wortmannin-2703 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the wortmannin-2703 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM20 ADAM metallopeptidase domain 20
ADGRB1 adhesion G protein-coupled receptor B1
AIM2 absent in melanoma 2
AMACR alpha-methylacyl-CoA racemase
APOE apolipoprotein E
AXL AXL receptor tyrosine kinase
BHMT2 betaine--homocysteine S-methyltransferase 2
BLZF1 basic leucine zipper nuclear factor 1
BTF3P11 basic transcription factor 3 pseudogene 11
C17ORF53 chromosome 17 open reading frame 53
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CCDC102B coiled-coil domain containing 102B
CCL4 chemokine (C-C motif) ligand 4
CD84 CD84 molecule
CEP295 centrosomal protein 295kDa
CIB2 calcium and integrin binding family member 2
CLDN1 claudin 1
DDR1 discoidin domain receptor tyrosine kinase 1
DPP4 dipeptidyl-peptidase 4
EFNB2 ephrin-B2
EGR4 early growth response 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
EVI5 ecotropic viral integration site 5
FLOT1 flotillin 1
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GABARAPL1 GABA(A) receptor-associated protein like 1
GLRA2 glycine receptor, alpha 2
GPR37L1 G protein-coupled receptor 37 like 1
GPR45 G protein-coupled receptor 45
HCRTR2 hypocretin (orexin) receptor 2
HEG1 heart development protein with EGF-like domains 1
HOXB1 homeobox B1
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGL immunoglobulin lambda locus
IL24 interleukin 24
IL3RA interleukin 3 receptor, alpha (low affinity)
IRS4 insulin receptor substrate 4
KCTD20 potassium channel tetramerization domain containing 20
KIAA1107 KIAA1107
KIF24 kinesin family member 24
KLK7 kallikrein-related peptidase 7
KMT2A lysine (K)-specific methyltransferase 2A
KYNU kynureninase
LPP LIM domain containing preferred translocation partner in lipoma
MAN1A1 mannosidase, alpha, class 1A, member 1
MARC2 mitochondrial amidoxime reducing component 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEP1B meprin A, beta
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC6 mucin 6, oligomeric mucus/gel-forming
MYL10 myosin, light chain 10, regulatory
NCOR2 nuclear receptor corepressor 2
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NMBR neuromedin B receptor
NME8 NME/NM23 family member 8
NMUR1 neuromedin U receptor 1
NOP16 NOP16 nucleolar protein
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OCM2 oncomodulin 2
OR10H1 olfactory receptor, family 10, subfamily H, member 1
PACRG PARK2 co-regulated
PAX8 paired box 8
PDX1 pancreatic and duodenal homeobox 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLCE1 phospholipase C, epsilon 1
PQLC2 PQ loop repeat containing 2
PRO2964 uncharacterized protein PRO2964
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASAL2 RAS protein activator like 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RPL23AP32 ribosomal protein L23a pseudogene 32
SEC14L4 SEC14-like 4 (S. cerevisiae)
SEMG2 semenogelin II
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SH3D21 SH3 domain containing 21
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SNAP25 synaptosomal-associated protein, 25kDa
SQSTM1 sequestosome 1
SUGCT succinyl-CoA:glutarate-CoA transferase
SULF1 sulfatase 1
TAPT1 transmembrane anterior posterior transformation 1
TECTA tectorin alpha
TLX3 T-cell leukemia homeobox 3
TM4SF1 transmembrane 4 L six family member 1
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TP53I11 tumor protein p53 inducible protein 11
TRPS1 trichorhinophalangeal syndrome I
TTN titin
TUBB2A tubulin, beta 2A class IIa
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VCX2 variable charge, X-linked 2
VSX1 visual system homeobox 1
XCL1 chemokine (C motif) ligand 1

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADGRE3 adhesion G protein-coupled receptor E3
AGO3 argonaute RISC catalytic component 3
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOL6 apolipoprotein L, 6
ARRB1 arrestin, beta 1
AZU1 azurocidin 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BTF3P12 basic transcription factor 3 pseudogene 12
CBR1 carbonyl reductase 1
CCL2 chemokine (C-C motif) ligand 2
CDK3 cyclin-dependent kinase 3
CEP97 centrosomal protein 97kDa
CFP complement factor properdin
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN2 chloride channel, voltage-sensitive 2
CNN1 calponin 1, basic, smooth muscle
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNR2 cannabinoid receptor 2 (macrophage)
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DNM3 dynamin 3
DOC2A double C2-like domains, alpha
FAM118A family with sequence similarity 118, member A
FAM184A family with sequence similarity 184, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FKBP14 FK506 binding protein 14, 22 kDa
FMOD fibromodulin
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRMPD1 FERM and PDZ domain containing 1
GATA4 GATA binding protein 4
GATA6 GATA binding protein 6
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H2AJ histone cluster 1, H2aj
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXC8 homeobox C8
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IDI2-AS1 IDI2 antisense RNA 1
ITGA10 integrin, alpha 10
KIAA0753 KIAA0753
KLHL28 kelch-like family member 28
KRT81 keratin 81, type II
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LOXL3 lysyl oxidase-like 3
MAPK13 mitogen-activated protein kinase 13
MARC1 mitochondrial amidoxime reducing component 1
MMP9 matrix metallopeptidase 9
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NNAT neuronatin
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PARP16 poly (ADP-ribose) polymerase family, member 16
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDLIM2 PDZ and LIM domain 2 (mystique)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIR pirin (iron-binding nuclear protein)
PLA2G12A phospholipase A2, group XIIA
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PRDM12 PR domain containing 12
PROCR protein C receptor, endothelial
PRR7 proline rich 7 (synaptic)
PSAT1 phosphoserine aminotransferase 1
RBM47 RNA binding motif protein 47
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SENP7 SUMO1/sentrin specific peptidase 7
SERINC5 serine incorporator 5
SGPP1 sphingosine-1-phosphate phosphatase 1
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH2D4A SH2 domain containing 4A
SLC12A9 solute carrier family 12, member 9
SLC16A4 solute carrier family 16, member 4
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SOX12 SRY (sex determining region Y)-box 12
SPATA2L spermatogenesis associated 2-like
SYNPO2L synaptopodin 2-like
TAGLN transgelin
TBC1D17 TBC1 domain family, member 17
TESC tescalcin
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TMEM53 transmembrane protein 53
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRAF2 TNF receptor-associated factor 2
TRIB3 tribbles pseudokinase 3
TSPYL2 TSPY-like 2
UPB1 ureidopropionase, beta
VLDLR very low density lipoprotein receptor
XYLT2 xylosyltransferase II
YIPF1 Yip1 domain family, member 1
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF749 zinc finger protein 749
ZNF76 zinc finger protein 76