wrn Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Werner syndrome, RecQ helicase-like|This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7486)
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Genes

45 genes co-occuring with the biological term wrn in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BLM Bloom syndrome, RecQ helicase-like
CCNT1 cyclin T1
CHEK1 checkpoint kinase 1
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DNA2 DNA replication helicase/nuclease 2
ERCC5 excision repair cross-complementation group 5
EXO1 exonuclease 1
FEN1 flap structure-specific endonuclease 1
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HSF4 heat shock transcription factor 4
KAT2B K(lysine) acetyltransferase 2B
LIG3 ligase III, DNA, ATP-dependent
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MUS81 MUS81 structure-specific endonuclease subunit
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NEIL1 nei endonuclease VIII-like 1 (E. coli)
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PML promyelocytic leukemia
POLN polymerase (DNA directed) nu
POT1 protection of telomeres 1
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PURG purine-rich element binding protein G
RAD18 RAD18 E3 ubiquitin protein ligase
RAD51 RAD51 recombinase
RAD52 RAD52 homolog (S. cerevisiae)
RECQL RecQ helicase-like
RECQL4 RecQ protein-like 4
REV1 REV1, polymerase (DNA directed)
RPA1 replication protein A1, 70kDa
SIRT1 sirtuin 1
SIRT6 sirtuin 6
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TERF2 telomeric repeat binding factor 2
TP53 tumor protein p53
WRN Werner syndrome, RecQ helicase-like
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6