wt1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Wilms tumor 1|This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015] (NCBI Entrez Gene Database, 7490)
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Genes

94 genes co-occuring with the biological term wt1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADGRE5 adhesion G protein-coupled receptor E5
AMER1 APC membrane recruitment protein 1
AR androgen receptor
ATP10A ATPase, class V, type 10A
BAALC brain and acute leukemia, cytoplasmic
BASP1 brain abundant, membrane attached signal protein 1
BCL2 B-cell CLL/lymphoma 2
BIRC5 baculoviral IAP repeat containing 5
BRCA2 breast cancer 2, early onset
CCND1 cyclin D1
CCNE1 cyclin E1
CDC73 cell division cycle 73
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH13 cadherin 13
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTCF CCCTC-binding factor (zinc finger protein)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DMP1 dentin matrix acidic phosphoprotein 1
DMTF1 cyclin D binding myb-like transcription factor 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EPOR erythropoietin receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
F13A1 coagulation factor XIII, A1 polypeptide
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FLT3 fms-related tyrosine kinase 3
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA2 GATA binding protein 2
GOLM1 golgi membrane protein 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HOXA10 homeobox A10
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HTRA2 HtrA serine peptidase 2
IFI16 interferon, gamma-inducible protein 16
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
KIRREL2 kin of IRRE like 2 (Drosophila)
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRAS Kirsten rat sarcoma viral oncogene homolog
LIMS1 LIM and senescent cell antigen-like domains 1
MIR15A microRNA 15a
MIR16-1 microRNA 16-1
MSH6 mutS homolog 6
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NDRG2 NDRG family member 2
NES nestin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NR0B1 nuclear receptor subfamily 0, group B, member 1
NUP210 nucleoporin 210kDa
NUP98 nucleoporin 98kDa
PAWR PRKC, apoptosis, WT1, regulator
PAX3 paired box 3
PAX5 paired box 5
PAX6 paired box 6
PAX8 paired box 8
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPN podoplanin
PODXL podocalyxin-like
PRAME preferentially expressed antigen in melanoma
PRKCA protein kinase C, alpha
PRTN3 proteinase 3
PTEN phosphatase and tensin homolog
RB1 retinoblastoma 1
RBM4 RNA binding motif protein 4
ROR1 receptor tyrosine kinase-like orphan receptor 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SRPK1 SRSF protein kinase 1
SRY sex determining region Y
TBXA2R thromboxane A2 receptor
TERT telomerase reverse transcriptase
TP53 tumor protein p53
TP63 tumor protein p63
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
WT1 Wilms tumor 1
WT1-AS WT1 antisense RNA
WT2 Wilms tumor 2
ZNF224 zinc finger protein 224