natriuretic peptide B
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
NUCLEOLIN nucleolin multifunctional protein
OPRM1 opioid receptor, mu 1
PARD3 par-3 family cell polarity regulator
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PAX6 paired box 6
PCDH10 protocadherin 10
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELP1 proline, glutamate and leucine rich protein 1
PFN2 profilin 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAU plasminogen activator, urokinase
PLCG1 phospholipase C, gamma 1
PLK1 polo-like kinase 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PON1 paraoxonase 1
POSTN periostin, osteoblast specific factor
POU5F1 POU class 5 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PRKCI protein kinase C, iota
PROCR protein C receptor, endothelial
PROM1 prominin 1
PRPH2 peripherin 2 (retinal degeneration, slow)
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PVRL4 poliovirus receptor-related 4
RABL6 RAB, member RAS oncogene family-like 6
RARB retinoic acid receptor, beta
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RHOH ras homolog family member H
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPS19 ribosomal protein S19
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RSF1 remodeling and spacing factor 1
RUNX3 runt-related transcription factor 3
S100B S100 calcium binding protein B
S100P S100 calcium binding protein P
S1PR1 sphingosine-1-phosphate receptor 1
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SETD2 SET domain containing 2
SFTPA1 surfactant protein A1
SFTPD surfactant protein D
SH3PXD2A SH3 and PX domains 2A
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SIPA1 signal-induced proliferation-associated 1
SIRT1 sirtuin 1
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SNAI2 snail family zinc finger 2
SNRPN small nuclear ribonucleoprotein polypeptide N
SPOP speckle-type POZ protein
SPP1 secreted phosphoprotein 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUMO4 small ubiquitin-like modifier 4
TBX4 T-box 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERT telomerase reverse transcriptase
TET2 tet methylcytosine dioxygenase 2
TF transferrin
TFAM transcription factor A, mitochondrial
TG thyroglobulin
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TNNI3 troponin I type 3 (cardiac)
TNNT2 troponin T type 2 (cardiac)
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TPO thyroid peroxidase
TRA2B transformer 2 beta homolog (Drosophila)
TRIM24 tripartite motif containing 24
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TTR transthyretin
TWIST1 twist family bHLH transcription factor 1
UBE3A ubiquitin protein ligase E3A
UCN urocortin
UCN2 urocortin 2
ULK1 unc-51 like autophagy activating kinase 1
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
WT1 Wilms tumor 1
XBP1 X-box binding protein 1
XDH xanthine dehydrogenase
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZNF148 zinc finger protein 148
ZNF582 zinc finger protein 582
ZNF703 zinc finger protein 703