x-linked hypophosphatemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A metal metabolism disorder that results from the inactivation of hormone-like substances (phosphatonins) that promote phosphate excretion which has_material_basis_in a X-linked mutation in the PHEX gene. (Human Disease Ontology, DOID_0050445)
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Genes

105 genes co-occuring with the disease x-linked hypophosphatemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PHEX phosphate regulating endopeptidase homolog, X-linked 3.35258
FGF23 fibroblast growth factor 23 2.91559
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 2.42892
MEPE matrix extracellular phosphoglycoprotein 2.29566
PTH parathyroid hormone 1.87515
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.84454
EMP1 epithelial membrane protein 1 1.75732
DMP1 dentin matrix acidic phosphoprotein 1 1.74415
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 1.69133
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1.657
FAM20C family with sequence similarity 20, member C 1.5818
KL klotho 1.55734
ALPPL2 alkaline phosphatase, placental-like 2 1.30925
ALPP alkaline phosphatase, placental 1.30838
ALPL alkaline phosphatase, liver/bone/kidney 1.30794
CLCN5 chloride channel, voltage-sensitive 5 1.29483
FGF1 fibroblast growth factor 1 (acidic) 1.22042
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 1.18971
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 1.18927
SKA1 spindle and kinetochore associated complex subunit 1 1.16221
SFRP4 secreted frizzled-related protein 4 1.04882
MME membrane metallo-endopeptidase 0.95996
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.958287
MED4 mediator complex subunit 4 0.953273
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.931242
IBSP integrin-binding sialoprotein 0.912257
MED1 mediator complex subunit 1 0.909787
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 0.902799
BGLAP bone gamma-carboxyglutamate (gla) protein 0.878195
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.861818
FRZB frizzled-related protein 0.848307
GLRA2 glycine receptor, alpha 2 0.833558
DSPP dentin sialophosphoprotein 0.813052
SOST sclerostin 0.781888
FAM20B family with sequence similarity 20, member B 0.777795
CHPF chondroitin polymerizing factor 0.746391
FGF6 fibroblast growth factor 6 0.740299
IP6K1 inositol hexakisphosphate kinase 1 0.716828
SFRP1 secreted frizzled-related protein 1 0.703938
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.697109
SMS spermine synthase 0.690694
FURIN furin (paired basic amino acid cleaving enzyme) 0.681495
AMTN amelotin 0.680697
LUZP6 leucine zipper protein 6 0.65565
CFAP20 cilia and flagella associated protein 20 0.654858
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.643009
IP6K2 inositol hexakisphosphate kinase 2 0.604981
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 0.557509
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.55518
SPP1 secreted phosphoprotein 1 0.552463
MID1 midline 1 0.550911
FGF7 fibroblast growth factor 7 0.541217
PHKG2 phosphorylase kinase, gamma 2 (testis) 0.529994
INHBB inhibin, beta B 0.501144
ORAOV1 oral cancer overexpressed 1 0.500761
FAM20A family with sequence similarity 20, member A 0.497703
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.485885
FGF14 fibroblast growth factor 14 0.472225
CALCA calcitonin-related polypeptide alpha 0.458619
STC1 stanniocalcin 1 0.445052
KLB klotho beta 0.42589
KLRC3 killer cell lectin-like receptor subfamily C, member 3 0.42214
EDARADD EDAR-associated death domain 0.421765
STC2 stanniocalcin 2 0.403064
OCRL oculocerebrorenal syndrome of Lowe 0.402692
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 0.366671
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.361502
PEX2 peroxisomal biogenesis factor 2 0.360026
ECE2 endothelin converting enzyme 2 0.348246
FGFR3 fibroblast growth factor receptor 3 0.345308
TIGAR TP53 induced glycolysis regulatory phosphatase 0.342739
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.336144
FGF8 fibroblast growth factor 8 (androgen-induced) 0.331025
IGF1 insulin-like growth factor 1 (somatomedin C) 0.318635
FGF20 fibroblast growth factor 20 0.304503
AMBN ameloblastin (enamel matrix protein) 0.304142
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 0.301254
RNASEH2A ribonuclease H2, subunit A 0.277227
GCM2 glial cells missing homolog 2 (Drosophila) 0.270819
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.266558
FGF19 fibroblast growth factor 19 0.262306
GNAS GNAS complex locus 0.257711
EGR1 early growth response 1 0.247852
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 0.242945
GTF2B general transcription factor IIB 0.238054
S100G S100 calcium binding protein G 0.236312
CLCA4 chloride channel accessory 4 0.233878
CKAP2 cytoskeleton associated protein 2 0.232142
SIX6 SIX homeobox 6 0.228333
COL1A2 collagen, type I, alpha 2 0.220766
MYO5A myosin VA (heavy chain 12, myoxin) 0.220424
BMP1 bone morphogenetic protein 1 0.208245
ASL argininosuccinate lyase 0.198709
TRPV5 transient receptor potential cation channel, subfamily V, member 5 0.19742
CLCA2 chloride channel accessory 2 0.196779
TMPO thymopoietin 0.19582
COL10A1 collagen, type X, alpha 1 0.185313
CASR calcium-sensing receptor 0.173571
FGF9 fibroblast growth factor 9 0.171785
FRS2 fibroblast growth factor receptor substrate 2 0.171036
DDIT4 DNA-damage-inducible transcript 4 0.170299
SEPT4 septin 4 0.165435
SAT1 spermidine/spermine N1-acetyltransferase 1 0.164359
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.164149
FGF3 fibroblast growth factor 3 0.162109